Fabrication and applications of large arrays of multifunctional rolled-up SiO/SiO2 microtubes

Biocompatible, multifunctional large arrays of transparent SiO/SiO2 microtubes are fabricated by rolled-up nanotech. The outer tubular diameter as a function of thicknesses of SiO and SiO2 has been systematically studied and the roll-up parameters have been optimized to deterministically achieve a yield of nearly 100%. A macroscopic continuum mechanical model is in good agreement with the experimental data. The relative ease in functionalization of the “glass” microtubes with different biomaterials renders rolled-up nanotech an excellent option for various on- and off-chip applications, including optofluidic sensors, micro-engines and pre-patterned 3D scaffolds for cell culturing.

[1]  J. Pivot Mechanical properties of SiOx thin films , 1982 .

[2]  S M Schwartz,et al.  Developmental mechanisms underlying pathology of arteries. , 1990, Physiological reviews.

[3]  Stephen Britland,et al.  Morphogenetic guidance cues can interact synergistically and hierarchically in steering nerve cell growth , 1996 .

[4]  Giovanni Carlotti,et al.  Elastic properties of silicon dioxide films deposited by chemical vapour deposition from tetraethylorthosilicate , 1997 .

[5]  A Curtis,et al.  Topographical control of cells. , 1997, Biomaterials.

[6]  G. Whitesides,et al.  Rapid Prototyping of Microfluidic Systems in Poly(dimethylsiloxane). , 1998, Analytical chemistry.

[7]  P. Hordijk,et al.  Vascular-endothelial-cadherin modulates endothelial monolayer permeability. , 1999, Journal of cell science.

[8]  Gabriel Fenteany,et al.  Signaling pathways and cell mechanics involved in wound closure by epithelial cell sheets , 2000, Current Biology.

[9]  M. A. Putyato,et al.  Free-standing and overgrown InGaAs/GaAs nanotubes, nanohelices and their arrays , 2000 .

[10]  O. Schmidt,et al.  Nanotechnology: Thin solid films roll up into nanotubes , 2001, Nature.

[11]  D. Ingber Mechanical signaling and the cellular response to extracellular matrix in angiogenesis and cardiovascular physiology. , 2002, Circulation research.

[12]  J. Heitmann,et al.  Si rings, Si clusters, and Si nanocrystals—different states of ultrathin SiOx layers , 2002 .

[13]  Chun-Hway Hsueh Modeling of Elastic Deformation of Multilayers Due to Residual Stresses and External Bending , 2002 .

[14]  Oliver G. Schmidt,et al.  Diameter scalability of rolled-up In(Ga)As/GaAs nanotubes , 2002 .

[15]  Christopher S. Chen,et al.  Cells lying on a bed of microneedles: An approach to isolate mechanical force , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[16]  Keith R. Johnson,et al.  Cadherin-mediated cellular signaling. , 2003, Current opinion in cell biology.

[17]  Marius Grundmann,et al.  Nanoscroll formation from strained layer heterostructures , 2003 .

[18]  O. Schmidt,et al.  Real-time formation, accurate positioning, and fluid filling of single rolled-up nanotubes , 2004 .

[19]  Julian H. George,et al.  Exploring and Engineering the Cell Surface Interface , 2005, Science.

[20]  Oliver G. Schmidt,et al.  Process integration of microtubes for fluidic applications , 2006 .

[21]  Daniel A Fletcher,et al.  Tissue Geometry Determines Sites of Mammary Branching Morphogenesis in Organotypic Cultures , 2006, Science.

[22]  Oliver G. Schmidt,et al.  Semiconductor Sub‐Micro‐/ Nanochannel Networks by Deterministic Layer Wrinkling , 2006 .

[23]  A. Khademhosseini,et al.  Microscale technologies for tissue engineering and biology. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[24]  Xudong Fan,et al.  Integrated multiplexed biosensors based on liquid core optical ring resonators and antiresonant reflecting optical waveguides , 2006 .

[25]  SiOx∕Si radial superlattices and microtube optical ring resonators , 2006, cond-mat/0611261.

[26]  Ian M. White,et al.  An opto-fluidic ring resonator biosensor for the detection of organophosphorus pesticides , 2008 .

