Unraveling the therapeutic effects of mesenchymal stem cells in asthma

[1]  N. Arsenijević,et al.  Mesenchymal Stem Cell-Derived Exosomes and Other Extracellular Vesicles as New Remedies in the Therapy of Inflammatory Diseases , 2019, Cells.

[2]  R. Rahbarghazi,et al.  Toll-like receptor bioactivity in endothelial progenitor cells , 2019, Cell and Tissue Research.

[3]  P. Rocco,et al.  Multiple doses of adipose tissue‐derived mesenchymal stromal cells induce immunosuppression in experimental asthma , 2019, Stem cells translational medicine.

[4]  Mingyi Zhao,et al.  Functions of Exosomes in the Triangular Relationship between the Tumor, Inflammation, and Immunity in the Tumor Microenvironment , 2019, Journal of immunology research.

[5]  R. Perez-Fernandez,et al.  Mesenchymal Stem Cells in Homeostasis and Systemic Diseases: Hypothesis, Evidences, and Therapeutic Opportunities , 2019, International journal of molecular sciences.

[6]  E. Jassem,et al.  MicroRNAs: Potential Biomarkers and Targets of Therapy in Allergic Diseases? , 2019, Archivum Immunologiae et Therapiae Experimentalis.

[7]  N. Arsenijević,et al.  Mesenchymal Stem Cell-Based Therapy of Inflammatory Lung Diseases: Current Understanding and Future Perspectives , 2019, Stem cells international.

[8]  W. Wen,et al.  Human pluripotent stem cell‐derived mesenchymal stem cells prevent chronic allergic airway inflammation via TGF‐&bgr;1‐Smad2/Smad3 signaling pathway in mice , 2019, Molecular immunology.

[9]  Min He,et al.  Effect of mesenchymal stromal (stem) cell (MSC) transplantation in asthmatic animal models: A systematic review and meta-analysis. , 2019, Pulmonary pharmacology & therapeutics.

[10]  P. Rocco,et al.  Serum from Asthmatic Mice Potentiates the Therapeutic Effects of Mesenchymal Stromal Cells in Experimental Allergic Asthma , 2018, Stem cells translational medicine.

[11]  Mohammad Reza Aslani,et al.  Bone marrow mesenchymal stem cells and condition media diminish inflammatory adhesion molecules of pulmonary endothelial cells in an ovalbumin-induced asthmatic rat model. , 2019, Microvascular research.

[12]  Mohammad Reza Aslani,et al.  Systemic delivery of mesenchymal stem cells condition media in repeated doses acts as magic bullets in restoring IFN‐&ggr;/IL‐4 balance in asthmatic rats , 2018, Life sciences.

[13]  H. Tse,et al.  Connexin 43-Mediated Mitochondrial Transfer of iPSC-MSCs Alleviates Asthma Inflammation , 2018, Stem cell reports.

[14]  Ranran Dai,et al.  Intratracheal administration of adipose derived mesenchymal stem cells alleviates chronic asthma in a mouse model , 2018, BMC Pulmonary Medicine.

[15]  Hong-Yu Zhang,et al.  Human iPSC-MSCs prevent steroid-resistant neutrophilic airway inflammation via modulating Th17 phenotypes , 2018, Stem cell research & therapy.

[16]  R. Rahbarghazi,et al.  Bone marrow mesenchymal stem cells modified pathological changes and immunological responses in ovalbumin-induced asthmatic rats possibly by the modulation of miRNA155 and miRNA133. , 2018, General physiology and biophysics.

[17]  N. Delirezh,et al.  The effects of bone marrow-derived mesenchymal stem cells on ovalbumin-induced allergic asthma and cytokine responses in mice , 2018, Iranian journal of basic medical sciences.

[18]  Yuesi Wang,et al.  Human placenta mesenchymal stem cells suppress airway inflammation in asthmatic rats by modulating Notch signaling. , 2018, Molecular medicine reports.

[19]  A. Agrawal,et al.  Regenerative abilities of mesenchymal stem cells through mitochondrial transfer , 2018, Journal of Biomedical Science.

[20]  H. Chen,et al.  MicroRNA-21 Mediates the Protective Effects of Mesenchymal Stem Cells Derived from iPSCs to Human Bronchial Epithelial Cell Injury Under Hypoxia , 2018, Cell transplantation.

[21]  Hong-Yu Zhang,et al.  The genes involved in asthma with the treatment of human embryonic stem cell‐derived mesenchymal stem cells , 2018, Molecular immunology.

