Relationship between the formation of promutagenic adducts and the activation of the K-ras protooncogene in lung tumors from A/J mice treated with nitrosamines.

[1]  Marshall W. Anderson,et al.  Activation of the Ki-ras protooncogene in spontaneously occurring and chemically induced lung tumors of the strain A mouse. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[2]  K. Tindall,et al.  Molecular analysis of spontaneous mutations at the gpt locus in Chinese hamster ovary (AS52) cells. , 1989, Mutation research.

[3]  T. Skopek,et al.  Formation of O6-methyldeoxyguanosine at specific sites in a synthetic oligonucleotide designed to resemble a known mutagenic hotspot. , 1989, Journal of Biological Chemistry.

[4]  S. Amin,et al.  Induction of lung and exocrine pancreas tumors in F344 rats by tobacco-specific and Areca-derived N-nitrosamines. , 1988, Cancer research.

[5]  M. Dolan,et al.  Sequence specificity of guanine alkylation and repair. , 1988, Carcinogenesis.

[6]  M. Dolan,et al.  Cell specific differences in O6-methylguanine-DNA methyltransferase activity and removal of O6-methylguanine in rat pulmonary cells. , 1988, Carcinogenesis.

[7]  S. Rodenhuis,et al.  Incidence and possible clinical significance of K-ras oncogene activation in adenocarcinoma of the human lung. , 1988, Cancer research.

[8]  Y. Nakamura,et al.  Genetic alterations during colorectal-tumor development. , 1988, The New England journal of medicine.

[9]  B W Glickman,et al.  Influence of neighboring base sequence on the distribution and repair of N-ethyl-N-nitrosourea-induced lesions in Escherichia coli. , 1988, Cancer research.

[10]  S. Belinsky,et al.  Factors regulating activation and DNA alkylation by 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone and nitrosodimethylamine in rat lung and isolated lung cells, and the relationship to carcinogenicity. , 1988, Cancer research.

[11]  K. Mullis,et al.  Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. , 1988, Science.

[12]  P C Hanawalt,et al.  Heterogeneous DNA damage and repair in the mammalian genome. , 1987, Cancer research.

[13]  R R Maronpot,et al.  Activated oncogenes in B6C3F1 mouse liver tumors: implications for risk assessment. , 1987, Science.

[14]  R. Maronpot,et al.  Activation of the K-ras protooncogene in lung tumors from rats and mice chronically exposed to tetranitromethane. , 1987, Cancer research.

[15]  R. Tennant,et al.  Prediction of chemical carcinogenicity in rodents from in vitro genetic toxicity assays. , 1987, Science.

[16]  V. Stanton,et al.  Activation of human raf transforming genes by deletion of normal amino-terminal coding sequences , 1987, Molecular and cellular biology.

[17]  S. Belinsky,et al.  Cell selective alkylation of DNA in rat lung following low dose exposure to the tobacco specific carcinogen 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone. , 1987, Cancer research.

[18]  J. Miller,et al.  Activating mutations of the c-Ha-ras protooncogene in chemically induced hepatomas of the male B6C3 F1 mouse. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[19]  S. Belinsky,et al.  Accumulation and persistence of DNA adducts in respiratory tissue of rats following multiple administrations of the tobacco specific carcinogen 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone. , 1986, Cancer research.

[20]  P. Kollman,et al.  The effect of methylation of the 6 oxygen of guanine on the structure and stability of double helical DNA. , 1985, Journal of biomolecular structure & dynamics.

[21]  C. Marshall,et al.  Amino-acid substitutions at codon 13 of the N-ras oncogene in human acute myeloid leukaemia , 1985, Nature.

[22]  J. Swenberg,et al.  Differential repair of O4-alkylthymidine following exposure to methylating and ethylating hepatocarcinogens. , 1985, Carcinogenesis.

