Sexually transmitted infections in Spain: Current status

Sexually Transmitted Infections (STI) are a major public health problem. The problems inherent to their diagnosis, treatment and prevention have to do not only with their nature, but also with organizational issues and overlapping competencies of the different health authorities in Spain. The real situation of STI in Spain, at present, is poorly known. For this reason, the Scientific Committee on COVID and Emerging Pathogens of the Illustrious Official College of Physicians of Madrid (ICOMEM) has formulated a series of questions on this subject which were distributed, not only among the members of the Committee, but also among experts outside it. The central health authorities provide very high and increasing figures for gonococcal infection, syphilis, Chlamydia trachomatis infection and lymphogranuloma venereum (LGV). Both HIV infection and Monkeypox are two important STI caused by viruses in our environment, to which it should be added, mainly, Herpes simplex virus (HSV) and Human papillomavirus (HPV) infections. Emerging microorganisms such as Mycoplasma genitalium pose not only pathogenic challenges but also therapeutic problems, as in the case of N. gonohrroeae. The pathways that patients with suspected STI follow until they are adequately diagnosed and treated are not well known in Spain. Experts understand that this problem is fundamentally managed in public health institutions, and that Primary Care and Hospital Emergency Services, together with some institutions that deal monographically with this problem, are the recipients of most of these patients. One of the most serious difficulties of STI lies in the availability of the microbiological tests necessary for their diagnosis, particularly in this era of outsourcing of microbiology services. Added to this is the increased cost of implementing the latest generation of molecular techniques and the difficulties of transporting samples. It is clear that STI are not diseases to which the entire population is equally exposed and it is necessary to have a better knowledge of the risk groups where to focus the necessary interventions adapted to their characteristics. It should not be forgotten that STI are also a problem in the pediatric age group and that their presence can be a marker of sexual abuse with all that this implies in terms of health care and medicolegal activity. Finally, STI are infections that are associated with a high cost of care for which we have very little information. The possibility of expanding the automatic performance of laboratory tests for STI surveillance through laboratory routines is encountering ethical and legal problems that are not always easy to solve. Spain has created a ministerial area of specific attention to STI and there are plans to improve the diagnosis, treatment and prevention of these problems, but we still lack the necessary evidence on their impact. We cannot forget that these are diseases that transcend the individual and constitute a Public Health problem.

[1]  J. Molina,et al.  Interim position statement on doxycycline post-exposure prophylaxis (Doxy-PEP) for the prevention of bacterial sexually transmissible infections in Australia and Aotearoa New Zealand - the Australasian Society for HIV, Viral Hepatitis and Sexual Health Medicine (ASHM). , 2023, Sexual health.

[2]  M. Brekke,et al.  Sexually transmitted infections among patients attending a sexual assault centre: a cohort study from Oslo, Norway , 2022, BMJ Open.

[3]  N. Vale,et al.  Therapeutic Options for Chlamydia trachomatis Infection: Present and Future , 2022, Antibiotics.

[4]  N. Vale,et al.  Chlamydia trachomatis as a Current Health Problem: Challenges and Opportunities , 2022, Diagnostics.

[5]  G. Palacios,et al.  Monkeypox outbreak in Madrid (Spain): Clinical and virological aspects , 2022, The Journal of infection.

[6]  J. Blanco,et al.  Frequent detection of monkeypox virus DNA in saliva, semen, and other clinical samples from 12 patients, Barcelona, Spain, May to June 2022 , 2022, Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin.

[7]  C. Fernández Pérez,et al.  Efficiency of screening for human immunodeficiency virus infection in emergency departments: a systematic review and meta-analysis. , 2022, Emergencias : revista de la Sociedad Espanola de Medicina de Emergencias.

[8]  B. Vuylsteke,et al.  Sexual transmission of infections across Europe: appraising the present, scoping the future , 2022, Sexually Transmitted Infections.

[9]  A. Boyd,et al.  Pharmacodynamics of Ceftriaxone, Ertapenem, Fosfomycin and Gentamicin in Neisseria gonorrhoeae , 2022, Antibiotics.

[10]  M. Unemo,et al.  2021 European guideline on the management of Mycoplasma genitalium infections , 2022, Journal of the European Academy of Dermatology and Venereology : JEADV.

[11]  K. Workowski,et al.  Coinfection With Chlamydial and Gonorrheal Infection Among US Adults With Early Syphilis , 2022, Sexually transmitted diseases.

[12]  K. Ghanem,et al.  Diagnosis and Treatment of Sexually Transmitted Infections: A Review. , 2022, JAMA.

[13]  T. Heijman,et al.  Efficacy of ertapenem, gentamicin, fosfomycin, and ceftriaxone for the treatment of anogenital gonorrhoea (NABOGO): a randomised, non-inferiority trial. , 2022, The Lancet. Infectious diseases.