[22]  Ying Lin,et al.  Mesenchymal stem cell exosomes promote immunosuppression of regulatory T cells in asthma , 2017, Experimental cell research.

[23]  S. Nagashima,et al.  Effects of mesenchymal stromal cells play a role the oxidant/antioxidant balance in a murine model of asthma. , 2017, Allergologia et immunopathologia.

[24]  Jee-Yin Ahn,et al.  Strategies to enhance paracrine potency of transplanted mesenchymal stem cells in intractable neonatal disorders , 2018, Pediatric Research.

[25]  Clare L. Bennett,et al.  Apoptosis in mesenchymal stromal cells induces in vivo recipient-mediated immunomodulation , 2017, Science Translational Medicine.

[26]  P. Giavina-Bianchi,et al.  Animal models of asthma: utility and limitations , 2017, Journal of asthma and allergy.

[27]  Yuesi Wang,et al.  Placenta-derived mesenchymal stem cells improve airway hyperresponsiveness and inflammation in asthmatic rats by modulating the Th17/Treg balance , 2017, Molecular medicine reports.

[28]  K. So,et al.  Oxidative Stress in Stem Cell Aging , 2017, Cell transplantation.

[29]  A. Caplan,et al.  Chronic asthma and Mesenchymal stem cells: Hyaluronan and airway remodeling , 2017, Journal of Inflammation.

[30]  R. Perez-Fernandez,et al.  Mesenchymal Stem Cell Secretome: Toward Cell-Free Therapeutic Strategies in Regenerative Medicine , 2017, International journal of molecular sciences.

[31]  Deokhoon Park,et al.  Immunologic regulatory effects of human umbilical cord blood‐derived mesenchymal stem cells in a murine ovalbumin asthma model , 2017, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[32]  H. Peh,et al.  Aeroallergens Induce Reactive Oxygen Species Production and DNA Damage and Dampen Antioxidant Responses in Bronchial Epithelial Cells , 2017, The Journal of Immunology.

[33]  M. Martins,et al.  Human adipose tissue mesenchymal stromal cells and their extracellular vesicles act differentially on lung mechanics and inflammation in experimental allergic asthma , 2017, Stem Cell Research & Therapy.

[34]  Y. Baran,et al.  Effects of Intraperitoneal Injection of Allogeneic Bone Marrow-derived Mesenchymal Stem Cells on Bronchiolitis Obliterans in Mice Model. , 2017, Iranian journal of allergy, asthma, and immunology.

[35]  B. Broughton,et al.  Intranasal administration of mesenchymoangioblast‐derived mesenchymal stem cells abrogates airway fibrosis and airway hyperresponsiveness associated with chronic allergic airways disease , 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[36]  B. Diaz,et al.  Bone Marrow, Adipose, and Lung Tissue‐Derived Murine Mesenchymal Stromal Cells Release Different Mediators and Differentially Affect Airway and Lung Parenchyma in Experimental Asthma , 2017, Stem cells translational medicine.

[37]  C. Wagner,et al.  Airway remodeling in asthma: what really matters , 2017, Cell and Tissue Research.

[38]  Mohammad Reza Aslani,et al.  Bone marrow mesenchymal stem cells and their conditioned media could potentially ameliorate ovalbumin-induced asthmatic changes. , 2017, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[39]  J. Kessler,et al.  Microenvironmental factors that regulate mesenchymal stem cells: lessons learned from the study of heterotopic ossification. , 2017, Histology and histopathology.

[40]  H. Chen,et al.  microRNA-21 Mediates the Protective Effects of Mesenchymal Stem Cells Derived from iPSCs to Human Bronchial Epithelial Cell Injury Under Hypoxia. , 2017, Cell transplantation.

[41]  D. Prockop,et al.  The exciting prospects of new therapies with mesenchymal stromal cells. , 2017, Cytotherapy.

[42]  A. De Angelis,et al.  New Role of Adult Lung c-kit+ Cells in a Mouse Model of Airway Hyperresponsiveness , 2016, Mediators of inflammation.

[43]  Chee-hoon Chang,et al.  Intravenous adipose-derived mesenchymal stem cell therapy for the treatment of feline asthma: a pilot study , 2016, Journal of feline medicine and surgery.

[44]  Mohammad Reza Aslani,et al.  Contributory Anti-Inflammatory Effects of Mesenchymal Stem Cells, Not Conditioned Media, On Ovalbumin-Induced Asthmatic Changes in Male Rats , 2016, Inflammation.

