Invadopodia associated Thrombospondin-1 contributes to a post-therapy pro-invasive response in glioblastoma cells.

[1]  J. Lawler,et al.  Thrombospondins in the tumor microenvironment. , 2023, Seminars in cell & developmental biology.

[2]  L. Perrin,et al.  Proteolytic and mechanical remodeling of the extracellular matrix by invadopodia in cancer , 2022, Physical biology.

[3]  S. Stylli,et al.  Repurposing FDA-approved drugs as inhibitors of therapy-induced invadopodia activity in glioblastoma cells , 2022, Molecular and Cellular Biochemistry.

[4]  J. Condeelis,et al.  Mechanisms and roles of podosomes and invadopodia , 2022, Nature Reviews Molecular Cell Biology.

[5]  S. Koizumi,et al.  Molecular Mechanisms and Clinical Challenges of Glioma Invasion , 2022, Brain sciences.

[6]  D. Hanahan.  Hallmarks of Cancer: New Dimensions. , 2022, Cancer discovery.

[7]  Jiangang Liu,et al.  Apatinib inhibits glioma cell malignancy in patient-derived orthotopic xenograft mouse model by targeting thrombospondin 1/myosin heavy chain 9 axis , 2021, Cell Death & Disease.

[8]  K. Bogunia-Kubik,et al.  Decreased Thrombospondin-1 and Bone Morphogenetic Protein-4 Serum Levels as Potential Indices of Advanced Stage Lung Cancer , 2021, Journal of clinical medicine.

[9]  Guoguang Zhao,et al.  Bioequivalence study of 20-mg and 100-mg temozolomide capsules (TOZ309 and Temodal®) in glioma patients in China , 2020, Cancer Chemotherapy and Pharmacology.

[10]  S. Stylli,et al.  Inhibition of Radiation and Temozolomide-Induced Glioblastoma Invadopodia Activity Using Ion Channel Drugs , 2020, Cancers.

[11]  C. Klein,et al.  Tumor Cell Invasion in Glioblastoma , 2020, International journal of molecular sciences.

[12]  S. Stylli,et al.  Extracellular vesicles and their role in glioblastoma , 2019, Critical reviews in clinical laboratory sciences.

[13]  Yoshimasa Tanaka,et al.  Exosomal Thrombospondin-1 Disrupts the Integrity of Endothelial Intercellular Junctions to Facilitate Breast Cancer Cell Metastasis , 2019, Cancers.

[14]  J. Murphy-Ullrich.  Thrombospondin 1 and Its Diverse Roles as a Regulator of Extracellular Matrix in Fibrotic Disease , 2019, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[15]  F. Falciani,et al.  Deciphering the complex role of thrombospondin-1 in glioblastoma development , 2019, Nature Communications.

[16]  Jin Yang,et al.  Myosin Heavy Chain 9: Oncogene or Tumor Suppressor Gene? , 2019, Medical science monitor : international medical journal of experimental and clinical research.

[17]  S. Stylli,et al.  Cell quiescence correlates with enhanced glioblastoma cell invasion and cytotoxic resistance , 2019, Experimental cell research.

[18]  S. Stylli,et al.  Inhibition of Radiation and Temozolomide-Induced Invadopodia Activity in Glioma Cells Using FDA-Approved Drugs , 2018, Translational oncology.

[19]  T. Wurdinger,et al.  An Experimenter's Guide to Glioblastoma Invasion Pathways. , 2018, Trends in molecular medicine.

[20]  J. Barnholtz-Sloan,et al.  Adult Glioma Incidence and Survival by Race or Ethnicity in the United States From 2000 to 2014 , 2018, JAMA oncology.

[21]  M. MacManus,et al.  Radiation therapy-induced metastasis: radiobiology and clinical implications , 2017, Clinical & Experimental Metastasis.

[22]  C. Kang,et al.  Effects of combined radiosurgery and temozolomide therapy on epidermal growth factor receptor and variant III in glioblastoma multiforme , 2018, Oncology letters.

[23]  S. Stylli,et al.  Enhancement of invadopodia activity in glioma cells by sublethal doses of irradiation and temozolomide. , 2017, Journal of neurosurgery.

[24]  H. Shu,et al.  EGF stimulates glioblastoma metastasis by induction of matrix metalloproteinase-9 in an EGFR-dependent mechanism , 2017, Oncotarget.

[25]  Xianglin Yuan,et al.  Thrombospondin-1 is a multifaceted player in tumor progression. , 2017, Oncotarget.

[26]  Jun Wang,et al.  Thrombospondin-1 promotes cell migration, invasion and lung metastasis of osteosarcoma through FAK dependent pathway , 2017, Oncotarget.

[27]  B. Kristensen,et al.  Expression and prognostic impact of matrix metalloproteinase-2 (MMP-2) in astrocytomas , 2017, PloS one.

[28]  V. Préat,et al.  On glioblastoma and the search for a cure: where do we stand? , 2017, Cellular and Molecular Life Sciences.

[29]  Y. Miki,et al.  THBS1 is induced by TGFB1 in the cancer stroma and promotes invasion of oral squamous cell carcinoma. , 2016, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[30]  C. Schneider,et al.  Original insights on thrombospondin-1-related antireceptor strategies in cancer , 2015, Front. Pharmacol..

[31]  W. McBride,et al.  Opportunities and challenges of radiotherapy for treating cancer , 2015, Nature Reviews Clinical Oncology.

