The Netrin family of guidance factors: emphasis on Netrin-1 signalling

[1]  G. Gundersen Microtubule Capture: IQGAP and CLIP-170 Expand the Repertoire , 2002, Current Biology.

[2]  D. Bentley,et al.  Accumulation of actin in subsets of pioneer growth cone filopodia in response to neural and epithelial guidance cues in situ , 1993, The Journal of cell biology.

[3]  Timothy E. Kennedy,et al.  Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord , 1994, Cell.

[4]  M. Bastiani,et al.  Guidance of neuronal growth cones: selective fasciculation in the grasshopper embryo. , 1983, Cold Spring Harbor symposia on quantitative biology.

[5]  V. Gagliardini,et al.  Semaphorin III Can Induce Death in Sensory Neurons , 1999, Molecular and Cellular Neuroscience.

[6]  Z. Kaprielian,et al.  The molecular basis of retinotectal topography , 1994, BioEssays : news and reviews in molecular, cellular and developmental biology.

[7]  H. Cooper,et al.  Netrin-3 protein is localized to the axons of motor, sensory, and sympathetic neurons , 2001, Mechanisms of Development.

[8]  T. Pawson,et al.  Multiple ephrins control cell organization in C. elegans using kinase-dependent and -independent functions of the VAB-1 Eph receptor. , 1999, Molecular cell.

[9]  P. Forscher,et al.  Cytoskeletal remodeling during growth cone-target interactions , 1993, The Journal of cell biology.

[10]  Veeranna,et al.  Phosphorylation of MEK1 by cdk5/p35 Down-regulates the Mitogen-activated Protein Kinase Pathway* , 2002, The Journal of Biological Chemistry.

[11]  Y. Rao,et al.  Molecular control of neuronal migration. , 2002, BioEssays : news and reviews in molecular, cellular and developmental biology.

[12]  I Biaggioni,et al.  Adenosine A2B receptors. , 1997, Pharmacological reviews.

[13]  M. Tessier-Lavigne,et al.  Function of an axonal chemoattractant modulated by metalloprotease activity. , 2000, Science.

[14]  D. Brown,et al.  The tyrosine kinase connection: how GPI-anchored proteins activate T cells. , 1993, Current opinion in immunology.

[15]  R. Yuste,et al.  Aberrant development of hippocampal circuits and altered neural activity in netrin 1-deficient mice. , 2000, Development.

[16]  A. B. Huber,et al.  Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance. , 2003, Annual review of neuroscience.

[17]  John G Flanagan,et al.  Topographically Specific Effects of ELF-1 on Retinal Axon Guidance In Vitro and Retinal Axon Mapping In Vivo , 1996, Cell.

[18]  Lindsay Hinck,et al.  Netrin-1/neogenin interaction stabilizes multipotent progenitor cap cells during mammary gland morphogenesis. , 2003, Developmental cell.

[19]  C. Métin,et al.  A role for netrin-1 in the guidance of cortical efferents. , 1997, Development.

[20]  G. Ming,et al.  A CaMKII/Calcineurin Switch Controls the Direction of Ca2+-Dependent Growth Cone Guidance , 2004, Neuron.

[21]  F. Bonhoeffer,et al.  In vitro experiments on axon guidance demonstrating an anterior‐posterior gradient on the tectum. , 1982, The EMBO journal.

[22]  A. Chédotal,et al.  Directional Guidance of Oligodendroglial Migration by Class 3 Semaphorins and Netrin-1 , 2002, The Journal of Neuroscience.

[23]  M. Kirschner,et al.  Microtubule behavior in the growth cones of living neurons during axon elongation , 1991, The Journal of cell biology.

[24]  J. Culotti,et al.  UNC-5, a transmembrane protein with immunoglobulin and thrombospondin type 1 domains, guides cell and pioneer axon migrations in C. elegans , 1992, Cell.

[25]  J. Tschopp,et al.  The death domain motif found in Fas (Apo‐1) and TNF receptor is present in proteins involved in apoptosis and axonal guidance , 1995, FEBS letters.

[26]  J. Culotti,et al.  UNC-40, a C. elegans Homolog of DCC (Deleted in Colorectal Cancer), Is Required in Motile Cells Responding to UNC-6 Netrin Cues , 1996, Cell.

[27]  D. Moscatelli,et al.  The FGF family of growth factors and oncogenes. , 1992, Advances in cancer research.

[28]  D. V. Vactor Adhesion and signaling in axonal fasciculation , 1998, Current Opinion in Neurobiology.

[29]  Michael Piper,et al.  Movement through slits: Cellular migration via the Slit family , 2003, BioEssays : news and reviews in molecular, cellular and developmental biology.

[30]  A. Wilks,et al.  The expression patterns of guidance receptors, DCC and Neogenin, are spatially and temporally distinct throughout mouse embryogenesis. , 1997, Developmental biology.

[31]  C. Goodman,et al.  Genetic Analysis of the Mechanisms Controlling Target Selection: Complementary and Combinatorial Functions of Netrins, Semaphorins, and IgCAMs , 1998, Cell.

[32]  Michael S. Deiner,et al.  Altered Midline Axon Pathways and Ectopic Neurons in the Developing Hypothalamus of Netrin-1- and DCC-Deficient Mice , 1999, The Journal of Neuroscience.

[33]  B. Hogan,et al.  Novel Role for Netrins in Regulating Epithelial Behavior during Lung Branching Morphogenesis , 2004, Current Biology.