[45]  A. De Angelis,et al.  Intratracheal Administration of Mesenchymal Stem Cells Modulates Tachykinin System, Suppresses Airway Remodeling and Reduces Airway Hyperresponsiveness in an Animal Model , 2016, PloS one.

[46]  C. Sagan,et al.  Mesenchymal Stem Cells Induce Suppressive Macrophages Through Phagocytosis in a Mouse Model of Asthma , 2016, Stem cells.

[47]  M. Boskabady,et al.  Evaluation of Simvastatin and Bone Marrow-Derived Mesenchymal Stem Cell Combination Therapy on Airway Remodeling in a Mouse Asthma Model , 2016, Lung.

[48]  Jian-bo Shi,et al.  MicroRNAs Involved in Asthma After Mesenchymal Stem Cells Treatment , 2016, Stem cells and development.

[49]  M. Post,et al.  Endogenous and Exogenous Stem/Progenitor Cells in the Lung and Their Role in the Pathogenesis and Treatment of Pediatric Lung Disease , 2016, Front. Pediatr..

[50]  Zichao Zhou,et al.  Mesenchymal Stem Cells Alleviate LPS-Induced Acute Lung Injury in Mice by MiR-142a-5p-Controlled Pulmonary Endothelial Cell Autophagy , 2016, Cellular Physiology and Biochemistry.

[51]  Y. Baran,et al.  Intraperitoneal mesenchymal stem cell administration ameliorates allergic rhinitis in the murine model , 2016, European Archives of Oto-Rhino-Laryngology.

[52]  K. Le Blanc,et al.  Mesenchymal stromal cells and the innate immune response. , 2015, Immunology letters.

[53]  S. Royce,et al.  Mesenchymal stem cells and serelaxin synergistically abrogate established airway fibrosis in an experimental model of chronic allergic airways disease. , 2015, Stem cell research.

[54]  D. McKenna,et al.  Systemic Administration of Human Bone Marrow‐Derived Mesenchymal Stromal Cell Extracellular Vesicles Ameliorates Aspergillus Hyphal Extract‐Induced Allergic Airway Inflammation in Immunocompetent Mice , 2015, Stem cells translational medicine.

[55]  Qi Hao,et al.  Therapeutic Effects of Human Mesenchymal Stem Cell-derived Microvesicles in Severe Pneumonia in Mice. , 2015, American journal of respiratory and critical care medicine.

[56]  Jun She,et al.  Bone marrow-derived mesenchymal stem cells enhance autophagy via PI3K/AKT signalling to reduce the severity of ischaemia/reperfusion-induced lung injury , 2015, Journal of cellular and molecular medicine.

[57]  M. Stojkovic,et al.  Mesenchymal Stem Cells: A Friend or Foe in Immune-Mediated Diseases , 2015, Stem Cell Reviews and Reports.

[58]  J. Hare,et al.  Bone Marrow-Derived c-kit+ Cells Attenuate Neonatal Hyperoxia-Induced Lung Injury , 2015, Cell transplantation.

[59]  Chee-hoon Chang,et al.  Long‐term evaluation of mesenchymal stem cell therapy in a feline model of chronic allergic asthma , 2014, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[60]  B. Thébaud,et al.  Stem cells in animal asthma models: a systematic review. , 2014, Cytotherapy.

[61]  H. Tse,et al.  Paracrine Mechanisms of Mesenchymal Stem Cell-Based Therapy: Current Status and Perspectives , 2014, Cell transplantation.

[62]  H. Tse,et al.  Mitochondrial transfer of induced pluripotent stem cell-derived mesenchymal stem cells to airway epithelial cells attenuates cigarette smoke-induced damage. , 2014, American journal of respiratory cell and molecular biology.

[63]  S. Kang,et al.  Adipose-Derived Stem Cells Ameliorate Allergic Airway Inflammation by Inducing Regulatory T Cells in a Mouse Model of Asthma , 2014, Mediators of inflammation.

[64]  Wei Wu,et al.  Intranasal sirna targeting c-kit reduces airway inflammation in experimental allergic asthma. , 2014, International journal of clinical and experimental pathology.

[65]  Y. Xuan,et al.  Comprehensive characterization of four different populations of human mesenchymal stem cells as regards their immune properties, proliferation and differentiation , 2014, International journal of molecular medicine.

[66]  Changhui Wang,et al.  Mesenchymal Stem Cells Alleviate Experimental Asthma by Inducing Polarization of Alveolar Macrophages , 2014, Inflammation.

