Comparison of Kinetics of Sevoflurane and Isoflurane in Humans

The low solubility of sevoflurane in blood suggests that this agent should enter and leave the body more rapidly than isoflurane. However, the closeness of sevoflurane and isoflurane tissue/blood partition coefficients suggests that the rates of equilibration with and elimination from tissues should

[1]  E. Eger,et al.  Does the duration of anesthetic administration affect the pharmacokinetics or metabolism of inhaled anesthetics in humans? , 1987, Anesthesia and analgesia.

[2]  E. Eger,et al.  Rates of Awakening from Anesthesia with I‐653, Halothane, Isoflurane, and Sevoflurane: A Test of the Effect of Anesthetic Concentration and Duration in Rats , 1987, Anesthesia and analgesia.

[3]  Lcdr L. Sheffer,et al.  Nitrous‐oxide‐induced Diffusion Hypoxia in Patients Breathing Spontaneously , 1972, Anesthesiology.

[4]  E. Eger,et al.  ANAESTHETIC SOLUBILITY IN BLOOD AND TISSUES: VALUES AND SIGNIFICANCE. , 1964, British journal of anaesthesia.

[5]  Stanton A. Glantz,et al.  Primer of biostatistics : statistical software program version 6.0 , 1981 .

[6]  R. Weiskopf,et al.  Pharmacokinetics of Desflurane, Sevoflurane, Isoflurane, and Halothane in Pigs , 1990, Anesthesia and analgesia.

[7]  E. Eger,et al.  Alveolar-to-arterial-to-venous anesthetic partial pressure differences in humans. , 1986, Anesthesiology.

[8]  E. Eger,et al.  Delayed Approach of Arterial to Alveolar Nitrous Oxide Partial Pressures in Dog and in Man , 1966, Anesthesiology.

[9]  R. Siebeck.  Über die Aufnahme von Stickoxydul im Blut , 1909 .

[10]  W. Mapleson,et al.  Solubility coefficients for inhaled anaesthetics for water, oil and biological media. , 1973, British journal of anaesthesia.

[11]  E. Eger,et al.  Anesthetic uptake and action , 1974 .

[12]  J. Durnin,et al.  The assessment of the amount of fat in the human body from measurements of skinfold thickness , 1967, British Journal of Nutrition.

[13]  N. Assali,et al.  Nitrous Oxide Solubility in Fetal and Uterine Tissues in Human Pregnancy∗ , 1959, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[14]  D. Holaday,et al.  Clinical Characteristics and Biotransformation of Sevoflurane in Healthy Human Volunteers , 1981, Anesthesiology.

[15]  L. Greene,et al.  Uptake and Excretion of Subanesthetic Concentrations of Nitrous Oxide in Man , 1962, Anesthesiology.