[34]  S. R. Y. Cajal La rétine des vertébrés , 1892 .

[35]  E. Hedgecock,et al.  Neuroglia and Pioneer Neurons Express UNC-6 to Provide Global and Local Netrin Cues for Guiding Migrations in C. elegans , 1996, Neuron.

[36]  I. Fischer,et al.  MAP1B expression and microtubule stability in growing and regenerating axons , 2000, Microscopy research and technique.

[37]  J. Hsieh,et al.  Induction of apoptosis and G2/M cell cycle arrest by DCC , 1999, Oncogene.

[38]  J. Bolz,et al.  Semaphorin 3A–Vascular Endothelial Growth Factor-165 Balance Mediates Migration and Apoptosis of Neural Progenitor Cells by the Recruitment of Shared Receptor , 2001, The Journal of Neuroscience.

[39]  J. Culotti,et al.  UNC-6, a laminin-related protein, guides cell and pioneer axon migrations in C. elegans , 1992, Neuron.

[40]  H. Keshishian,et al.  Neuronal pathfinding and recognition: roles of cell adhesion molecules. , 1996, Developmental biology.

[41]  Mu-ming Poo,et al.  Turning of Retinal Growth Cones in a Netrin-1 Gradient Mediated by the Netrin Receptor DCC , 1997, Neuron.

[42]  M. Condic,et al.  Characterization of Netrin-1, Neogenin and cUNC-5H3 expression during chick dorsal root ganglia development. , 2003, Gene expression patterns : GEP.

[43]  J. Sanes,et al.  Identification and expression of mouse netrin-4 , 2000, Mechanisms of Development.

[44]  M. Poo,et al.  Binding of DCC by Netrin-1 to Mediate Axon Guidance Independent of Adenosine A2B Receptor Activation , 2001, Science.

[45]  C. Goodman,et al.  Slit Is the Midline Repellent for the Robo Receptor in Drosophila , 1999, Cell.

[46]  C. Goodman,et al.  Genes that control neuromuscular specificity in Drosophila , 1993, Cell.

[47]  A. Sweatt,et al.  Microtubule-associated protein 1 subunit expression in primary cultures of rat brain , 2000, Brain Research Bulletin.

[48]  W. Dreyer,et al.  Neogenin, an avian cell surface protein expressed during terminal neuronal differentiation, is closely related to the human tumor suppressor molecule deleted in colorectal cancer , 1994, The Journal of cell biology.

[49]  D. Gilbert,et al.  Netrin-3, a Mouse Homolog of Human NTN2L, Is Highly Expressed in Sensory Ganglia and Shows Differential Binding to Netrin Receptors , 1999, The Journal of Neuroscience.

[50]  L. Astic,et al.  Expression of netrin-1 and netrin-1 receptor, DCC, in the rat olfactory nerve pathway during development and axonal regeneration , 2002, Neuroscience.

[51]  P. Devreotes,et al.  Chemotaxis in eukaryotic cells: a focus on leukocytes and Dictyostelium. , 1988, Annual review of cell biology.

[52]  C. Holt,et al.  Navigational errors made by growth cones without filopodia in the embryonic xenopus brain , 1993, Neuron.

[53]  P. Maness,et al.  A MAP Kinase-Signaling Pathway Mediates Neurite Outgrowth on L1 and Requires Src-Dependent Endocytosis , 2000, The Journal of Neuroscience.

[54]  Hao Wang,et al.  Netrin-1 Is Required for Commissural Axon Guidance in the Developing Vertebrate Nervous System , 1996, Cell.

[55]  Kathleen R. Cho,et al.  The DCC gene product in cellular differentiation and colorectal tumorigenesis. , 1994, Genes & development.

[56]  A. Schuldt Developmental biology: Guidance molecule goes global , 2003, Nature.

[57]  J. Rhim,et al.  Activation of EphA receptor tyrosine kinase inhibits the Ras/MAPK pathway , 2001, Nature Cell Biology.

[58]  M. Hatten Central nervous system neuronal migration. , 1999, Annual review of neuroscience.

[59]  D. V. Vactor,et al.  From the growth cone surface to the cytoskeleton: one journey, many paths. , 2000, Journal of neurobiology.

[60]  R. Stancou,et al.  Protein kinase A phosphorylation of RhoA mediates the morphological and functional effects of cyclic AMP in cytotoxic lymphocytes. , 1996, The EMBO journal.

[61]  A. Chédotal,et al.  Netrin-1-mediated axon outgrowth and cAMP production requires interaction with adenosine A2b receptor , 2000, Nature.

[62]  T. Kennedy,et al.  Widespread Expression of Netrin-1 by Neurons and Oligodendrocytes in the Adult Mammalian Spinal Cord , 2001, The Journal of Neuroscience.

[63]  A. Kolodkin,et al.  Functions of netrins and semaphorins in axon guidance , 1996, Current Opinion in Neurobiology.

[64]  T. Kennedy,et al.  The Adaptor Protein Nck-1 Couples the Netrin-1 Receptor DCC (Deleted in Colorectal Cancer) to the Activation of the Small GTPase Rac1 through an Atypical Mechanism* , 2002, The Journal of Biological Chemistry.

[65]  J. Sanes,et al.  Lamina-specific cues guide outgrowth and arborization of retinal axons in the optic tectum. , 1995, Development.

