Intestinal Microbiota-Kidney Cross Talk in Acute Kidney Injury and Chronic Kidney Disease

The pathophysiology of acute kidney injury (AKI) involves multiple and overlapping immunological, biochemical, and hemodynamic mechanisms that modulate the effects of both the initial insult and the subsequent repair. Limited but recent experimental data have revealed that the intestinal microbiota significantly affects outcomes in AKI. Additional evidence shows significant changes in the intestinal microbiota in chronic kidney disease patients and in experimental AKI. In this minireview, we discuss the current status of the effect of intestinal microbiota on kidney diseases, the immunomodulatory effects of intestinal microbiota, and the potential mechanisms by which microbiota can modify kidney diseases and vice versa. We also propose future studies to clarify the role of intestinal microbiota in kidney diseases and to explore how the modification of gut microbiota may be a potential therapeutic tool.

[1]  J. Kellum,et al.  Acute kidney injury. , 2021, BMJ clinical evidence.

[2]  D. Raj,et al.  The gut microbiome, kidney disease, and targeted interventions. , 2014, Journal of the American Society of Nephrology : JASN.

[3]  W. F. Fricke,et al.  Human Microbiota Characterization in the Course of Renal Transplantation , 2014, American Journal of Transplantation.

[4]  D. Fouque,et al.  Protein-bound uremic toxins…new targets to prevent insulin resistance and dysmetabolism in patients with chronic kidney disease. , 2013, Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation.

[5]  D. Fouque,et al.  Dietary protein metabolism by gut microbiota and its consequences for chronic kidney disease patients. , 2013, Future microbiology.

[6]  F. Verbrugge,et al.  Abdominal contributions to cardiorenal dysfunction in congestive heart failure. , 2013, Journal of the American College of Cardiology.

[7]  B. Stecher,et al.  The intestinal microbiota, a leaky gut, and abnormal immunity in kidney disease. , 2013, Kidney international.

[8]  B. Meijers,et al.  The Colon: An Overlooked Site for Therapeutics in Dialysis Patients , 2013, Seminars in dialysis.

[9]  J. Gordon,et al.  Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation , 2013, Proceedings of the National Academy of Sciences.

[10]  G. Andersen,et al.  Chronic kidney disease alters intestinal microbial flora. , 2013, Kidney international.

[11]  Hongli Jiang,et al.  Gut bacterial translocation is associated with microinflammation in end‐stage renal disease patients , 2012, Nephrology.

[12]  N. Vaziri.  CKD impairs barrier function and alters microbial flora of the intestine: a major link to inflammation and uremic toxicity , 2012, Current opinion in nephrology and hypertension.

[13]  Casey T. Weaver,et al.  Reciprocal interactions of the intestinal microbiota and immune system , 2012, Nature.

[14]  S. Mazmanian,et al.  Intestinal microbes affect phenotypes and functions of invariant natural killer T cells in mice. , 2012, Gastroenterology.

[15]  S. Mazmanian,et al.  Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis , 2010, Proceedings of the National Academy of Sciences.

[16]  P. Bork,et al.  A human gut microbial gene catalogue established by metagenomic sequencing , 2010, Nature.

[17]  M. Rosner,et al.  Acute kidney injury. , 2009, Current drug targets.

[18]  H. Rabb,et al.  Early exposure to germs modifies kidney damage and inflammation after experimental ischemia-reperfusion injury. , 2009, American journal of physiology. Renal physiology.

[19]  Annaïg Lan,et al.  The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses. , 2009, Immunity.

[20]  M. Hattori,et al.  Cd1d-dependent regulation of bacterial colonization in the intestine of mice. , 2009, The Journal of clinical investigation.

[21]  W. Verstraete,et al.  In Vitro and In Vivo Assessment of Intraintestinal Bacteriotherapy in Chronic Kidney Disease , 2006, ASAIO journal.

[22]  A. Macpherson,et al.  Interactions between commensal intestinal bacteria and the immune system , 2004, Nature Reviews Immunology.

[23]  C. Karp,et al.  The germless theory of allergic disease: revisiting the hygiene hypothesis , 2001, Nature Reviews Immunology.

[24]  P. Li,et al.  Circulating endotoxemia: a novel factor in systemic inflammation and cardiovascular disease in chronic kidney disease. , 2011, Clinical journal of the American Society of Nephrology : CJASN.