[67]  S. Lim,et al.  Mesenchymal stem cells secrete immunologically active exosomes. , 2014, Stem cells and development.

[68]  H. Kubo,et al.  c-Kit immunoexpression delineates a putative endothelial progenitor cell population in developing human lungs. , 2014, American journal of physiology. Lung cellular and molecular physiology.

[69]  J. García-Castro,et al.  Mesenchymal stem cells regulate airway contractile tissue remodeling in murine experimental asthma , 2014, Allergy.

[70]  R. Loi,et al.  Mesenchymal Stromal Cells Mediate Aspergillus Hyphal Extract‐Induced Allergic Airway Inflammation by Inhibition of the Th17 Signaling Pathway , 2014, Stem cells translational medicine.

[71]  Christine M. Fillmore,et al.  Lung stem and progenitor cells in tissue homeostasis and disease. , 2014, Current topics in developmental biology.

[72]  T. Heng,et al.  Alveolar Macrophages Are Critical for the Inhibition of Allergic Asthma by Mesenchymal Stromal Cells , 2013, The Journal of Immunology.

[73]  W. Fibbe,et al.  Mesenchymal stromal cells: sensors and switchers of inflammation. , 2013, Cell stem cell.

[74]  O. Lee,et al.  Human Mesenchymal Stem Cells Suppress the Stretch–Induced Inflammatory miR-155 and Cytokines in Bronchial Epithelial Cells , 2013, PloS one.

[75]  A. Oikonomou,et al.  A prospective, non-randomized, no placebo-controlled, phase Ib clinical trial to study the safety of the adipose derived stromal cells-stromal vascular fraction in idiopathic pulmonary fibrosis , 2013, Journal of Translational Medicine.

[76]  W. Fibbe,et al.  Adipose Tissue‐Derived Multipotent Stromal Cells Have a Higher Immunomodulatory Capacity Than Their Bone Marrow‐Derived Counterparts , 2013, Stem cells translational medicine.

[77]  B. Diaz,et al.  Bone marrow mononuclear cell therapy in experimental allergic asthma: Intratracheal versus intravenous administration , 2013, Respiratory Physiology & Neurobiology.

[78]  P. Lehenkari,et al.  Cell Surface Structures Influence Lung Clearance Rate of Systemically Infused Mesenchymal Stromal Cells , 2013, Stem cells.

[79]  G. Camussi,et al.  Role of stem-cell-derived microvesicles in the paracrine action of stem cells. , 2013, Biochemical Society transactions.

[80]  M. Nireekshan Kumar,et al.  Miro 1 Knockdown in Stem Cells Inhibits Mitochondrial Donation Mediated Rescue of Bronchial Epithelial Injury , 2013 .

[81]  Zhaohua Zhang,et al.  Mesenchymal stem cell prevention of vascular remodeling in high flow-induced pulmonary hypertension through a paracrine mechanism. , 2012, International immunopharmacology.

[82]  I. Sekiya,et al.  Intra-articular injection of human mesenchymal stem cells (MSCs) promote rat meniscal regeneration by being activated to express Indian hedgehog that enhances expression of type II collagen. , 2012, Osteoarthritis and cartilage.

[83]  Tao Wang,et al.  Silencing of c-kit with small interference RNA attenuates inflammation in a murine model of allergic asthma. , 2012, International journal of molecular medicine.

[84]  D. Prockop,et al.  Medical therapies with adult stem/progenitor cells (MSCs): A backward journey from dramatic results in vivo to the cellular and molecular explanations , 2012, Journal of cellular biochemistry.

[85]  D. Rowlands,et al.  Mitochondrial transfer from bone-marrow–derived stromal cells to pulmonary alveoli protects against acute lung injury , 2012, Nature Medicine.

[86]  Y. Baran,et al.  Mesenchymal stem cells ameliorate the histopathological changes in a murine model of chronic asthma. , 2011, International immunopharmacology.

[87]  Wei Tang,et al.  Coexistence of Th1/Th2 and Th17/Treg imbalances in patients with allergic asthma. , 2011, Chinese medical journal.

[88]  N. Ziats,et al.  Bone Marrow‐Derived Mesenchymal Stromal Cells Inhibit Th2‐Mediated Allergic Airways Inflammation in Mice , 2011, Stem cells.

[89]  E. Ingenito,et al.  Lung-derived mesenchymal stromal cell post-transplantation survival, persistence, paracrine expression, and repair of elastase-injured lung. , 2011, Stem cells and development.