[32]  Shin Jung,et al.  Sublethal dose of irradiation enhances invasion of malignant glioma cells through p53-MMP 2 pathway in U87MG mouse brain tumor model , 2015, Radiation oncology.

[33]  V. Cardile,et al.  Characterization of matrix metalloproteinase-2 and -9, ADAM-10 and N-cadherin expression in human glioblastoma multiforme , 2015, Cell and Tissue Research.

[34]  R. Prekeris,et al.  The regulation of MMP targeting to invadopodia during cancer metastasis , 2015, Front. Cell Dev. Biol..

[35]  G. von Heijne,et al.  Tissue-based map of the human proteome , 2015, Science.

[36]  J. Lawler,et al.  Thrombospondin-1 Modulates Actin Filament Remodeling and Cell Motility in Mouse Mammary Tumor cells in Vitro , 2014, Discoveries.

[37]  G. Taraboletti,et al.  Current understanding of the thrombospondin-1 interactome. , 2014, Matrix biology : journal of the International Society for Matrix Biology.

[38]  S. McKeown,et al.  Thrombospondin 1 promotes an aggressive phenotype through epithelial-to-mesenchymal transition in human melanoma , 2014, Oncotarget.

[39]  Stephen L. Brown,et al.  Subcurative radiation significantly increases cell proliferation, invasion, and migration of primary glioblastoma multiforme in vivo , 2014, Chinese journal of cancer.

[40]  Steven J. M. Jones,et al.  Mutational Analysis Reveals the Origin and Therapy-Driven Evolution of Recurrent Glioma , 2014, Science.

[41]  N. Frangogiannis,et al.  Thrombospondin-1 Induction in the Diabetic Myocardium Stabilizes the Cardiac Matrix in Addition to Promoting Vascular Rarefaction Through Angiopoietin-2 Upregulation , 2013, Circulation research.

[42]  G. Opdenakker,et al.  Zymography methods for visualizing hydrolytic enzymes , 2013, Nature Methods.

[43]  D. Hanahan,et al.  Hallmarks of Cancer: The Next Generation , 2011, Cell.

[44]  D. Roberts,et al.  THBS1 (thrombospondin-1). , 2011, Atlas of genetics and cytogenetics in oncology and haematology.

[45]  M. Iruela-Arispe.  Regulation of thrombospondin1 by extracellular proteases. , 2008, Current drug targets.

[46]  S. Stylli,et al.  Invadopodia: At the cutting edge of tumour invasion , 2008, Journal of Clinical Neuroscience.

[47]  D. Strickland,et al.  LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studies. , 2008, Physiological reviews.

[48]  H. Schild,et al.  Pro-invasive gene regulating effect of irradiation and combined temozolomide-radiation treatment on surviving human malignant glioma cells. , 2006, European journal of pharmacology.

[49]  H. Naganuma,et al.  Quantification of thrombospondin-1 secretion and expression of αvβ3 and α3β1 integrins and syndecan-1 as cell-surface receptors for thrombospondin-1 in malignant glioma cells , 2004, Journal of Neuro-Oncology.

[50]  B. Banas,et al.  Identification of Novel β1 Integrin Binding Sites in the Type 1 and Type 2 Repeats of Thrombospondin-1* , 2004, Journal of Biological Chemistry.

[51]  R. Stupp,et al.  Plasma and Cerebrospinal Fluid Population Pharmacokinetics of Temozolomide in Malignant Glioma Patients , 2004, Clinical Cancer Research.

[52]  H. Naganuma,et al.  Antisense‐mediated reduction in thrombospondin‐1 expression reduces cell motility in malignant glioma cells , 2001, International journal of cancer.

[53]  T. Liu,et al.  Suppression of matrix metalloproteinase-2 gene expression and invasion in human glioma cells by MMAC/PTEN , 2001, Oncogene.

[54]  A Rimner,et al.  Sublethal irradiation promotes migration and invasiveness of glioma cells: implications for radiotherapy of human glioblastoma. , 2001, Cancer research.

[55]  A. Orr,et al.  Thrombospondin Mediates Focal Adhesion Disassembly through Interactions with Cell Surface Calreticulin* , 2000, The Journal of Biological Chemistry.

[56]  M. Simons,et al.  Thrombospondin Type 1 Repeats Interact with Matrix Metalloproteinase 2 , 2000, The Journal of Biological Chemistry.

[57]  Preety Choudhary,et al.  Zymography and Reverse Zymography for Testing Proteases and Their Inhibitors. , 2022, Methods in molecular biology.

[58]  J. Barnholtz-Sloan,et al.  CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2012-2016. , 2019, Neuro-oncology.

[59]  K. Debatin,et al.  Radiation and Brain Tumors: An Overview. , 2018, Critical reviews in oncogenesis.

[60]  H. Horiguchi,et al.  Thrombospondin-1 is highly expressed in desmoplastic components of invasive ductal carcinoma of the breast and associated with lymph node metastasis. , 2013, The journal of medical investigation : JMI.

[61]  J. Lawler,et al.  Thrombospondins in cancer. , 2008, Cellular and molecular life sciences : CMLS.

[62]  G. Tuszynski,et al.  Up-regulation of matrix metalloproteinase 9 by thrombospondin 1 in gastric cancer. , 2002, The Journal of surgical research.

[63]  P. Majerus,et al.  A thrombin-sensitive protein of human platelet membranes. , 1971, Proceedings of the National Academy of Sciences of the United States of America.