论文信息 - LEGO-like DNA Structures

LEGO-like DNA Structures

DNA “bricks” consisting of short sequences of single-stranded DNA self-assemble into a wide variety of shapes. Parallels are often drawn between the construction of molecular structures and building toy models in LEGO bricks. This analogy is particularly suitable for the method reported by Ke et al. on page 1177 of this issue (1). The authors describe the construction of arbitrary and discrete three-dimensional (3D) DNA structures by self-assembly of single-stranded DNA “bricks.” The method opens a new route to complex self-assembled (3D) nanostructures that may serve as addressable templates for placing guest molecules with high precision, with possible applications in biophysics, medicine, and nanoelectronics.

Kurt V. Gothelf

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