[90]  E. Geissler,et al.  Mesenchymal stem cells together with mycophenolate mofetil inhibit antigen presenting cell and T cell infiltration into allogeneic heart grafts. , 2011, Transplant immunology.

[91]  B. Mahon,et al.  Allogeneic mesenchymal stem cells prevent allergic airway inflammation by inducing murine regulatory T cells , 2011, Allergy.

[92]  A. Caplan,et al.  Defining human mesenchymal stem cell efficacy in vivo , 2010, Journal of Inflammation.

[93]  A. Caplan,et al.  Human mesenchymal stem cells suppress chronic airway inflammation in the murine ovalbumin asthma model. , 2010, American journal of physiology. Lung cellular and molecular physiology.

[94]  N. Gibran,et al.  Mesenchymal stem cells: paracrine signaling and differentiation during cutaneous wound repair. , 2010, Experimental cell research.

[95]  Q. Hamid,et al.  Airway remodeling in asthma. , 2010, Current opinion in pharmacology.

[96]  M. Krampera,et al.  Human bone marrow and adipose tissue mesenchymal stem cells: a user's guide. , 2010, Stem cells and development.

[97]  S. Holgate.  A Brief History of Asthma and Its Mechanisms to Modern Concepts of Disease Pathogenesis , 2010, Allergy, asthma & immunology research.

[98]  A. Keane-Myers,et al.  Bone marrow stromal cells use TGF-β to suppress allergic responses in a mouse model of ragweed-induced asthma , 2010, Proceedings of the National Academy of Sciences.

[99]  D. Shin,et al.  Adipose-derived stromal cells inhibit allergic airway inflammation in mice. , 2010, Stem cells and development.

[100]  H. Bu,et al.  Mesenchymal stem cells inhibit complement activation by secreting factor H. , 2010, Stem cells and development.

[101]  William W. Busse,et al.  Asthma: Clinical expression and molecular mechanisms , 2010, Journal of Allergy and Clinical Immunology.

[102]  S. Phipps,et al.  Antagonism of microRNA-126 suppresses the effector function of TH2 cells and the development of allergic airways disease , 2009, Proceedings of the National Academy of Sciences.

[103]  Yufang Shi,et al.  Species Variation in the Mechanisms of Mesenchymal Stem Cell‐Mediated Immunosuppression , 2009, Stem cells.

[104]  Kyuhong Lee,et al.  Study of a BALB/c Mouse Model for Allergic Asthma , 2008, Toxicological research.

[105]  E. Geissler,et al.  Mesenchymal stem cells can induce long-term acceptance of solid organ allografts in synergy with low-dose mycophenolate. , 2008, Transplant immunology.

[106]  S. Eisenbarth.  Use and limitations of alum‐based models of allergy , 2008, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[107]  C. Lemière,et al.  Diagnosis and management of work-related asthma: American College Of Chest Physicians Consensus Statement. , 2008, Chest.

[108]  Y. Kajiwara,et al.  Intravenous administration of bone marrow stromal cells increases survivin and Bcl-2 protein expression and improves sensorimotor function following ischemia in rats , 2008, Neuroscience Letters.

[109]  K. Atkinson,et al.  Therapeutic applications of mesenchymal stromal cells. , 2007, Seminars in cell & developmental biology.

[110]  Wei Zhang,et al.  Effects of human mesenchymal stem cells on the differentiation of dendritic cells from CD34+ cells. , 2007, Stem cells and development.

[111]  P. Sly,et al.  Animal models of asthma , 2007, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[112]  T. Nakamura,et al.  Autologous Transplantation of Adipose Tissue‐Derived Stromal Cells Ameliorates Pulmonary Emphysema , 2006, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[113]  C. Ober,et al.  Asthma genetics 2006: the long and winding road to gene discovery , 2006, Genes and Immunity.

[114]  P. Poole‐Wilson,et al.  The dying stem cell hypothesis: immune modulation as a novel mechanism for progenitor cell therapy in cardiac muscle. , 2005, Journal of the American College of Cardiology.

[115]  D. Prockop,et al.  Differentiation, cell fusion, and nuclear fusion during ex vivo repair of epithelium by human adult stem cells from bone marrow stroma , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[116]  Hilde van der Togt,et al.  Publisher's Note , 2003, J. Netw. Comput. Appl..

[117]  K. McDowell,et al.  Pathophysiology of asthma. , 2000, Respiratory care clinics of North America.

[118]  C. Bertrand,et al.  Interleukin-4 is required for the induction of lung Th2 mucosal immunity. , 1995, American journal of respiratory cell and molecular biology.