[14]  M. Unemo,et al.  Antimicrobial resistance prediction in Neisseria gonorrhoeae: current status and future prospects , 2021, Expert review of molecular diagnostics.

[15]  J. Routy,et al.  Multiplexed rapid technologies for sexually transmitted infections: a systematic review. , 2021, The Lancet. Microbe.

[16]  I. F. Romero,et al.  [Sexually Transmitted Infections During the First Wave of the COVID-19 Pandemic in Spain]. , 2021, Actas dermo-sifiliograficas.

[17]  M. Unemo,et al.  WHO global antimicrobial resistance surveillance for Neisseria gonorrhoeae 2017-18: a retrospective observational study. , 2021, The Lancet. Microbe.

[18]  J. Mallolas,et al.  Detection of unknown cases of human immunodeficiency virus infection in emergency departments: a utopian ideal? , 2021, Emergencias : revista de la Sociedad Espanola de Medicina de Emergencias.

[19]  Ò. Miró,et al.  Screening for undiagnosed human immunodeficiency virus infection in Spanish emergency departments: current attitudes, inclination, and perception of obstacles related to the implementation of measures to improve detection. , 2021, Emergencias : revista de la Sociedad Espanola de Medicina de Emergencias.

[20]  K. Workowski,et al.  Sexually Transmitted Infections Treatment Guidelines, 2021 , 2021, MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports.

[21]  B. Davis,et al.  Promoting Healthy Sexuality for Children and Adolescents With Disabilities , 2021, Pediatrics.

[22]  Ò. Miró,et al.  [Map of sexually transmitted disease care in Spanish emergency departments]. , 2021, Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia.

[23]  F. Fischer,et al.  An Evidence Map on Serious Games in Preventing Sexually Transmitted Infections Among Adolescents: Systematic Review About Outcome Categories Investigated in Primary Studies , 2021, JMIR serious games.

[24]  S. Bernal,et al.  Neisseria gonorrhoeae antimicrobial resistance in Spain: a prospective multicentre study. , 2021, The Journal of antimicrobial chemotherapy.

[25]  M. F. Fuentes Ferrer,et al.  Low use of condom and high STI incidence among men who have sex with men in PrEP programs , 2021, PloS one.

[26]  J. González del Castillo Current role of hospital emergency departments in the fight against the human immunodeficiency virus infection pandemic. , 2021, Emergencias : revista de la Sociedad Espanola de Medicina de Emergencias.

[27]  R. Guy,et al.  Comparison of Trends in Rates of Sexually Transmitted Infections Before vs After Initiation of HIV Preexposure Prophylaxis Among Men Who Have Sex With Men , 2020, JAMA network open.

[28]  Ò. Miró,et al.  Recommendations for the early diagnosis of suspected human immunodeficiency virus infection in the emergency department and the referral of patients for follow-up: a consensus statement of the Spanish Society of Emergency Medicine (SEMES). , 2020, Emergencias : revista de la Sociedad Espanola de Medicina de Emergencias.

[29]  M. Unemo,et al.  2020 European guideline for the diagnosis and treatment of gonorrhoea in adults. , 2020, International journal of STD & AIDS.

[30]  C. Holland-Hall,et al.  A review of current guidelines and research on the management of sexually transmitted infections in adolescents and young adults , 2020, Therapeutic advances in infectious disease.

[31]  J. Klausner,et al.  Point-of-Care Testing for Sexually Transmitted Infections: A Review of Recent Developments. , 2020, Archives of pathology & laboratory medicine.

[32]  N. Low,et al.  Prevalence of mutations associated with resistance to macrolides and fluoroquinolones in Mycoplasma genitalium: a systematic review and meta-analysis. , 2020, The Lancet. Infectious diseases.

[33]  H. Jessen,et al.  Emtricitabine and tenofovir alafenamide vs emtricitabine and tenofovir disoproxil fumarate for HIV pre-exposure prophylaxis (DISCOVER): primary results from a randomised, double-blind, multicentre, active-controlled, phase 3, non-inferiority trial , 2020, The Lancet.

[34]  L. Abu-Raddad,et al.  Herpes simplex virus: global infection prevalence and incidence estimates, 2016 , 2020, Bulletin of the World Health Organization.

[35]  M. Fuentes,et al.  Risk factors associated with sexually transmitted infections and HIV among adolescents in a reference clinic in Madrid , 2020, PloS one.

[36]  T. Pumarola,et al.  Mycoplasma genitalium and antimicrobial resistance in Europe: a comprehensive review , 2020, International journal of STD & AIDS.

[37]  S. Sadiq,et al.  2018 UK national guideline for the management of infection with Neisseria gonorrhoeae , 2019, International journal of STD & AIDS.

[38]  M. Cabana,et al.  Preexposure Prophylaxis for the Prevention of HIV Infection: US Preventive Services Task Force Recommendation Statement. , 2019, JAMA.