[66]  T. Pawson,et al.  Netrin Stimulates Tyrosine Phosphorylation of the UNC-5 Family of Netrin Receptors and Induces Shp2 Binding to the RCM Cytodomain* , 2001, The Journal of Biological Chemistry.

[67]  L. Krushel,et al.  Cellular signaling by neural cell adhesion molecules of the immunoglobulin superfamily , 2000, Developmental dynamics : an official publication of the American Association of Anatomists.

[68]  S. Shimeld An amphioxus netrin gene is expressed in midline structures during embryonic and larval development , 2000, Development Genes and Evolution.

[69]  A. Hall,et al.  Rho GTPases and the actin cytoskeleton. , 1998, Science.

[70]  K. Klinger,et al.  The NTN2L gene encoding a novel human netrin maps to the autosomal dominant polycystic kidney disease region on chromosome 16p13.3. , 1997, Genomics.

[71]  C. Holt,et al.  Apoptotic Pathway and MAPKs Differentially Regulate Chemotropic Responses of Retinal Growth Cones , 2003, Neuron.

[72]  J. Juang,et al.  enabled, a dosage-sensitive suppressor of mutations in the Drosophila Abl tyrosine kinase, encodes an Abl substrate with SH3 domain-binding properties. , 1995, Genes & development.

[73]  F. Llambi,et al.  Netrin‐1 acts as a survival factor via its receptors UNC5H and DCC , 2001, The EMBO journal.

[74]  M. Tessier-Lavigne,et al.  Hierarchical Organization of Guidance Receptors: Silencing of Netrin Attraction by Slit Through a Robo/DCC Receptor Complex , 2001, Science.

[75]  S. Cohen-Cory The double life of netrin , 2002, Nature Neuroscience.

[76]  Li-Huei Tsai,et al.  A decade of CDK5 , 2001, Nature Reviews Molecular Cell Biology.

[77]  M. Tessier-Lavigne,et al.  Coordinated functions of Netrin-1 and Class 3 secreted Semaphorins in the guidance of reciprocal septohippocampal connections , 2004, Molecular and Cellular Neuroscience.

[78]  A. Horwitz,et al.  Deleted in Colorectal Carcinoma and Differentially Expressed Integrins Mediate the Directional Migration of Neural Precursors in the Rostral Migratory Stream , 2002, The Journal of Neuroscience.

[79]  M. Tessier-Lavigne,et al.  Recognition of the Neural Chemoattractant Netrin-1 by Integrins α6β4 and α3β1 Regulates Epithelial Cell Adhesion and Migration , 2003 .

[80]  T. Kennedy Cellular mechanisms of netrin function: long-range and short-range actions. , 2000, Biochemistry and cell biology = Biochimie et biologie cellulaire.

[81]  Jennifer L. Doyle,et al.  Genetic Analysis of Netrin Genes in Drosophila: Netrins Guide CNS Commissural Axons and Peripheral Motor Axons , 1996, Neuron.

[82]  J. Ávila,et al.  MAP1B Is Required for Netrin 1 Signaling in Neuronal Migration and Axonal Guidance , 2004, Current Biology.

[83]  C. Bate Pioneer neurones in an insect embryo , 1976, Nature.

[84]  P. Aspenström Effectors for the Rho GTPases. , 1999, Current opinion in cell biology.

[85]  M. Tessier-Lavigne,et al.  The axonal chemoattractant netrin-1 is also a chemorepellent for trochlear motor axons , 1995, Cell.

[86]  Y. Jan,et al.  frazzled Encodes a Drosophila Member of the DCC Immunoglobulin Subfamily and Is Required for CNS and Motor Axon Guidance , 1996, Cell.

[87]  M. Bate,et al.  Presynaptic Development at the Drosophila Neuromuscular Junction: Assembly and Localization of Presynaptic Active Zones , 1996, Neuron.

[88]  C. Waterman-Storer,et al.  Cell motility: can Rho GTPases and microtubules point the way? , 2001, Journal of cell science.

[89]  Yukitaka Ushio,et al.  A Role of Netrin-1 in the Formation of the Subcortical Structure Striatum: Repulsive Action on the Migration of Late-Born Striatal Neurons , 2001, The Journal of Neuroscience.

[90]  Mu-ming Poo,et al.  A Ligand-Gated Association between Cytoplasmic Domains of UNC5 and DCC Family Receptors Converts Netrin-Induced Growth Cone Attraction to Repulsion , 1999, Cell.

[91]  C. Holt,et al.  FGF signaling and target recognition in the developing xenopus visual system , 1995, Neuron.

[92]  L. Luo RHO GTPASES in neuronal morphogenesis , 2000, Nature Reviews Neuroscience.

[93]  M. Hanson,et al.  Hepatocyte Growth Factor/Scatter Factor Is an Axonal Chemoattractant and a Neurotrophic Factor for Spinal Motor Neurons , 1996, Neuron.

[94]  James Q. Zheng,et al.  Growth Cone Turning Induced by Direct Local Modification of Microtubule Dynamics , 2002, The Journal of Neuroscience.

[95]  Marc Tessier-Lavigne,et al.  Target attraction: Are developing axons guided by chemotropism? , 1991, Trends in Neurosciences.

[96]  S. Diriong,et al.  The two guanine nucleotide exchange factor domains of Trio link the Rac1 and the RhoA pathways in vivo , 1998, Oncogene.

[97]  B. Mueller,et al.  Growth cone guidance: first steps towards a deeper understanding. , 1999, Annual review of neuroscience.

