Impact of abdominal visceral and subcutaneous adipose tissue on cardiometabolic risk factors: the Jackson Heart Study.

OBJECTIVE Obesity is a major driver of cardiometabolic risk. Abdominal visceral adipose tissue (VAT) and sc adipose tissue (SAT) may confer differential metabolic risk profiles. We investigated the relations of VAT and SAT with cardiometabolic risk factors in the Jackson Heart Study cohort. METHODS Participants from the Jackson Heart Study (n=2477; 64% women; mean age, 58 yr) underwent multidetector computed tomography, and the volumetric amounts of VAT and SAT were assessed between 2007 and 2009. Cardiometabolic risk factors were examined by sex in relation to VAT and SAT. RESULTS Men had a higher mean volume of VAT (873 vs. 793 cm3) and a lower mean volume of SAT (1730 vs. 2659 cm3) than women (P=0.0001). Per 1-sd increment in either VAT or SAT, we observed elevated levels of fasting plasma glucose and triglyceride, lower levels of high-density lipoprotein-cholesterol, and increased odds ratios for hypertension, diabetes, and metabolic syndrome. The effect size of VAT in women was larger than that of SAT [fasting plasma glucose, 5.51±1.0 vs. 3.36±0.9; triglyceride, 0.17±0.01 vs. 0.05±0.01; high-density lipoprotein-cholesterol, -5.36±0.4 vs. -2.85±0.4; and odds ratio for hypertension, 1.62 (1.4-1.9) vs. 1.40 (1.2-1.6); diabetes, 1.82 (1.6-2.1) vs. 1.58 (1.4-1.8); and metabolic syndrome, 3.34 (2.8-4.0) vs. 2.06 (1.8-2.4), respectively; P<0.0001 for difference between VAT and SAT]. Similar patterns were also observed in men. Furthermore, VAT remained associated with most risk factors even after accounting for body mass index (P ranging from 0.006-0.0001). The relationship of VAT to most risk factors was significantly different between women and men. CONCLUSIONS Abdominal VAT and SAT are both associated with adverse cardiometabolic risk factors, but VAT remains more strongly associated with these risk factors. The results from this study suggest that relations with cardiometabolic risk factors are consistent with a pathogenic role of abdominal adiposity in participants of African ancestry.

[1]  R. Vasan,et al.  Abdominal Subcutaneous Adipose Tissue: A Protective Fat Depot? , 2009, Diabetes Care.

[2]  L. Balluz,et al.  Differences in prevalence of obesity among black, white, and Hispanic adults - United States, 2006-2008. , 2009, MMWR. Morbidity and mortality weekly report.

[3]  Shumei S. Sun,et al.  Visceral adiposity and its anatomical distribution as predictors of the metabolic syndrome and cardiometabolic risk factor levels. , 2008, The American journal of clinical nutrition.

[4]  A. K. Agarwal,et al.  Novel subtype of congenital generalized lipodystrophy associated with muscular weakness and cervical spine instability , 2008, American journal of medical genetics. Part A.

[5]  J. Sorkin,et al.  Sex differences in insulin action and body fat distribution in overweight and obese middle-aged and older men and women. , 2008, Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.

[6]  W. Johnson,et al.  Distinct Component Profiles and High Risk Among African Americans With Metabolic Syndrome , 2008, Diabetes Care.

[7]  Yuji Yamamoto,et al.  Beneficial effects of subcutaneous fat transplantation on metabolism. , 2008, Cell metabolism.

[8]  T. Paus,et al.  Intra-abdominal adiposity and individual components of the metabolic syndrome in adolescence: sex differences and underlying mechanisms. , 2008, Archives of pediatrics & adolescent medicine.

[9]  Xenophon Papademetris,et al.  High Visceral and Low Abdominal Subcutaneous Fat Stores in the Obese Adolescent , 2008, Diabetes.

[10]  Udo Hoffmann,et al.  Abdominal Visceral and Subcutaneous Adipose Tissue Compartments: Association With Metabolic Risk Factors in the Framingham Heart Study , 2007, Circulation.

[11]  A. Tchernof,et al.  Regional differences in adipose tissue metabolism in obese men. , 2007, Metabolism: clinical and experimental.

[12]  Tamara B Harris,et al.  Obesity, regional body fat distribution, and the metabolic syndrome in older men and women. , 2005, Archives of internal medicine.

[13]  S. Heymsfield,et al.  Comparison of visceral adipose tissue mass in adult African Americans and whites. , 2005, Obesity research.

[14]  Lynette Ekunwe,et al.  Study design for genetic analysis in the Jackson Heart Study. , 2005, Ethnicity & disease.

[15]  M. Andrew,et al.  Recruiting African-American research participation in the Jackson Heart Study: methods, response rates, and sample description. , 2005, Ethnicity & disease.

[16]  S. Kritchevsky,et al.  The association of regional fat depots with hypertension in older persons of white and African American ethnicity. , 2004, American journal of hypertension.

[17]  Claude Lenfant,et al.  Definition of Metabolic Syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association Conference on Scientific Issues Related to Definition , 2004, Arteriosclerosis, thrombosis, and vascular biology.

[18]  S. Haffner,et al.  Central adiposity determines prevalence differences of the metabolic syndrome. , 2003, Obesity research.

[19]  G. Watts,et al.  Waist circumference, waist-to-hip ratio and body mass index as predictors of adipose tissue compartments in men. , 2003, QJM : monthly journal of the Association of Physicians.

[20]  J. Janosky,et al.  Obesity, regional fat distribution, and syndrome X in obese black versus white adolescents: race differential in diabetogenic and atherogenic risk factors. , 2003, The Journal of clinical endocrinology and metabolism.

[21]  B. Penninx,et al.  Visceral adipose tissue cutoffs associated with metabolic risk factors for coronary heart disease in women. , 2003, Diabetes care.

[22]  S. Kritchevsky,et al.  Association between regional adipose tissue distribution and both type 2 diabetes and impaired glucose tolerance in elderly men and women. , 2003, Diabetes care.

[23]  Robert Ross,et al.  Body mass index, waist circumference, and health risk: evidence in support of current National Institutes of Health guidelines. , 2002, Archives of internal medicine.

[24]  R. Bergman,et al.  Influence of total vs. visceral fat on insulin action and secretion in African American and white children. , 2001, Obesity research.

[25]  A. Folsom,et al.  Associations of fat distribution and obesity with hypertension in a bi-ethnic population: the ARIC study. Atherosclerosis Risk in Communities Study. , 2000, Obesity research.

[26]  C. Bouchard,et al.  Race, visceral adipose tissue, plasma lipids, and lipoprotein lipase activity in men and women: the Health, Risk Factors, Exercise Training, and Genetics (HERITAGE) family study. , 2000, Arteriosclerosis, thrombosis, and vascular biology.

[27]  D. Matthews,et al.  Visceral adipose tissue is an independent correlate of glucose disposal in older obese postmenopausal women. , 2000, The Journal of clinical endocrinology and metabolism.

[28]  J S Yudkin,et al.  Journal of Clinical Endocrinology and Metabolism Printed in U.S.A. Copyright © 1997 by The Endocrine Society Subcutaneous Adipose Tissue Releases Interleukin-6, But Not Tumor Necrosis Factor-�, in Vivo* , 2022 .