Multimodal Phantom of Liver Tissue

Medical imaging plays an important role in patients' care and is continuously being used in managing health and disease. To obtain the maximum benefit from this rapidly developing technology, further research is needed. Ideally, this research should be done in a patient-safe and environment-friendly manner; for example, on phantoms. The goal of this work was to develop a protocol and manufacture a multimodal liver phantom that is suitable for ultrasound, computed tomography, and magnetic resonance imaging modalities. The proposed phantom consists of three types of mimicked soft tissues: liver parenchyma, tumors, and portal veins, that are made of six ingredients: candle gel, sephadex®, agarose, glycerol, distilled water, and silicone string. The entire procedure is advantageous, since preparation of the phantom is simple, rather cost-effective, and reasonably quick – it takes around 2 days. Besides, most of the phantom's parts can be reused to manufacture a new phantom. Comparison of ultrasound images of real patient's liver and the developed phantom shows that the phantom's liver tissue and its structures are well simulated.

[1]  S. Shalev,et al.  Development of a tissue-equivalent phantom for diaphanography. , 1986, Medical physics.

[2]  J. Iglehart Health insurers and medical-imaging policy--a work in progress. , 2009, The New England journal of medicine.

[3]  E. Madsen,et al.  Prospective tissue-mimicking materials for use in NMR imaging phantoms. , 1982, Magnetic resonance imaging.

[4]  Janne Beate Lervik Bakeng,et al.  CustusX: A Research Application for Image-Guided Therapy , 2011, The MIDAS Journal.

[5]  T. Kondo,et al.  New tissue mimicking materials for ultrasound phantoms , 2005, IEEE Ultrasonics Symposium, 2005..

[6]  S. Arridge,et al.  Estimation of optical pathlength through tissue from direct time of flight measurement , 1988 .

[7]  E. Madsen,et al.  Tissue mimicking materials for ultrasound phantoms. , 1978, Medical physics.

[8]  B. Angelsen,et al.  Utilizing dual frequency band transmit pulse complexes in medical ultrasound imaging. , 2010, The Journal of the Acoustical Society of America.

[9]  B. Pogue,et al.  Review of tissue simulating phantoms for optical spectroscopy, imaging and dosimetry. , 2006, Journal of biomedical optics.

[10]  M. Kuroda,et al.  Composition of MRI phantom equivalent to human tissues. , 2005, Medical physics.

[11]  T. Peters,et al.  Poly(vinyl alcohol) cryogel phantoms for use in ultrasound and MR imaging , 2004, Physics in medicine and biology.

[12]  T. Krouskop,et al.  Phantom materials for elastography , 1997, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[13]  Jane Bates,et al.  Abdominal ultrasound : how, why and when , 1999 .

[14]  M. V. van Gemert,et al.  Measurements and calculations of the energy fluence rate in a scattering and absorbing phantom at 633 nm. , 1989, Applied optics.

[15]  H. J. van Staveren,et al.  Light scattering in Intralipid-10% in the wavelength range of 400-1100 nm. , 1991, Applied optics.

[16]  D. Vray,et al.  Characterization of PVA cryogel for intravascular ultrasound elasticity imaging , 2003, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[17]  W. Zinth,et al.  Time-gated transillumination of biological tissues and tissuelike phantoms. , 1994, Applied optics.

[18]  T van Doorn,et al.  Optical transmission properties of homogenised milk used as a phantom material in visible wavelength imaging. , 1995, Australasian physical & engineering sciences in medicine.

[19]  P. Monnier,et al.  Three‐dimensional optical phantom and its application in photodynamic therapy , 1997, Lasers in surgery and medicine.

[20]  E. Ritenour,et al.  Medical Imaging Physics , 1992 .

[21]  S L Jacques,et al.  Optical properties of intralipid: A phantom medium for light propagation studies , 1992, Lasers in surgery and medicine.

[22]  R. Niessner,et al.  Acoustical properties of selected tissue phantom materials for ultrasound imaging , 2007, Physics in medicine and biology.

[23]  B G Steinbach,et al.  Use of a modified polysaccharide gel in developing a realistic breast phantom for MRI. , 1996, Magnetic resonance imaging.

[24]  E. Madsen,et al.  Tissue-mimicking phantom materials for narrowband and ultrawideband microwave applications , 2005, Physics in medicine and biology.

[25]  Martin O Culjat,et al.  A review of tissue substitutes for ultrasound imaging. , 2010, Ultrasound in medicine & biology.

[26]  Tim Lüth,et al.  The effects of real-time image navigation in operative liver surgery , 2011, International Journal of Computer Assisted Radiology and Surgery.

[27]  K E Fredfeldt,et al.  An easily made ultrasound biopsy phantom. , 1986, Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine.