A pediatric case with vasculitis‐like viral eruption induced by Epstein–Barr virus

four Chinese individuals and six Malaysians have been reported to harbor the same mutation. Thus, the mutation appears to be relatively common in Asians. The second case discussed here showed juvenile-onset GPP. After considering the high incidence of such cases, we can hypothesize that this splice-site mutation may result in early-onset GPP. In conclusion, herein we report T123M and 115+6T>C mutations, both homozygous in nature, in two Japanese individuals with Zumbusch type of GPP. Recently, the mutations of the IL36RN gene were shown to be associated with palmoplantar pustulosis, acrodermatitis continua of Hallopeau, and acute generalized exanthematous pustulosis. Mutation analysis for GPP and these related pustular disorders have been instrumental in the development of specific treatment armamentarium for IL36 signaling.