Systematic review and meta-analysis of skeletal muscle fatigue in old age.

UNLABELLED Despite intense interest in understanding how old age may alter skeletal muscle fatigability, a quantitative examination of the impact of study design on age-related differences in muscle fatigue does not exist. PURPOSE The purpose of this study was to conduct a systematic review of the differences in muscle fatigue between young and older adults, with specific examination of moderator variables suggested to contribute to discrepancies across studies: contraction intensity, contraction mode, duty cycle, fatigue index, sex, muscle group, and contraction type. METHODS The standardized effect of age on muscle fatigue was computed for 37 studies (60 standardized effects). Standardized effects were coded as positive when less fatigue was reported in older individuals compared with young individuals. RESULTS The overall standardized effect of age on muscle fatigue was positive (0.56). In studies using dynamic contractions or using muscle power as the index of fatigue, the standardized effect was negative (-0.12 and -2.5, respectively). The standardized effect for all other moderator categories was positive (range = 0.09-0.90), indicating less fatigue in older adults under all other methodological conditions. CONCLUSION This review provides the first quantitative analysis of the effect of study design on age-related differences in muscle fatigue. The results indicate that older individuals develop less muscle fatigue than young individuals, particularly during isometric contractions of the elbow flexor and knee extensor muscles. However, the results also suggest that older adults develop greater fatigue during dynamic contractions, particularly when the decline in power is assessed. Studies that verify this latter outcome are needed, as are studies designed to elucidate the mechanisms of fatigue.

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