Dupilumab significantly improves sleep outcomes in adult patients with atopic dermatitis: results from five randomized clinical trials

Sleep disturbances are part of a symptom triad, along with itch and pain, that patients with atopic dermatitis (AD) report as being frequent and burdensome.1 The effects of dupilumab on sleep were evaluated in adults with chronic AD in 5 randomized, double-blind, placebo-controlled clinical trials (N=2632). The phase 2b (NCT01859988)2 and the two phase 3 SOLO trials (SOLO 1, NCT02277743; SOLO 2, NCT02277769)3 were 16-week studies of dupilumab monotherapy, the 16-week CAFÉ (NCT02755649)4 and the 52-week CHRONOS trials (NCT02260986)5 evaluated dupilumab with concomitant topical corticosteroids (TCS).

[1]  J. Silverberg,et al.  Validation of four single-item patient-reported assessments of sleep in adult atopic dermatitis patients: Sleep in atopic dermatitis. , 2019, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[2]  G. Yancopoulos,et al.  Long-term management of moderate-to-severe atopic dermatitis with dupilumab and concomitant topical corticosteroids (LIBERTY AD CHRONOS): a 1-year, randomised, double-blinded, placebo-controlled, phase 3 trial , 2017, The Lancet.

[3]  Jonathan R. Brestoff,et al.  Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch , 2017, Cell.

[4]  J. Silverberg,et al.  Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis. , 2016, The New England journal of medicine.

[5]  G. Yosipovitch,et al.  Nocturnal Pruritus: The Battle for a Peaceful Night’s Sleep , 2016, International journal of molecular sciences.

[6]  E. R. Sutherland,et al.  Efficacy and safety of dupilumab in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical treatments: a randomised, placebo-controlled, dose-ranging phase 2b trial , 2016, The Lancet.

[7]  C. Main,et al.  Illness perception in individuals with atopic dermatitis , 2007, Psychology, health & medicine.

[8]  J. Silverberg,et al.  Dupilumab progressively improves systemic and cutaneous abnormalities in patients with atopic dermatitis , 2019, The Journal of allergy and clinical immunology.

[9]  M. Irwin,et al.  Sleep Health: Reciprocal Regulation of Sleep and Innate Immunity , 2017, Neuropsychopharmacology.