[98]  A. Püschel Divergent properties of mouse netrins , 1999, Mechanisms of Development.

[99]  K. Komatsuzaki,et al.  Modulation of Giα2 signaling by the axonal guidance molecule UNC5H2 , 2002 .

[100]  M. Kirschner,et al.  The role of microtubule dynamics in growth cone motility and axonal growth , 1995, The Journal of cell biology.

[101]  J. Dodd,et al.  Axon guidance: A compelling case for repelling growth cones , 1995, Cell.

[102]  J. Verhaagen,et al.  Ectopic adenoviral vector-directed expression of Sema3A in organotypic spinal cord explants inhibits growth of primary sensory afferents. , 2000, Developmental biology.

[103]  J. Culotti,et al.  DCC and netrins. , 1998, Current opinion in cell biology.

[104]  Mu-ming Poo,et al.  Adaptation in the chemotactic guidance of nerve growth cones , 2002, Nature.

[105]  N. Tamamaki,et al.  Guidance of glial precursor cell migration by secreted cues in the developing optic nerve. , 2001, Development.

[106]  James D. Lauderdale,et al.  Axon Tracts Correlate withNetrin-1aExpression in the Zebrafish Embryo , 1997, Molecular and Cellular Neuroscience.

[107]  M. Masu,et al.  Deleted in Colorectal Cancer (DCC) Encodes a Netrin Receptor , 1996, Cell.

[108]  T. Kennedy,et al.  Oligodendrocyte Precursors on the Move: Mechanisms Directing Migration , 2004, The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.

[109]  P. Forscher,et al.  Cytoskeletal reorganization underlying growth cone motility , 1994, Current Opinion in Neurobiology.

[110]  K. Aktories,et al.  Rac1 and Cdc42 but Not RhoA or Rho Kinase Activities Are Required for Neurite Outgrowth Induced by the Netrin-1 Receptor DCC (Deleted in Colorectal Cancer) in N1E-115 Neuroblastoma Cells* , 2002, The Journal of Biological Chemistry.

[111]  R. Hoffmann,et al.  Glycosaminoglycan-binding properties and secondary structure of the C-terminus of netrin-1. , 2000, Biochemical and biophysical research communications.

[112]  B. Emery,et al.  Localization of the netrin guidance receptor, DCC, in the developing peripheral and enteric nervous systems , 2001, Mechanisms of Development.

[113]  E. Fearon,et al.  DCC: linking tumour suppressor genes and altered cell surface interactions in cancer? , 1995, European journal of cancer.

[114]  J. Wehland,et al.  Mena, a Relative of VASP and Drosophila Enabled, Is Implicated in the Control of Microfilament Dynamics , 1996, Cell.

[115]  P. Forscher,et al.  Substrate-cytoskeletal coupling as a mechanism for the regulation of growth cone motility and guidance. , 2000, Journal of neurobiology.

[116]  K. Kullander,et al.  Mechanisms and functions of eph and ephrin signalling , 2002, Nature Reviews Molecular Cell Biology.

[117]  B. Pedrotti,et al.  Microtubule associated protein 1B (MAP1B) promotes efficient tubulin polymerisation in vitro , 1995, FEBS letters.

[118]  I. Rooman,et al.  Netrin-1 expression in fetal and regenerating rat pancreas and its effect on the migration of human pancreatic duct and porcine islet precursor cells , 2003, Diabetologia.

[119]  M. Tessier-Lavigne,et al.  The role of the floor plate in axon guidance. , 1995, Annual review of neuroscience.

[120]  M. Salminen,et al.  Developmentally regulated expression of Netrin‐1 and ‐3 in the embryonic mouse molar tooth germ , 2003, Developmental dynamics : an official publication of the American Association of Anatomists.

[121]  S. Tobet,et al.  Deleted in Colorectal Cancer (DCC) Regulates the Migration of Luteinizing Hormone-Releasing Hormone Neurons to the Basal Forebrain , 2001, The Journal of Neuroscience.

[122]  O. Cussenot,et al.  Quantification of expression of netrins, slits and their receptors in human prostate tumors , 2003, International journal of cancer.

[123]  F. Bonhoeffer,et al.  Recognition of cell types by axonal growth cones in vitro , 1980, Nature.

[124]  S. Zipursky,et al.  Glial Cells Mediate Target Layer Selection of Retinal Axons in the Developing Visual System of Drosophila , 2001, Neuron.

[125]  Li I. Zhang,et al.  Electrical activity and development of neural circuits , 2001, Nature Neuroscience.

[126]  Anne J. Ridley,et al.  The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors , 1992, Cell.

[127]  Cornelia I. Bargmann,et al.  Inhibition of Netrin-Mediated Axon Attraction by a Receptor Protein Tyrosine Phosphatase , 2004, Science.

[128]  G. Pollerberg,et al.  The Microtubule-Associated Protein MAP1B Is Involved in Local Stabilization of Turning Growth Cones , 2000, Molecular and Cellular Neuroscience.

[129]  C. Shatz,et al.  Developmental mechanisms that generate precise patterns of neuronal connectivity , 1993, Cell.

[130]  I. Fischer,et al.  Microtubule-associated protein 1b (MAP1b) is concentrated in the distal region of growing axons , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[131]  P. Mehlen,et al.  The dependence receptors DCC and UNC5H as a link between neuronal guidance and survival , 2003, Biology of the cell.

[132]  T. Jessell,et al.  The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6 , 1994, Cell.