[27]  George M Whitesides,et al.  Fabrication of a modular tissue construct in a microfluidic chip. , 2008, Lab on a chip.

[28]  Oliver G. Schmidt,et al.  Versatile Approach for Integrative and Functionalized Tubes by Strain Engineering of Nanomembranes on Polymers , 2008 .

[29]  Hongying Zhu,et al.  Phage-based label-free biomolecule detection in an opto-fluidic ring resonator. , 2008, Biosensors & bioelectronics.

[30]  Oliver G. Schmidt,et al.  On-chip Si/SiOx microtube refractometer , 2008 .

[31]  O. Schmidt,et al.  Optical properties of rolled-up tubular microcavities from shaped nanomembranes , 2009 .

[32]  B. Geiger,et al.  Environmental sensing through focal adhesions , 2009, Nature Reviews Molecular Cell Biology.

[33]  Oliver G Schmidt,et al.  Rolled-up transparent microtubes as two-dimensionally confined culture scaffolds of individual yeast cells. , 2009, Lab on a chip.

[34]  O. Schmidt,et al.  Catalytic microtubular jet engines self-propelled by accumulated gas bubbles. , 2009, Small.

[35]  Martin Pumera,et al.  Magnetic Control of Tubular Catalytic Microbots for the Transport, Assembly, and Delivery of Micro‐objects , 2010 .

[36]  Samuel Sanchez,et al.  Dynamics of biocatalytic microengines mediated by variable friction control. , 2010, Journal of the American Chemical Society.

[37]  Oliver G. Schmidt,et al.  Morphological Differentiation of Neurons on Microtopographic Substrates Fabricated by Rolled‐Up Nanotechnology , 2010 .

[38]  Yongfeng Mei,et al.  Rolled-up optical microcavities with subwavelength wall thicknesses for enhanced liquid sensing applications. , 2010, ACS nano.

[39]  M. Möller,et al.  Evaporation and Condensation of SiO and SiO2 Studied by Infrared Spectroscopy , 2010, Applied spectroscopy.

[40]  Daniil Karnaushenko,et al.  Rolled-up magnetic sensor: nanomembrane architecture for in-flow detection of magnetic objects. , 2011, ACS nano.

[41]  Oliver G. Schmidt,et al.  Rolled-up nanotech on polymers: from basic perception to self-propelled catalytic microengines. , 2011, Chemical Society reviews.

[42]  Samuel Sanchez,et al.  Lab-in-a-tube: detection of individual mouse cells for analysis in flexible split-wall microtube resonator sensors. , 2011, Nano letters.

[43]  O. Schmidt,et al.  Microbots swimming in the flowing streams of microfluidic channels. , 2011, Journal of the American Chemical Society.

[44]  Filiz Kuralay,et al.  Functionalized micromachines for selective and rapid isolation of nucleic acid targets from complex samples. , 2011, Nano letters.

[45]  Leonid Ionov,et al.  Fully biodegradable self-rolled polymer tubes: a candidate for tissue engineering scaffolds. , 2011, Biomacromolecules.

[46]  O. Schmidt,et al.  Superfast motion of catalytic microjet engines at physiological temperature. , 2011, Journal of the American Chemical Society.

[47]  Robert H Blick,et al.  Semiconductor nanomembrane tubes: three-dimensional confinement for controlled neurite outgrowth. , 2011, ACS nano.

[48]  O. Schmidt,et al.  Tunable catalytic tubular micro-pumps operating at low concentrations of hydrogen peroxide. , 2011, Physical chemistry chemical physics : PCCP.

[49]  Marion Ghibaudo,et al.  Mechanics of cell spreading within 3D-micropatterned environments. , 2011, Lab on a chip.

[50]  Susana Campuzano,et al.  Micromachine-enabled capture and isolation of cancer cells in complex media. , 2011, Angewandte Chemie.

[51]  Martin Pumera,et al.  Nanomaterials meet microfluidics. , 2011, Chemical communications.

[52]  Samuel Sanchez,et al.  Controlled manipulation of multiple cells using catalytic microbots. , 2011, Chemical communications.