Is Renal Function Associated with Early Age-Related Macular Degeneration?

Purpose Age-related macular degeneration (AMD) and chronic kidney disease both involve immune dysregulation and may share underlying pathophysiologic changes to systemic homeostasis. Hence, we aim to evaluate associations between impaired kidney function and early AMD, in a search for urinary biomarkers for AMD. Methods A population-based, cross-sectional analysis of persons aged 45 to 84 years was conducted with renal function measured using serum creatinine and cystatin C levels and the estimated glomerular filtration rate (eGFR) calculated. Age-related macular degeneration status was ascertained from retinal photographs. Results Of 5874 participants, 221 had early AMD. High serum cystatin C and low eGFR (⩽60 ml/min/1.73 m2) were not associated with early AMD in our multivariate analyses. Among normotensive persons, however, highest versus other deciles of cystatin C were associated with an increased prevalence of early AMD (odds ratio, 1.80; 95% confidence interval, 1.00 to 3.23). Conclusions Results could not confirm an association between kidney function and early AMD. The borderline association between cystatin C and early AMD in normotensive persons require further verification.

[1]  Josef Coresh,et al.  Cystatin C versus creatinine in determining risk based on kidney function. , 2013, The New England journal of medicine.

[2]  Harold I Feldman,et al.  Estimating glomerular filtration rate from serum creatinine and cystatin C. , 2012, The New England journal of medicine.

[3]  Josef Coresh,et al.  Chronic kidney disease , 2012, The Lancet.

[4]  J. Moon,et al.  Chronic Kidney Disease, Early Age-related Macular Degeneration, and Peripheral Retinal Drusen , 2011, Ophthalmic epidemiology.

[5]  Robyn H Guymer,et al.  Identification of urinary biomarkers for age-related macular degeneration. , 2011, Investigative ophthalmology & visual science.

[6]  R. Klein,et al.  Prevalence of age-related macular degeneration in old persons: Age, Gene/environment Susceptibility Reykjavik Study. , 2011, Ophthalmology.

[7]  R. Klein,et al.  Serum cystatin C level, kidney disease markers, and incidence of age-related macular degeneration: the Beaver Dam Eye Study. , 2009, Archives of ophthalmology.

[8]  L. Smeeth,et al.  Associations Between Chronic Kidney Disease and Age-Related Macular Degeneration , 2009, Ophthalmic epidemiology.

[9]  P. Mitchell,et al.  CKD increases the risk of age-related macular degeneration. , 2008, Journal of the American Society of Nephrology : JASN.

[10]  J. J. Wang,et al.  Complement factor H polymorphisms, renal phenotypes and age-related macular degeneration: the Blue Mountains Eye Study , 2008, Genes and Immunity.

[11]  R. Klein,et al.  Complement factor H and hemicentin-1 in age-related macular degeneration and renal phenotypes. , 2007, Human molecular genetics.

[12]  上村 治.  知っておきたい用語の解説 Chronic Kidney Disease(CKD) , 2007 .

[13]  P. Mitchell,et al.  Cardiovascular risk factors and the long-term incidence of age-related macular degeneration: the Blue Mountains Eye Study. , 2007, Ophthalmology.

[14]  E. Im,et al.  The role of cathepsins in ocular physiology and pathology. , 2007, Experimental eye research.

[15]  M. Shlipak.  Cystatin C as a marker of glomerular filtration rate in chronic kidney disease: influence of body composition , 2007, Nature Clinical Practice Nephrology.

[16]  B. Kestenbaum,et al.  Cystatin C and Prognosis for Cardiovascular and Kidney Outcomes in Elderly Persons without Chronic Kidney Disease , 2006, Annals of Internal Medicine.

[17]  R. Klein,et al.  Prevalence of age-related macular degeneration in 4 racial/ethnic groups in the multi-ethnic study of atherosclerosis. , 2006, Ophthalmology.

[18]  A. Christensson,et al.  Simple cystatin C-based prediction equations for glomerular filtration rate compared with the modification of diet in renal disease prediction equation for adults and the Schwartz and the Counahan-Barratt prediction equations for children. , 2005, Clinical chemistry.

[19]  T. Mathew.  Chronic kidney disease and automatic reporting of estimated glomerular filtration rate: a position statement , 2005, The Medical journal of Australia.

[20]  R. T. Smith,et al.  A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[21]  E. Im,et al.  Cathepsin B regulates the intrinsic angiogenic threshold of endothelial cells. , 2005, Molecular biology of the cell.

[22]  A. Edwards,et al.  Complement Factor H Polymorphism and Age-Related Macular Degeneration , 2005, Science.

[23]  J. Gilbert,et al.  Complement Factor H Variant Increases the Risk of Age-Related Macular Degeneration , 2005, Science.

[24]  L. Fried,et al.  Cystatin C Concentration as a Risk Factor for Heart Failure in Older Adults , 2005, Annals of Internal Medicine.

[25]  T. Greene,et al.  Performance of the modification of diet in renal disease and Cockcroft-Gault equations in the estimation of GFR in health and in chronic kidney disease. , 2005, Journal of the American Society of Nephrology : JASN.

[26]  R. Klein,et al.  Detection of age-related macular degeneration using a nonmydriatic digital camera and a standard film fundus camera. , 2004, Archives of ophthalmology.

[27]  B. Munoz,et al.  Racial variations in causes of vision loss in nursing homes: The Salisbury Eye Evaluation in Nursing Home Groups (SEEING) Study. , 2004, Archives of ophthalmology.

[28]  J. H. Jansen,et al.  The molecular basis for hereditary porcine membranoproliferative glomerulonephritis type II: point mutations in the factor H coding sequence block protein secretion. , 2002, The American journal of pathology.

[29]  R. Kronmal,et al.  Multi-Ethnic Study of Atherosclerosis: objectives and design. , 2002, American journal of epidemiology.

[30]  V. Dharnidharka,et al.  Serum cystatin C is superior to serum creatinine as a marker of kidney function: a meta-analysis. , 2002, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[31]  P. Raskin,et al.  Report of the expert committee on the diagnosis and classification of diabetes mellitus. , 1999, Diabetes care.

[32]  P. Mitchell,et al.  Visual acuity and the causes of visual loss in Australia. The Blue Mountains Eye Study. , 1996, Ophthalmology.

[33]  R. Klein,et al.  Prevalence of age-related maculopathy. The Beaver Dam Eye Study. , 1992, Ophthalmology.

[34]  R. Gokal,et al.  Fundus changes in mesangiocapillary glomerulonephritis type II: clinical and fluorescein angiographic findings. , 1989, The British journal of ophthalmology.

[35]  N. McKechnie,et al.  Fundus changes in (type II) mesangiocapillary glomerulonephritis simulating drusen: a histopathological report. , 1989, The British journal of ophthalmology.

[36]  R. Sperduto,et al.  Systemic hypertension and age-related maculopathy in the Framingham Study. , 1986, Archives of ophthalmology.

[37]  G. Filler,et al.  Cystatin C as a marker of GFR--history, indications, and future research. , 2005, Clinical biochemistry.

[38]  Benita J. O’Colmain,et al.  Prevalence of age-related macular degeneration in the United States. , 2004, Archives of ophthalmology.

[39]  A. Barrett.  The cystatins: a diverse superfamily of cysteine peptidase inhibitors. , 1986, Biomedica biochimica acta.