[133]  T. Kennedy,et al.  Netrin-1 Is a Chemorepellent for Oligodendrocyte Precursor Cells in the Embryonic Spinal Cord , 2003, The Journal of Neuroscience.

[134]  R. Goold,et al.  Inhibition of GSK-3beta leading to the loss of phosphorylated MAP-1B is an early event in axonal remodelling induced by WNT-7a or lithium. , 1998, Journal of cell science.

[135]  Alain Chédotal,et al.  Role of Slit proteins in the vertebrate brain , 2002, Journal of Physiology-Paris.

[136]  Anne J. Ridley,et al.  The small GTP-binding protein rac regulates growth factor-induced membrane ruffling , 1992, Cell.

[137]  Michael S. Deiner,et al.  Netrin-1 and DCC Mediate Axon Guidance Locally at the Optic Disc: Loss of Function Leads to Optic Nerve Hypoplasia , 1997, Neuron.

[138]  Yusuke Nakamura,et al.  p53RDL1 regulates p53-dependent apoptosis , 2003, Nature Cell Biology.

[139]  Kristin L. Whitford,et al.  Plexin Signaling via Off-Track and Rho Family GTPases , 2001, Neuron.

[140]  M. Tessier-Lavigne,et al.  MAX-1, a Novel PH/MyTH4/FERM Domain Cytoplasmic Protein Implicated in Netrin-Mediated Axon Repulsion , 2002, Neuron.

[141]  A. Wilks,et al.  Cloning of the mouse homologue of the deleted in colorectal cancer gene (mDCC) and its expression in the developing mouse embryo. , 1995, Oncogene.

[142]  H. Herrmann,et al.  Microheterogeneity of microtubule-associated proteins, MAP-1 and MAP-2, and differential phosphorylation of individual subcomponents. , 1985, The Journal of biological chemistry.

[143]  H. Baba,et al.  Netrin‐1 is crucial for the establishment of the dorsal column‐medial lemniscal system , 2004, Journal of neurochemistry.

[144]  F. Castro Chemotropic Molecules: Guides for Axonal Pathfinding and Cell Migration During CNS Development , 2003 .

[145]  A. Gurney,et al.  The netrin-G1 ligand NGL-1 promotes the outgrowth of thalamocortical axons , 2003, Nature Neuroscience.

[146]  L. Lim,et al.  The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts , 1995, Molecular and cellular biology.

[147]  M. Masu,et al.  Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors , 1997, Nature.

[148]  C. Sotelo,et al.  Netrin 1 acts as an attractive or as a repulsive cue for distinct migrating neurons during the development of the cerebellar system. , 2000, Development.

[149]  I. Black,et al.  Regulation of topographic projection in the brain: Elf-1 in the hippocamposeptal system. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[150]  D. Hall,et al.  The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans , 1990, Neuron.

[151]  S. Skaper,et al.  Cell signalling cascades regulating neuronal growth-promoting and inhibitory cues , 2001, Progress in Neurobiology.

[152]  C. Nobes,et al.  Rho, rac and cdc42 GTPases: regulators of actin structures, cell adhesion and motility. , 1995, Biochemical Society transactions.

[153]  C. Cohan,et al.  Focal loss of actin bundles causes microtubule redistribution and growth cone turning , 2002, The Journal of cell biology.

[154]  J Schultz,et al.  SMART, a simple modular architecture research tool: identification of signaling domains. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[155]  Jonathan A Raper,et al.  Semaphorins and their receptors in vertebrates and invertebrates , 2000, Current Opinion in Neurobiology.

[156]  R. Fields,et al.  Neural cell adhesion molecules in activity-dependent development and synaptic plasticity , 1996, Trends in Neurosciences.

[157]  J. Ávila,et al.  Evidence for the role of MAP1B in axon formation. , 2001, Molecular biology of the cell.

[158]  Russell L Finley,et al.  Mediation of the DCC Apoptotic Signal by DIP13α* , 2002, The Journal of Biological Chemistry.

[159]  C. Marshall,et al.  Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells , 1994, Cell.

[160]  D. Colman,et al.  A Model for Central Synaptic Junctional Complex Formation Based on the Differential Adhesive Specificities of the Cadherins , 1996, Neuron.

[161]  G. Borisy,et al.  Specific association of an M-phase kinase with isolated mitotic spindles and identification of two of its substrates as MAP4 and MAP1B. , 1991, Cell regulation.

[162]  R. Kalb,et al.  Molecular basis of semaphorin-mediated axon guidance. , 2000, Journal of neurobiology.

[163]  A. Pini,et al.  Chemorepulsion of developing motor axons by the floor plate , 1995, Neuron.

[164]  B. Dickson,et al.  Axon Guidance: Growth Cones Make an Unexpected Turn , 2002, Current Biology.

[165]  M. Barbacid Neurotrophic Factors and Their Receptors , 1995, Bio/Technology.

[166]  G. Tear Neuronal guidance. A genetic perspective. , 1999, Trends in genetics : TIG.

[167]  H. Cooper,et al.  Mouse Neogenin, a DCC-like molecule, has four splice variants and is expressed widely in the adult mouse and during embryogenesis , 1997, Oncogene.

[168]  C. Sotelo,et al.  Floor Plate and Netrin-1 Are Involved in the Migration and Survival of Inferior Olivary Neurons , 1999, The Journal of Neuroscience.