[23]  J. Bos,et al.  Three different mutations in codon 61 of the human N-ras gene detected by synthetic oligonucleotide hybridization. , 1984, Nucleic acids research.

[24]  M. Wigler,et al.  Analysis of the transforming potential of the human H-ras gene by random mutagenesis. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[25]  M. D. Topal,et al.  Mechanism of mutagenesis by O6-methylguanine , 1984, Nature.

[26]  M. Barbacid,et al.  Induction of mammary carcinomas in rats by nitroso-methylurea involves malignant activation of H-ras-1 locus by single point mutations , 1983, Nature.

[27]  S. Hecht,et al.  Induction of respiratory tract tumors in Syrian golden hamsters by a single dose of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and the effect of smoke inhalation. , 1983, Carcinogenesis.

[28]  J. Hall,et al.  The incorporation of O6-methyldeoxyguanosine and O4-methyldeoxythymidine monophosphates into DNA by DNA polymerases I and alpha. , 1983, Nucleic acids research.

[29]  S. Hecht,et al.  Comparative carcinogenicity in A/J mice and metabolism by cultured mouse peripheral lung of N'-nitrosonornicotine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, and their analogues. , 1983, Cancer research.

[30]  M. Gonda,et al.  The p21 src genes of Harvey and Kirsten sarcoma viruses originate from divergent members of a family of normal vertebrate genes , 1981, Nature.

[31]  S. Kauffman.  Histogenesis of the papillary Clara cell adenoma. , 1981, The American journal of pathology.

[32]  S. Hecht,et al.  Metabolism in the F344 rat of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco-specific carcinogen. , 1980, Cancer research.

[33]  S. Hecht,et al.  A STUDY OF CHEMICAL CARCINOGENESIS. 14. HYDROLYSIS OF MODEL COMPOUNDS FOR α-HYDROXYLATION OF THE CARCINOGENS N-NITROSOPYRROLIDINE AND N′-NITROSONORNICOTINE , 1979 .

[34]  S. Hecht,et al.  Assessment of tobacco-specific N-nitrosamines in tobacco products. , 1979, Cancer research.

[35]  S. Kauffman,et al.  Histologic and ultrastructural features of the clara cell adenoma of the mouse lung. , 1979, Laboratory investigation; a journal of technical methods and pathology.

[36]  R. Saffhill,et al.  DNA synthesis with methylated poly(dC-dG) templates. Evidence for a competitive nature to miscoding by O(6)-methylguanine. , 1979, Biochimica et biophysica acta.

[37]  E. Southern.  Detection of specific sequences among DNA fragments separated by gel electrophoresis. , 1975, Journal of molecular biology.

[38]  J. Marmur.  A procedure for the isolation of deoxyribonucleic acid from micro-organisms , 1961 .

[39]  S. Hecht,et al.  Evidence for 4-(3-pyridyl)-4-oxobutylation of DNA in F344 rats treated with the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N'-nitrosonornicotine. , 1988, Carcinogenesis.

[40]  T R Skopek,et al.  DNA base changes and alkylation following in vivo exposure of Escherichia coli to N-methyl-N-nitrosourea or N-ethyl-N-nitrosourea. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[41]  R. Maronpot,et al.  Detection and identification of activated oncogenes in spontaneously occurring benign and malignant hepatocellular tumors of the B6C3F1 mouse. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[42]  M. Barbacid,et al.  Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats , 1985, Nature.

[43]  R. B. Wallace,et al.  Allele-Specific Hybridization Using Oligonucleotide Probes of Very High Specific Activity: Discrimination of the Human βA- and βS-Globin Genes , 1984 .

[44]  S. Hecht,et al.  Effects of alpha-deuterium substitution on the mutagenicity of 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK). , 1983, Carcinogenesis.

[45]  K. Itakura,et al.  Detection of sickle cell beta S-globin allele by hybridization with synthetic oligonucleotides. , 1983, Proceedings of the National Academy of Sciences of the United States of America.