Clinical approach to the critically ill, morbidly obese patient.

In the absence of a national registry, the prevalence of critically ill, morbidly obese patients in the United States is not known. On the basis of a retrospective study spanning 7 years of intensive care unit (ICU) data (1994–2000), it is estimated that the incidence of morbidly obese patients requiring intensive care treatment approaches 14 cases per 1,000 ICU admissions per year (1). However, this figure is likely to underestimate the true incidence because the database was restricted to nonsurgical patients. The growing interest in gastric bypass underlines the increased public awareness of the medical and economic consequences of this epidemic. The latest numbers released by the American Society for Bariatric Surgery indicate that the rate of bariatric surgeries has risen in the United States alone from 37,000 cases in the year 2000 to 62,400 cases in 2001 and it is expected that the total number of cases may exceed 100,000 by the end of 2003 (2). Most of the reviews that have provided data on morbidly obese patients have focused on the impact of obesity on individual organ function. Yet, clinical investigations addressing the care of the critically ill, morbidly obese patient are scarce. A recent review published in the AJRCCM detailed the principles and approach to outpatient treatment of obesity (3). The present commentary is aimed at (1) describing the common challenges of treating morbidly obese patients in critical care settings and (2) reviewing the current concepts and suggestions for therapy.

[1]  T. Bates,et al.  The use of the Body Mass Index in studies of abdominal wound infection. , 1992, The Journal of hospital infection.

[2]  S. Burns,et al.  Effect of body position on spontaneous respiratory rate and tidal volume in patients with obesity, abdominal distension and ascites. , 1994, American journal of critical care : an official publication, American Association of Critical-Care Nurses.

[3]  J. Brock‐Utne,et al.  Morbid Obesity and Tracheal Intubation , 2002, Anesthesia and analgesia.

[4]  J. Helterbrand,et al.  Pharmacokinetic‐pharmacodynamic analysis of drotrecogin alfa (activated) in patients with severe sepsis , 2002, Clinical pharmacology and therapeutics.

[5]  G. Bailie,et al.  Pharmacokinetics of propofol during and after long-term continuous infusion for maintenance of sedation in ICU patients. , 1992, British journal of anaesthesia.

[6]  P. Wade,et al.  Sedation in the Intensive-care Unit , 1984, The Lancet.

[7]  P. Dodek,et al.  Intravenous insulin nomogram improves blood glucose control in the critically ill , 2001, Critical care medicine.

[8]  A. El‐Solh,et al.  Morbid obesity in the medical ICU. , 2001, Chest.

[9]  H. Sugerman,et al.  Risks and Benefits of Gastric Bypass in Morbidly Obese Patients With Severe Venous Stasis Disease , 2001, Annals of surgery.

[10]  S. Nasraway,et al.  Practice parameters for intravenous analgesia and sedation for adult patients in the intensive care unit: an executive summary. Society of Critical Care Medicine. , 1995, Critical care medicine.

[11]  L. Hidalgo Dermatological Complications of Obesity , 2002 .

[12]  J. Kress,et al.  Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. , 2000, The New England journal of medicine.

[13]  M. Laposata,et al.  College of American Pathologists Conference XXXI on laboratory monitoring of anticoagulant therapy: the clinical use and laboratory monitoring of low-molecular-weight heparin, danaparoid, hirudin and related compounds, and argatroban. , 1998, Archives of Pathology & Laboratory Medicine.

[14]  T. Ishizaki,et al.  Propofol decreases the clearance of midazolam by inhibiting CYP3A4: an in vivo and in vitro study , 1999, Clinical pharmacology and therapeutics.

[15]  K. Rodvold,et al.  Antimicrobial dosing in obese patients. , 1997, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[16]  J. Barrett,et al.  Dosing in Heavy-weight/Obese Patients with the LMWH, Tinzaparin: A Pharmacodynamic Study , 2002, Thrombosis and Haemostasis.

