Spontaneous rodent models of diabetes and diabetic retinopathy.

Diabetes is a complex and heterogeneous disorder presently affecting more than 100 million people worldwide and causing serious socio-economic problems. Spontaneous rodent models of diabetes mellitus have proved invaluable in understanding the pathogenesis, complications, and genetic or environmental influences that increase the risks of diabetes. We have reviewed here in the development and characterization of spontaneous rodent models that displayed most features commonly associated with diabetic retinopathy.

[1]  E. Rakoczy,et al.  VEGF-induced choroidal damage in a murine model of retinal neovascularisation , 2008, British Journal of Ophthalmology.

[2]  A. Sima,et al.  Alzheimer-Like Changes in Rat Models of Spontaneous Diabetes , 2007, Diabetes.

[3]  Dong Ho Jung,et al.  Effects of KIOM-79 on hyperglycemia and diabetic nephropathy in type 2 diabetic Goto-Kakizaki rats. , 2007, Journal of ethnopharmacology.

[4]  D. Ziegler.  Treatment of Diabetic Polyneuropathy , 2006, Annals of the New York Academy of Sciences.

[5]  A. Barber,et al.  Loss of cholinergic and dopaminergic amacrine cells in streptozotocin-diabetic rat and Ins2Akita-diabetic mouse retinas. , 2006, Investigative ophthalmology & visual science.

[6]  Ping Wang,et al.  [The expression of HIF-1 in the early diabetic NOD mice]. , 2006, Yan ke xue bao = Eye science.

[7]  H. Sone,et al.  Antioxidants and an inhibitor of advanced glycation ameliorate death of retinal microvascular cells in diabetic retinopathy , 2006, Diabetes/metabolism research and reviews.

[8]  T. Gardner,et al.  The Ins2Akita mouse as a model of early retinal complications in diabetes. , 2005, Investigative ophthalmology & visual science.

[9]  J. Alcolado,et al.  Animal models of diabetes mellitus , 2005, Diabetic medicine : a journal of the British Diabetic Association.

[10]  Claude Messier,et al.  Longitudinal evaluation of memory performance and peripheral neuropathy in the Ins2C96Y Akita mice , 2005, Behavioural Brain Research.

[11]  S. Ueda,et al.  Otsuka Long-Evans Tokushima fatty (OLETF) rat is not a suitable animal model for the study of angiopathic diabetic retinopathy. , 2005, International journal of tissue reactions.

[12]  M. Nóbrega,et al.  Initial characterization of a rat model of diabetic nephropathy. , 2004, Diabetes.

[13]  R. Iezzi,et al.  Temporal variation in diabetic macular edema measured by optical coherence tomography. , 2004, Ophthalmology.

[14]  D. Greiner,et al.  Rat models of type 1 diabetes: genetics, environment, and autoimmunity. , 2004, ILAR journal.

[15]  John C Rutledge,et al.  The challenge of type 1 diabetes mellitus. , 2004, ILAR journal.

[16]  T. Moran,et al.  Response to acute food deprivation in OLETF rats lacking CCK-A receptors , 2003, Physiology & Behavior.

[17]  H. Kurumatani,et al.  Late Onset of Diabetic Nephropathy in Spontaneously Diabetic GK Rats , 2003, American Journal of Nephrology.

[18]  L. M. Aiello,et al.  Perspectives on diabetic retinopathy. , 2003, American journal of ophthalmology.

[19]  T. Amemiya,et al.  Retinal changes in Otsuka long-evans Tokushima Fatty rats (spontaneously diabetic rat)--possibility of a new experimental model for diabetic retinopathy. , 2003, Japanese journal of ophthalmology.

[20]  C. Kurts,et al.  Development of new strategies to prevent type 1 diabetes: the role of animal models , 2003, Annals of medicine.

[21]  M. Cameron,et al.  Cytokines and chemokines in the pathogenesis of murine type 1 diabetes. , 2003, Advances in experimental medicine and biology.

