The Warburg effect and its cancer therapeutic implications
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Peng Huang | Peng Huang | Weiqin Lu | Zhao Chen | Weiqin Lu | Celia Garcia-Prieto | C. García-Prieto | Zhao Chen
[1] J. Chesney. 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase and tumor cell glycolysis , 2006, Current opinion in clinical nutrition and metabolic care.
[2] Saroj P. Mathupala,et al. Hexokinase II: Cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria , 2006, Oncogene.
[3] N. Hay,et al. Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt , 2006, Oncogene.
[4] H. Pelicano,et al. Glycolysis inhibition for anticancer treatment , 2006, Oncogene.
[5] Marty C. Brandon,et al. Mitochondrial mutations in cancer , 2006, Oncogene.
[6] Eyal Gottlieb,et al. TIGAR, a p53-Inducible Regulator of Glycolysis and Apoptosis , 2006, Cell.
[7] Oksana Gavrilova,et al. p53 Regulates Mitochondrial Respiration , 2006, Science.
[8] P. Leder,et al. Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance. , 2006, Cancer cell.
[9] R. Moreno-Sánchez,et al. Determining and understanding the control of glycolysis in fast‐growth tumor cells , 2006, The FEBS journal.
[10] K. Ginalski,et al. Efficacy of 2-halogen substituted d-glucose analogs in blocking glycolysis and killing “hypoxic tumor cells” , 2006, Cancer Chemotherapy and Pharmacology.
[11] G. Semenza,et al. HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. , 2006, Cell metabolism.
[12] H. Pelicano,et al. Synergistic effect of targeting mTOR by rapamycin and depleting ATP by inhibition of glycolysis in lymphoma and leukemia cells , 2005, Leukemia.
[13] Eyal Gottlieb,et al. Mitochondrial tumour suppressors: a genetic and biochemical update , 2005, Nature Reviews Cancer.
[14] T. Lazar Mathew,et al. Optimizing Cancer Radiotherapy with 2-Deoxy-D-Glucose , 2005, Strahlentherapie und Onkologie.
[15] K. Takata,et al. Hexokinase-II expression in untreated oral squamous cell carcinoma: Comparison with FDG PET imaging , 2005, Annals of nuclear medicine.
[16] M. Sirover. New nuclear functions of the glycolytic protein, glyceraldehyde‐3‐phosphate dehydrogenase, in mammalian cells , 2005, Journal of cellular biochemistry.
[17] S. Schreiber,et al. Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[18] Peng Huang,et al. Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia. , 2005, Cancer research.
[19] Okio Hino,et al. A mutation in the SDHC gene of complex II increases oxidative stress, resulting in apoptosis and tumorigenesis. , 2005, Cancer research.
[20] Manuel Hidalgo,et al. Matrix metalloproteinase-2 contributes to cancer cell migration on collagen. , 2005, Cancer research.
[21] K. Greulich,et al. Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes. , 2004, Genomics.
[22] Martin G Pomper,et al. Advanced cancers: eradication in all cases using 3-bromopyruvate therapy to deplete ATP. , 2004, Biochemical and biophysical research communications.
[23] R. Gillies,et al. Why do cancers have high aerobic glycolysis? , 2004, Nature Reviews Cancer.
[24] S. Gottschalk,et al. Imatinib (STI571)-Mediated Changes in Glucose Metabolism in Human Leukemia BCR-ABL-Positive Cells , 2004, Clinical Cancer Research.
[25] Keshav K. Singh. Mitochondrial Dysfunction Is a Common Phenotype in Aging and Cancer , 2004, Annals of the New York Academy of Sciences.
[26] G. Giaccone,et al. Glufosfamide administered by 1-hour infusion as a second-line treatment for advanced non-small cell lung cancer; a phase II trial of the EORTC-New Drug Development Group. , 2004, European Journal of Cancer.
[27] Awtar Krishan,et al. Greater cell cycle inhibition and cytotoxicity induced by 2-deoxy-d-glucose in tumor cells treated under hypoxic vs aerobic conditions , 2004, Cancer Chemotherapy and Pharmacology.
[28] N. Savaraj,et al. 2-Deoxy-d-glucose Increases the Efficacy of Adriamycin and Paclitaxel in Human Osteosarcoma and Non-Small Cell Lung Cancers In Vivo , 2004, Cancer Research.
[29] D. Lacombe,et al. Glufosfamide administered using a 1-hour infusion given as first-line treatment for advanced pancreatic cancer. A phase II trial of the EORTC-new drug development group. , 2003, European journal of cancer.
[30] P. Hammerman,et al. Akt-Directed Glucose Metabolism Can Prevent Bax Conformation Change and Promote Growth Factor-Independent Survival , 2003, Molecular and Cellular Biology.
[31] S. Grimm,et al. The tumor suppressor cybL, a component of the respiratory chain, mediates apoptosis induction. , 2003, Molecular biology of the cell.
[32] Peng Huang,et al. Mitochondrial DNA mutations in primary leukemia cells after chemotherapy: clinical significance and therapeutic implications , 2003, Leukemia.
[33] John Eric Wilson. Isozymes of mammalian hexokinase: structure, subcellular localization and metabolic function , 2003, Journal of Experimental Biology.