[17]  G. L. Bloomfield,et al.  Abdominal compartment syndrome. , 1998, The Journal of trauma.

[18]  H. Sugerman,et al.  Intra‐abdominal pressure, sagittal abdominal diameter and obesity comorbidity , 1997, Journal of internal medicine.

[19]  G. Angelini,et al.  Use of propofol and other nonbenzodiazepine sedatives in the intensive care unit. , 2001, Critical care clinics.

[20]  R. Dickerson,et al.  Hypocaloric enteral tube feeding in critically ill obese patients. , 2002, Nutrition.

[21]  G. Foster Principles and practices in the management of obesity. , 2003, American journal of respiratory and critical care medicine.

[22]  J G Reves,et al.  Midazolam: Pharmacology and Uses , 1985, Anesthesiology.

[23]  B A Carroll,et al.  The diagnostic approach to acute venous thromboembolism. Clinical practice guideline. American Thoracic Society. , 1999, American journal of respiratory and critical care medicine.

[24]  D. Arnaudov,et al.  Validation Study of Two-microphone Acoustic Reflectometry for Determination of Breathing Tube Placement in 200 Adult Patients , 2002, Anesthesiology.

[25]  R. B. Becker,et al.  Facilitation of internal jugular venous cannulation using an audio-guided Doppler ultrasound vascular access device: results from a prospective, dual-center, randomized, crossover clinical study. , 1995, Critical care medicine.

[26]  M. Ellersieck,et al.  Predicting energy needs in ventilator-dependent critically ill patients: effect of adjusting weight for edema or adiposity. , 1997, The American journal of clinical nutrition.

[27]  M. Naguib,et al.  Predictive models for difficult laryngoscopy and intubation. A clinical, radiologic and three-dimensional computer imaging study , 1999, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

[28]  H. Brem,et al.  Pressure ulcers in the chronically critically ill patient. , 2002, Critical care clinics.

[29]  P. Choban,et al.  The impact of obesity on surgical outcomes: a review. , 1997, Journal of the American College of Surgeons.

[30]  I. Kehagias,et al.  Prophylaxis of Venous Thromboembolism Using Two Different Doses of Low-Molecular-Weight Heparin (Nadroparin) in Bariatric Surgery: A Prospective Randomized Trial , 2001, Obesity surgery.

[31]  G. Barat,et al.  Positive end‐expiratory pressure , 1975, Anaesthesia.

[32]  W. Pories,et al.  Prophylactic cefazolin in gastric bypass surgery. , 1981, Surgery.

[33]  C A Beam,et al.  1992 ARRS Executive Council Award. Detection of deep venous thrombosis: prospective comparison of MR imaging with contrast venography. , 1993, AJR. American journal of roentgenology.

[34]  N. Rawal,et al.  Comparison of Intramuscular and Epidural Morphine for Postoperative Analgesia in the Grossly Obese: Influence on Postoperative Ambulation and Pulmonary Function , 1984, Anesthesia and analgesia.

[35]  P. Pelosi,et al.  Total respiratory system, lung, and chest wall mechanics in sedated-paralyzed postoperative morbidly obese patients. , 1996, Chest.

[36]  A. Ernst,et al.  Safety of bedside percutaneous dilatational tracheostomy in obese patients in the ICU. , 2000, Chest.

[37]  C. Ireton-Jones,et al.  Obesity: nutrition support practice and application to critical care. , 1995, Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition.

[38]  J. Canet,et al.  Acid aspiration prophylaxis in morbidly obese patients: famotidine vs. ranitidine , 1991, Anaesthesia.

[39]  G. Adams,et al.  Permanent tracheostomy with cervical lipectomy , 1990, The Laryngoscope.

[40]  R. K. Webb,et al.  Difficult Intubation: An Analysis of 2000 Incident Reports , 1993 .

[41]  M. Ramsay,et al.  Controlled Sedation with Alphaxalone-Alphadolone , 1974, British medical journal.