[169]  D. Van Vactor,et al.  Axon guidance: the cytoplasmic tail. , 2002, Current opinion in cell biology.

[170]  P. Comoglio,et al.  Signalling by semaphorin receptors: cell guidance and beyond. , 2000, Trends in cell biology.

[171]  S. Kuroda,et al.  Rac1 and Cdc42 Capture Microtubules through IQGAP1 and CLIP-170 , 2002, Cell.

[172]  Robert H Miller,et al.  Glial cell migration directed by axon guidance cues , 2002, Trends in Neurosciences.

[173]  J. Meyerhardt,et al.  Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas. , 1999, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[174]  A. Hall,et al.  Rac/Cdc42 and p65PAK Regulate the Microtubule-destabilizing Protein Stathmin through Phosphorylation at Serine 16* , 2001, The Journal of Biological Chemistry.

[175]  C. Chuong,et al.  cDCC (chicken homologue to a gene deleted in colorectal carcinoma) is an epithelial adhesion molecule expressed in the basal cells and involved in epithelial-mesenchymal interaction. , 1994, Developmental biology.

[176]  M. Feller,et al.  Spontaneous Correlated Activity in Developing Neural Circuits , 1999, Neuron.

[177]  L. Landmesser,et al.  Axon guidance at choice points , 1998, Current Opinion in Neurobiology.

[178]  C. Goodman,et al.  Biochemical Purification of a Mammalian Slit Protein as a Positive Regulator of Sensory Axon Elongation and Branching , 1999, Cell.

[179]  M. Poo,et al.  The cell biology of neuronal navigation , 2001, Nature Cell Biology.

[180]  D. V. Vactor,et al.  The Microtubule Plus End Tracking Protein Orbit/MAST/CLASP Acts Downstream of the Tyrosine Kinase Abl in Mediating Axon Guidance , 2004, Neuron.

[181]  J. Sanes,et al.  Laminets: Laminin- and Netrin-Related Genes Expressed in Distinct Neuronal Subsets , 2002, Molecular and Cellular Neuroscience.

[182]  T. Kennedy,et al.  Developmental shift in expression of netrin receptors in the rat spinal cord: Predominance of UNC‐5 homologues in adulthood , 2004, Journal of neuroscience research.

[183]  V. Lemmon,et al.  Dynamic regulation of cell adhesion molecules during axon outgrowth. , 2000, Journal of neurobiology.

[184]  Seizo Yamamoto,et al.  Expression of mRNA for axon guidance molecules, such as semaphorin-III, netrins and neurotrophins, in human osteoblasts and osteoclasts , 2000, Brain Research.

[185]  Jacqueline H. Finger,et al.  The Netrin 1 Receptors Unc5h3 and Dcc Are Necessary at Multiple Choice Points for the Guidance of Corticospinal Tract Axons , 2002, The Journal of Neuroscience.

[186]  E. Frank,et al.  SEMA3A regulates developing sensory projections in the chicken spinal cord. , 2000, Journal of neurobiology.

[187]  Ken Watanabe,et al.  UNC5H1 Induces Apoptosis via Its Juxtamembrane Region through an Interaction with NRAGE* , 2003, The Journal of Biological Chemistry.

[188]  Cori Bargmann,et al.  Dynamic regulation of axon guidance , 2001, Nature Neuroscience.

[189]  B. Dickson,et al.  Short- and Long-Range Repulsion by the Drosophila Unc5 Netrin Receptor , 2001, Neuron.

[190]  Mu-ming Poo,et al.  Signal transduction underlying growth cone guidance by diffusible factors , 1999, Current Opinion in Neurobiology.

[191]  Cori Bargmann,et al.  The Netrin Receptor UNC-40/DCC Stimulates Axon Attraction and Outgrowth through Enabled and, in Parallel, Rac and UNC-115/AbLIM , 2003, Neuron.

[192]  Mu-ming Poo,et al.  Calcium signalling in the guidance of nerve growth by netrin-1 , 2000, Nature.

[193]  H. Katoh,et al.  Rho family GTPases as key regulators for neuronal network formation. , 2002, Journal of biochemistry.

[194]  P. Forscher,et al.  Growth cone advance is inversely proportional to retrograde F-actin flow , 1995, Neuron.

[195]  Kimberly M. Valentino,et al.  Expression of the Netrin‐1 receptor, deleted in colorectal cancer (DCC), is largely confined to projecting neurons in the developing forebrain , 2000, The Journal of comparative neurology.

[196]  A. Kolodkin,et al.  Silencing the Siren Guidance Cue Hierarchies at the CNS Midline , 2001, Cell.

[197]  M. Tessier-Lavigne,et al.  Netrin 1 mediates spinal cord oligodendrocyte precursor dispersal , 2003, Development.

[198]  C. Shatz,et al.  Netrin-1 Promotes Thalamic Axon Growth and Is Required for Proper Development of the Thalamocortical Projection , 2000, The Journal of Neuroscience.

[199]  S. Dedhar,et al.  NGF-Induced Axon Growth Is Mediated by Localized Inactivation of GSK-3β and Functions of the Microtubule Plus End Binding Protein APC , 2004, Neuron.

[200]  C. Sotelo,et al.  Slit antagonizes netrin-1 attractive effects during the migration of inferior olivary neurons. , 2002, Developmental biology.

[201]  L. Tsai,et al.  Cdk5 on the brain. , 2001, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[202]  David G. Wilkinson,et al.  Multiple roles of eph receptors and ephrins in neural development , 2001, Nature Reviews Neuroscience.

