Reversal of acetaminophen toxicity in isolated hamster hepatocytes by dithiothreitol.

[1]  S. Thorgeirsson,et al.  Acetaminophen-induced hepatic necrosis. VI. Metabolic disposition of toxic and nontoxic doses of acetaminophen. , 1974, Pharmacology.

[2]  S. Orrenius,et al.  The role of lipid peroxidation in the toxicity of foreign compounds to liver cells. , 1983, Biochemical pharmacology.

[3]  A. Boobis,et al.  Paracetamol oxidation: synthesis and reactivity of N-acetyl-p-benzoquinoneimine , 1981 .

[4]  J. Villeneuve,et al.  EFFECT OF N-ACETYLCYSTEINE ON HEPATIC COVALENT BINDING OF PARACETAMOL (ACETAMINOPHEN) , 1977, The Lancet.

[5]  S. Orrenius,et al.  Inhibition of ATP-dependent microsomal Ca2+ sequestration during oxidative stress and its prevention by glutathione. , 1983, The Journal of biological chemistry.

[6]  S. Orrenius,et al.  Regulation of intracellular calcium compartmentation: studies with isolated hepatocytes and t-butyl hydroperoxide. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[7]  A. Y. Lu,et al.  N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[8]  W. J. Racz,et al.  Scanning electron microscopic examination of acetaminophen-induced hepatotoxicity and congestion in mice. , 1983, The American journal of pathology.

[9]  B B Brodie,et al.  Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism. , 1973, The Journal of pharmacology and experimental therapeutics.

[10]  L. J. Fischer,et al.  Hamster hepatocytes in culture as a model for acetaminophen toxicity studies with inhibitors of drug metabolism. , 1983, Toxicology and applied pharmacology.

[11]  J. Miners,et al.  Mechanism of action of paracetamol protective agents in mice in vivo. , 1984, Biochemical pharmacology.

[12]  P. Seglen.  Preparation of rat liver cells. 3. Enzymatic requirements for tissue dispersion. , 1973, Experimental cell research.

[13]  C. Tyson,et al.  Metabolism and cytotoxicity of acetaminophen in hepatocytes isolated from resistant and susceptible species. , 1984, Toxicology and applied pharmacology.

[14]  B B Brodie,et al.  Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo. , 1973, The Journal of pharmacology and experimental therapeutics.

[15]  A Wendel,et al.  Acute paracetamol intoxication of starved mice leads to lipid peroxidation in vivo. , 1979, Biochemical pharmacology.

[16]  S. Orrenius,et al.  Critical role of sulfhydryl group(s) in ATP‐dependent Ca2+ sequestration by the plasma membrane fraction from rat liver , 1983, FEBS letters.

[17]  S. Orrenius,et al.  Increase in cytosolic Ca2+ concentration during t‐butyl hydroperoxide metabolism by isolated hepatocytes involves NADPH oxidation and mobilization of intracellular Ca2+ stores , 1984, FEBS letters.

[18]  D M Bissell,et al.  Drug metabolism in adult rat hepatocytes in primary monolayer culture. , 1977, Gastroenterology.

[19]  J R Gillette,et al.  Acetaminophen-induced hepatotoxicity. , 1981, Life sciences.

[20]  P. McCay,et al.  Evidence that peroxidation of lysosomal membranes is initiated by hydroxyl free radicals produced during flavin enzyme activity. , 1973, The Journal of biological chemistry.

[21]  J. Mitchell,et al.  Evidence for redox cycling of acetaminophen and its reactive metabolite by endogenous microsomal systems. , 1981, Advances in experimental medicine and biology.

[22]  O. H. Lowry,et al.  Protein measurement with the Folin phenol reagent. , 1951, The Journal of biological chemistry.

[23]  A. Ottolenghi.  Interaction of ascorbic acid and mitochondrial lipides , 1959 .

[24]  S. Orrenius,et al.  Bleb formation in hepatocytes during drug metabolism is caused by disturbances in thiol and calcium ion homeostasis. , 1982, Science.

[25]  A. Mclean,et al.  Dissociation of cell death from covalent binding of paracetamol by flavones in a hepatocyte system. , 1982, Biochemical pharmacology.

[26]  S. Thorgeirsson,et al.  Acetaminophen-induced hepatic necrosis. V. Correlation of hepatic necrosis, covalent binding and glutathione depletion in hamsters. , 1974, Pharmacology.

[27]  F. Tietze.  Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. , 1969, Analytical biochemistry.

[28]  S. Orrenius,et al.  The toxicity of acetaminophen and N-acetyl-p-benzoquinone imine in isolated hepatocytes is associated with thiol depletion and increased cytosolic Ca2+. , 1985, The Journal of biological chemistry.

[29]  J. Mitchell,et al.  Mechanism of action of N-acetylcysteine in the protection against the hepatotoxicity of acetaminophen in rats in vivo. , 1983, The Journal of clinical investigation.

[30]  M. Kaliner,et al.  Cyclic nucleotides and modulation of effector systems of inflammation. , 1974, Biochemical pharmacology.

[31]  A Casini,et al.  Mechanisms of cell injury in the killing of cultured hepatocytes by bromobenzene. , 1982, The Journal of biological chemistry.

[32]  L. Prescott.  Glutathione: a protective mechanism against hepatotoxicity. , 1982, Biochemical Society transactions.

[33]  B B Brodie,et al.  Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione. , 1973, The Journal of pharmacology and experimental therapeutics.

[34]  D. Davidson,et al.  Acute liver necrosis following overdose of paracetamol. , 1966, British medical journal.

[35]  S. Orrenius,et al.  Potentiation of oxidative cell injury in hepatocytes which have accumulated Ca2+. , 1984, The Journal of biological chemistry.

[36]  D. Miner,et al.  Evidence for the involvement of N-acetyl-p- quinoneimine in acetaminophen metabolism. , 1979, Biochemical pharmacology.

[37]  S. Orrenius,et al.  The measurement of lipid peroxidation in isolated hepatocytes. , 1982, Biochemical pharmacology.