[42]  J. Cardella,et al.  Interventional radiologic placement of peripherally inserted central catheters. , 1993, Journal of Vascular and Interventional Radiology.

[43]  M. Jeevanandam,et al.  Obesity and the metabolic response to severe multiple trauma in man. , 1991, The Journal of clinical investigation.

[44]  M. Lamy,et al.  Effect of bi-level positive airway pressure (BiPAP) nasal ventilation on the postoperative pulmonary restrictive syndrome in obese patients undergoing gastroplasty. , 1997, Chest.

[45]  F. Donati,et al.  Influence of extreme obesity on the body disposition and neuromuscular blocking effect of atracurium , 1990, Clinical pharmacology and therapeutics.

[46]  R. Vaughan,et al.  Volume and pH of gastric juice in obese patients. , 1975, Anesthesiology.

[47]  M. Robson,et al.  Becaplermin gel in the treatment of pressure ulcers: a phase II randomized, double‐blind, placebo‐controlled study , 1999, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[48]  C. Ireton-Jones,et al.  Actual or ideal body weight: which should be used to predict energy expenditure? , 1991, Journal of the American Dietetic Association.

[49]  B. Ghorayeb Tracheotomy in the morbidly obese patient. , 1987, Archives of otolaryngology--head & neck surgery.

[50]  Mayank Patel,et al.  Critical care of the obese and bariatric surgical patient. , 2003, Critical care clinics.

[51]  R. Farinotti,et al.  Propofol Infusion for Maintenance of Anesthesia in Morbidly Obese Patients Receiving Nitrous Oxide A Clinical and Pharmacokinetic Study , 1993, Anesthesiology.

[52]  E. A. Nelson,et al.  Systematic reviews of wound care management: (5) beds; (6) compression; (7) laser therapy, therapeutic ultrasound, electrotherapy and electromagnetic therapy. , 2001, Health technology assessment.

[53]  M Schetz,et al.  Intensive insulin therapy in critically ill patients. , 2001, The New England journal of medicine.

[54]  E. Nutescu,et al.  Dosing and Monitoring of Low‐Molecular‐Weight Heparins in Special Populations , 2001, Pharmacotherapy.

[55]  A. Giles,et al.  College of American Pathologists Conference XXXI on Laboratory Monitoring of Anticoagulant Therapy , 1998 .

[56]  B. Bistrian,et al.  Intensive insulin therapy in critically ill patients. , 2002, The New England journal of medicine.

[57]  B. Boutouyrie,et al.  The pharmacokinetics and pharmacodynamics of enoxaparin in obese volunteers , 2002, Clinical pharmacology and therapeutics.

[58]  M. Herrera,et al.  Role of Radiologic Contrast Studies in the Early Postoperative Period After Bariatric Surgery , 1999, Obesity surgery.

[59]  G. Guyatt,et al.  Adaptation to the Intensive Care Environment (ATICE): Development and validation of a new sedation assessment instrument , 2003, Critical care medicine.

[60]  M. Armstrong Obesity as an intrinsic factor affecting wound healing. , 1998, Journal of wound care.

[61]  D. Scholten,et al.  A Comparison of Two Different Prophylactic Dose Regimens of Low Molecular Weight Heparin in Bariatric Surgery , 2002, Obesity surgery.

[62]  G. Cheymol Effects of Obesity on Pharmacokinetics , 2000 .

[63]  K. Mizutani,et al.  Fentanyl inhibits metabolism of midazolam: competitive inhibition of CYP3A4 in vitro. , 1999, British journal of anaesthesia.

[64]  J. Helterbrand,et al.  Efficacy and safety of recombinant human activated protein C for severe sepsis , 2003 .

[65]  Deborah H. Kim Practice Parameters for Intravenous Analgesia and Sedation for Adult Patients in the Intensive Care Unit: An Executive Summary , 1996 .