[203]  T. Kennedy,et al.  The Netrin-1 Receptor DCC Promotes Filopodia Formation and Cell Spreading by Activating Cdc42 and Rac1 , 2002, Molecular and Cellular Neuroscience.

[204]  D. Bredesen,et al.  Netrin-1 controls colorectal tumorigenesis by regulating apoptosis , 2004, Nature.

[205]  M. Tessier-Lavigne,et al.  Slit proteins: key regulators of axon guidance, axonal branching, and cell migration , 2000, Current Opinion in Neurobiology.

[206]  L. Richards,et al.  Directed Growth of Early Cortical Axons Is Influenced by a Chemoattractant Released from an Intermediate Target , 1997, The Journal of Neuroscience.

[207]  T. Pawson,et al.  UNC-5 function requires phosphorylation of cytoplasmic tyrosine 482, but its UNC-40-independent functions also require a region between the ZU-5 and death domains. , 2002, Developmental biology.

[208]  S. Strittmatter,et al.  Semaphorin-mediated axonal guidance via Rho-related G proteins. , 2001, Current opinion in cell biology.

[209]  M. Frotscher,et al.  A role for Cajal–Retzius cells and reelin in the development of hippocampal connections , 1997, Nature.

[210]  E. Nishida,et al.  ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1 , 2001, Nature Cell Biology.

[211]  J. Flanagan Life on the road , 1999, Nature.

[212]  M. Schachner,et al.  Analysis of the L1-Deficient Mouse Phenotype Reveals Cross-Talk between Sema3A and L1 Signaling Pathways in Axonal Guidance , 2000, Neuron.

[213]  Giovanni Romeo,et al.  The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[214]  M. Barbacid,et al.  Ephrins and their Eph receptors: multitalented directors of embryonic development , 1999, The EMBO journal.

[215]  P. Fort,et al.  Distinct roles of Rac1/Cdc42 and Rho/Rock for axon outgrowth and nucleokinesis of precerebellar neurons toward netrin 1 , 2004, Development.

[216]  B. Pedrotti,et al.  Dephosphorylated but not phosphorylated microtubule associated protein MAP1B binds to microfilaments , 1996, FEBS letters.

[217]  D. Engelkamp Cloning of three mouse Unc5 genes and their expression patterns at mid-gestation , 2002, Mechanisms of Development.

[218]  Roger Keynes,et al.  Axon guidance to and from choice points , 1998, Current Opinion in Neurobiology.

[219]  Cori Bargmann,et al.  Shared receptors in axon guidance: SAX-3/Robo signals via UNC-34/Enabled and a Netrin-independent UNC-40/DCC function , 2002, Nature Neuroscience.

[220]  C. Goodman,et al.  The Molecular Biology of Axon Guidance , 1996, Science.

[221]  C. Holt,et al.  Target selection: invasion, mapping and cell choice , 1998, Current Opinion in Neurobiology.

[222]  P. Caroni Driving the Growth Cone , 1998, Science.

[223]  L. Hinck,et al.  Surface Expression of the Netrin Receptor UNC5H1 Is Regulated through a Protein Kinase C-Interacting Protein/Protein Kinase-Dependent Mechanism , 2003, The Journal of Neuroscience.

[224]  S. Itohara,et al.  Netrin-G1: a Novel Glycosyl Phosphatidylinositol-Linked Mammalian Netrin That Is Functionally Divergent from Classical Netrins , 2000, The Journal of Neuroscience.

[225]  E. Nishida,et al.  Induction of neurite outgrowth by MAP kinase in PC12 cells. , 1995, Oncogene.

[226]  S. Guthrie Axon guidance: Netrin receptors are revealed , 1997, Current Biology.

[227]  M. Schachner,et al.  Microtubule reorganization is obligatory for growth cone turning. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[228]  S. Zipursky,et al.  Neuronal target recognition , 1995, Cell.

[229]  F. Walsh,et al.  Neural cell adhesion molecules of the immunoglobulin superfamily: role in axon growth and guidance. , 1997, Annual review of cell and developmental biology.

[230]  Philippe Soriano,et al.  Compartmentalized signaling by GPI-anchored ephrin-A5 requires the Fyn tyrosine kinase to regulate cellular adhesion. , 1999, Genes & development.

[231]  S. Itohara,et al.  Complementary expression and neurite outgrowth activity of netrin-G subfamily members , 2002, Mechanisms of Development.

[232]  N. Yamamoto,et al.  Wiring of the brain by a range of guidance cues , 2002, Progress in Neurobiology.

[233]  R. Weinberg,et al.  Phenotype of mice lacking functional Deleted in colorectal cancer (Dec) gene , 1997, Nature.

[234]  C. Holt,et al.  Chemotropic Responses of Retinal Growth Cones Mediated by Rapid Local Protein Synthesis and Degradation , 2001, Neuron.

[235]  L. Richards,et al.  The spatial and temporal expression patterns of netrin receptors, DCC and neogenin, in the developing mouse retina. , 2000, Experimental eye research.

[236]  J. Minna,et al.  SLIT2, a human homologue of the Drosophila Slit2 gene, has tumor suppressor activity and is frequently inactivated in lung and breast cancers. , 2002, Cancer research.

[237]  Marc Tessier-Lavigne,et al.  Conservation and divergence of axon guidance mechanisms , 1999, Current Opinion in Neurobiology.