[34] Paolo Carlini,et al. Lonidamine: efficacy and safety in clinical trials for the treatment of solid tumors. , 2003, Drugs of today.
[35] N. Savaraj,et al. Hypoxia increases tumor cell sensitivity to glycolytic inhibitors: a strategy for solid tumor therapy (Model C). , 2002, Biochemical pharmacology.
[36] Peng Huang,et al. Mitochondrial defects in cancer , 2002, Molecular Cancer.
[37] P. Bruzzi,et al. Time to progression in metastatic breast cancer patients treated with epirubicin is not improved by the addition of either cisplatin or lonidamine: final results of a phase III study with a factorial design. , 2002, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[38] Saroj P. Mathupala,et al. Mitochondrial bound type II hexokinase: a key player in the growth and survival of many cancers and an ideal prospect for therapeutic intervention. , 2002, Biochimica et biophysica acta.
[39] P. Pedersen,et al. Novel therapy for liver cancer: direct intraarterial injection of a potent inhibitor of ATP production. , 2002, Cancer research.
[40] C. Schmidt. Bench and Bedside , 2002, Molecular Cancer.
[41] P. Pedersen,et al. Glucose catabolism in the rabbit VX2 tumor model for liver cancer: characterization and targeting hexokinase. , 2001, Cancer letters.
[42] I. Roninson,et al. Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. , 2001, Genes & development.
[43] E. Kandel,et al. Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase. , 2001, Genes & development.
[44] N. Savaraj,et al. Hypersensitization of tumor cells to glycolytic inhibitors. , 2001, Biochemistry.
[45] R. Moreno-Sánchez,et al. Substrate oxidation and ATP supply in AS-30D hepatoma cells. , 2000, Archives of biochemistry and biophysics.
[46] John Eric Wilson,et al. Characterization of the Rat Type III Hexokinase Gene Promoter , 1999, The Journal of Biological Chemistry.
[47] M. Cascante,et al. Oxythiamine and dehydroepiandrosterone induce a G1 phase cycle arrest in Ehrlich's tumor cells through inhibition of the pentose cycle , 1999, FEBS letters.
[48] T. Bruno,et al. Enhancement of doxorubicin content by the antitumor drug lonidamine in resistant Ehrlich ascites tumor cells through modulation of energy metabolism. , 1998, Biochemical pharmacology.
[49] V. Bakanauskas,et al. Effect of oncogene transformation of rat embryo cells on cellular oxygen consumption and glycolysis. , 1997, Biochemical and biophysical research communications.
[50] Karl Brand,et al. Aerobic glycolysis by proliferating cells: a protective strategy against reactive oxygen species 1 , 1997, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[51] B. Burgering,et al. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction , 1995, Nature.
[52] Saroj P. Mathupala,et al. Glucose Catabolism in Cancer Cells. , 1995, The Journal of Biological Chemistry.
[53] P. Pedersen,et al. Glucose catabolism in African trypanosomes. Evidence that the terminal step is catalyzed by a pyruvate transporter capable of facilitating uptake of toxic analogs. , 1993, The Journal of biological chemistry.
[54] H. Terada,et al. Remarkably enhanced expression of the type II hexokinase in rat hepatoma cell line AH130 , 1991, FEBS letters.
[55] P. Pedersen,et al. Functional significance of mitochondrial bound hexokinase in tumor cell metabolism. Evidence for preferential phosphorylation of glucose by intramitochondrially generated ATP. , 1988, The Journal of biological chemistry.
[56] H. Lodish,et al. Elevated levels of glucose transport and transporter messenger RNA are induced by ras or src oncogenes. , 1987, Science.
[57] P. Pedersen,et al. Contributions of glycolysis and oxidative phosphorylation to adenosine 5'-triphosphate production in AS-30D hepatoma cells. , 1984, Cancer research.
[58] B. Silvestrini,et al. Lonidamine, a selective inhibitor of aerobic glycolysis of murine tumor cells. , 1981, Journal of the National Cancer Institute.
[59] G. Brierley,et al. Induction of K+ transport in isolated heart mitochondria by zinc ions. , 1966, Biochemical and biophysical research communications.
[60] O. Warburg. [Origin of cancer cells]. , 1956, Oncologia.
[61] P. Schubert,et al. Mutations in the transketolase-like gene TKTL1: clinical implications for neurodegenerative diseases, diabetes and cancer. , 2005, Clinical laboratory.
[62] David G. Watson,et al. Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase. , 2005, Cancer cell.
[63] L. Boros,et al. Detection of Resistance to Imatinib by Metabolic Profiling , 2005, American journal of pharmacogenomics : genomics-related research in drug development and clinical practice.
[64] D. McConkey,et al. Increased mitochondrial biogenesis in primary leukemia cells: the role of endogenous nitric oxide and impact on sensitivity to fludarabine , 2004, Leukemia.
[65] B. Teicher,et al. Effect of lonidamine on the cytotoxicity of four alkylating agents in vitro , 2004, Cancer Chemotherapy and Pharmacology.
[66] Adrian L. Harris,et al. Hypoxia — a key regulatory factor in tumour growth , 2002, Nature Reviews Cancer.