[22]  M. Grant,et al.  Time course of NADH oxidase, inducible nitric oxide synthase and peroxynitrite in diabetic retinopathy in the BBZ/WOR rat. , 2002, Nitric oxide : biology and chemistry.

[23]  T. Moran,et al.  Actions of CCK in the controls of food intake and body weight: Lessons from the CCK-A receptor deficient OLETF rat , 2002, Neuropeptides.

[24]  S. Ramanathan,et al.  BB rat lyp mutation and Type 1 diabetes , 2001, Immunological reviews.

[25]  T. Mandrup-Poulsen,et al.  A choice of death – the signal-transduction of immune-mediated beta-cell apoptosis , 2001, Diabetologia.

[26]  H. Jun,et al.  Cellular and Molecular Pathogenic Mechanisms of Insulin‐Dependent Diabetes Mellitus , 2001, Annals of the New York Academy of Sciences.

[27]  F. Lally,et al.  Apoptosis and disease progression in the spontaneously diabetic BB/S rat , 2001, Diabetologia.

[28]  D. Waite,et al.  Levels of Art2+ Cells but not Soluble Art2 Protein Correlate with Expression of Autoimmune Diabetes in the BB Rat , 2001, Autoimmunity.

[29]  H. Luthman,et al.  Insulin-degrading enzyme identified as a candidate diabetes susceptibility gene in GK rats. , 2000, Human molecular genetics.

[30]  A. Mizuno,et al.  Pathoetiology and prevention of NIDDM lessons from the OLETF rat. , 1999, The journal of medical investigation : JMI.

[31]  T. Amemiya,et al.  Retinal Capillary Changes in Otsuka Long-Evans Tokushima Fatty Rats (Spontaneously Diabetic Strain) , 1999, Ophthalmic Research.

[32]  K. Sugimoto,et al.  Experimental diabetic neuropathy: an update , 1999, Diabetologia.

[33]  R. Sherwin,et al.  Control of Autoimmune Diabetes in NOD Mice by GAD Expression or Suppression in β Cells , 1999 .

[34]  K. Fukumitsu,et al.  Metabolic abnormalities in the genetically obese and diabetic Otsuka Long-Evans Tokushima Fatty rat can be prevented and reversed by alpha-glucosidase inhibitor. , 1999, Metabolism: clinical and experimental.

[35]  J. Cunningham,et al.  Insulitis and mechanisms of disease resistance: studies in an animal model of insulin dependent diabetes mellitus , 1999, Journal of Molecular Medicine.

[36]  E. Agardh,et al.  The glutathione levels are reduced in Goto-Kakizaki rat retina, but are not influenced by aminoguanidine treatment. , 1998, Current eye research.

[37]  H. Suzuki,et al.  Ocular vascular endothelial growth factor levels in diabetic rats are elevated before observable retinal proliferative changes , 1997, Diabetologia.

[38]  P. Saï,et al.  [Spontaneous animal models for insulin-dependent diabetes (type 1 diabetes)]. , 1997, Veterinary Research.

[39]  M. Rowley,et al.  Lack of autoimmune serological reactions in rodent models of insulin dependent diabetes mellitus. , 1996, Journal of autoimmunity.

[40]  J. Rajfer,et al.  Reduction of penile nitric oxide synthase in diabetic BB/WORdp (type I) and BBZ/WORdp (type II) rats with erectile dysfunction. , 1995, Endocrinology.

[41]  J. Todd.  Genetic analysis of type 1 diabetes using whole genome approaches. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[42]  R. Traystman,et al.  Ethical Issues Involved in the Development of Animal Models for Type I Diabetes , 1993 .

[43]  K. Kawano,et al.  Spontaneous Long-Term Hyperglycemic Rat With Diabetic Complications: Otsuka Long-Evans Tokushima Fatty (OLETF) Strain , 1992, Diabetes.

[44]  J. Mordes,et al.  Animal models of diabetes. , 1981, American Journal of Medicine.

[45]  Y. Tochino,et al.  Breeding of a non-obese, diabetic strain of mice. , 1980, Jikken dobutsu. Experimental animals.