[238]  A. W. Schaefer,et al.  Filopodia and actin arcs guide the assembly and transport of two populations of microtubules with unique dynamic parameters in neuronal growth cones , 2002, The Journal of cell biology.

[239]  C. Goodman,et al.  Slit Proteins Bind Robo Receptors and Have an Evolutionarily Conserved Role in Repulsive Axon Guidance , 1999, Cell.

[240]  Stefan A. Przyborski,et al.  The mouse rostral cerebellar malformation gene encodes an UNC-5-like protein , 1997, Nature.

[241]  D. Leahy,et al.  Netrin Binds Discrete Subdomains of DCC and UNC5 and Mediates Interactions between DCC and Heparin* , 2003, Journal of Biological Chemistry.

[242]  M. Tessier-Lavigne,et al.  Netrin-1-mediated axon outgrowth requires deleted in colorectal cancer-dependent MAPK activation , 2002, Nature.

[243]  F. J. Livesey Netrins and netrin receptorsRID="†"ID="†" Review , 1999, Cellular and Molecular Life Sciences CMLS.

[244]  Kathleen R. Cho,et al.  Identification of a chromosome 18q gene that is altered in colorectal cancers. , 1990, Science.

[245]  V. Berezin,et al.  Neural Cell Adhesion Molecule-Stimulated Neurite Outgrowth Depends on Activation of Protein Kinase C and the Ras–Mitogen-Activated Protein Kinase Pathway , 2000, The Journal of Neuroscience.

[246]  C. E. Holt,et al.  Age-related changes underlie switch in netrin-1 responsiveness as growth cones advance along visual pathway , 2002, Nature Neuroscience.

[247]  M. Tessier-Lavigne,et al.  En passant neurotrophic action of an intermediate axonal target in the developing mammalian CNS , 1999, Nature.

[248]  M. Poo,et al.  Cyclic AMP/GMP-dependent modulation of Ca2+ channels sets the polarity of nerve growth-cone turning , 2003, Nature.

[249]  Hiroshi Takahashi,et al.  Axonal Growth from the Habenular Nucleus along the Neuromere Boundary Region of the Diencephalon Is Regulated by Semaphorin 3F and Netrin-1 , 2000, Molecular and Cellular Neuroscience.

[250]  F. J. Livesey,et al.  Netrin and Netrin Receptor Expression in the Embryonic Mammalian Nervous System Suggests Roles in Retinal, Striatal, Nigral, and Cerebellar Development , 1997, Molecular and Cellular Neuroscience.

[251]  A. Barzilai,et al.  Semaphorins as Mediators of Neuronal Apoptosis , 1999, Journal of neurochemistry.

[252]  A. McMahon,et al.  The Morphogen Sonic Hedgehog Is an Axonal Chemoattractant that Collaborates with Netrin-1 in Midline Axon Guidance , 2003, Cell.

[253]  J. Challacombe,et al.  Dynamic Microtubule Ends Are Required for Growth Cone Turning to Avoid an Inhibitory Guidance Cue , 1997, The Journal of Neuroscience.

[254]  F. Murakami,et al.  Guidance of Circumferentially Growing Axons by Netrin-Dependent and -Independent Floor Plate Chemotropism in the Vertebrate Brain , 1996, Neuron.

[255]  N. Assa‐Munt,et al.  p75NTR and the concept of cellular dependence: seeing how the other half die , 1998, Cell Death and Differentiation.

[256]  Marc Tessier-Lavigne,et al.  Extension of Long Leading Processes and Neuronal Migration in the Mammalian Brain Directed by the Chemoattractant Netrin-1 , 1999, Neuron.

[257]  H. Pearson Drug discovery: In the eye of the beholder , 2003, Nature.

[258]  M. Kirschner,et al.  The role of microtubules in growth cone turning at substrate boundaries , 1995, The Journal of cell biology.

[259]  M. Seeger,et al.  Guidance Cues at the Drosophila CNS Midline: Identification and Characterization of Two Drosophila Netrin/UNC-6 Homologs , 1996, Neuron.

[260]  R. Burgeson,et al.  A Novel Member of the Netrin Family, β-Netrin, Shares Homology with the β Chain of Laminin , 2000, The Journal of cell biology.

[261]  Mu-ming Poo,et al.  cAMP-Dependent Growth Cone Guidance by Netrin-1 , 1997, Neuron.

[262]  Moving On , 2001, Science.

[263]  Philippe P Roux,et al.  Protein Kinase A Activation Promotes Plasma Membrane Insertion of DCC from an Intracellular Pool: A Novel Mechanism Regulating Commissural Axon Extension , 2004, The Journal of Neuroscience.

[264]  P. Gruss,et al.  Netrin 1 is required for semicircular canal formation in the mouse inner ear. , 2000, Development.

[265]  R. Sperry CHEMOAFFINITY IN THE ORDERLY GROWTH OF NERVE FIBER PATTERNS AND CONNECTIONS. , 1963, Proceedings of the National Academy of Sciences of the United States of America.

[266]  M. Poo,et al.  Phospholipase C-γ and Phosphoinositide 3-Kinase Mediate Cytoplasmic Signaling in Nerve Growth Cone Guidance , 1999, Neuron.

[267]  Shahrooz Rabizadeh,et al.  The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis , 1998, Nature.

[268]  M. Schachner,et al.  NCAM stimulates the Ras-MAPK pathway and CREB phosphorylation in neuronal cells. , 1999, Journal of neurobiology.