[39]  R. Chou,et al.  Preexposure Prophylaxis for the Prevention of HIV Infection: Evidence Report and Systematic Review for the US Preventive Services Task Force. , 2019, JAMA.

[40]  Brian L. Price,et al.  Association of HIV Preexposure Prophylaxis With Incidence of Sexually Transmitted Infections Among Individuals at High Risk of HIV Infection , 2019, JAMA.

[41]  J. Parsons,et al.  The Impact of Pre-Exposure Prophylaxis (PrEP) Use on Sexual Anxiety, Satisfaction, and Esteem Among Gay and Bisexual Men , 2019, Journal of sex research.

[42]  S. Garland,et al.  Outcomes of Resistance-guided Sequential Treatment of Mycoplasma genitalium Infections: A Prospective Evaluation , 2018, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[43]  S. Garland,et al.  Use of Pristinamycin for Macrolide-Resistant Mycoplasma genitalium Infection , 2018, Emerging infectious diseases.

[44]  F. Garrett,et al.  Which azithromycin regimen should be used for treating Mycoplasma genitalium? A meta-analysis , 2017, Sexually Transmitted Infections.

[45]  W. Pearson,et al.  An increase in sexually transmitted infections seen in US emergency departments. , 2017, Preventive medicine.

[46]  Steven M Goodreau,et al.  Impact of the Centers for Disease Control's HIV Preexposure Prophylaxis Guidelines for Men Who Have Sex With Men in the United States. , 2016, The Journal of infectious diseases.

[47]  D. Bernstein,et al.  Substantial Decline in Vaccine-Type Human Papillomavirus (HPV) Among Vaccinated Young Women During the First 8 Years After HPV Vaccine Introduction in a Community. , 2016, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[48]  J. Kaldor,et al.  Human Papillomavirus Prevalence in Unvaccinated Heterosexual Men After a National Female Vaccination Program , 2016, The Journal of infectious diseases.

[49]  C. B. Hare,et al.  No New HIV Infections With Increasing Use of HIV Preexposure Prophylaxis in a Clinical Practice Setting. , 2015, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[50]  J. Mcnicholl,et al.  The impact of adherence to preexposure prophylaxis on the risk of HIV infection among people who inject drugs , 2015, AIDS.

[51]  S. Garland,et al.  Macrolide resistance and azithromycin failure in a Mycoplasma genitalium-infected cohort and response of azithromycin failures to alternative antibiotic regimens. , 2015, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[52]  Peter Vickerman,et al.  Global Estimates of Prevalent and Incident Herpes Simplex Virus Type 2 Infections in 2012 , 2015, PloS one.

[53]  L. Trinquart,et al.  Oral antiviral therapy for prevention of genital herpes outbreaks in immunocompetent and nonpregnant patients. , 2014, The Cochrane database of systematic reviews.

[54]  C. Hendrix,et al.  Antiretroviral prophylaxis for HIV infection in injecting drug users in Bangkok, Thailand (the Bangkok Tenofovir Study): a randomised, double-blind, placebo-controlled phase 3 trial , 2013, The Lancet.

[55]  A. Domingo Infecciones de transmisión sexual , 2013, Red Book (2012) - Spanish.

[56]  S. M. Vranic Chlamydia trachomatis Infections of the Adults , 2012 .

[57]  D. Taylor-Robinson,et al.  Mycoplasma genitalium: from Chrysalis to Multicolored Butterfly , 2011, Clinical Microbiology Reviews.

[58]  B. Winkler,et al.  Anal cancer and cervical cancer screening: Key differences , 2011, Cancer cytopathology.

[59]  M. Unemo,et al.  Guidelines for the laboratory diagnosis of mycoplasma genitalium infections in East European countries. , 2010, Acta dermato-venereologica.

[60]  F. A. M. Llop Red Book. Enfermedades Infecciosas en Pediatría , 2008 .

[61]  J. Jensen,et al.  Isolation of Mycoplasma genitalium from First-Void Urine Specimens by Coculture with Vero Cells , 2007, Journal of Clinical Microbiology.

[62]  Margaret-Mary G. Wilson,et al.  Sexually transmitted diseases. , 2003, Clinics in geriatric medicine.

[63]  J. Tully,et al.  In vitro susceptibilities of Mycoplasma genitalium to antibiotics , 1992, Antimicrobial Agents and Chemotherapy.

[64]  J. Tully,et al.  A NEWLY DISCOVERED MYCOPLASMA IN THE HUMAN UROGENITAL TRACT , 1981, The Lancet.

[65]  J. Serra-Pladevall,et al.  Gonococcal infection: An unresolved problem. , 2019, Enfermedades infecciosas y microbiologia clinica.

[66]  P. L. Claret,et al.  Medicina Preventiva y Salud Pública , 2016 .

[67]  R. Evans European Centre for Disease Prevention and Control. , 2014, Nursing standard (Royal College of Nursing (Great Britain) : 1987).

[68]  E. Padilla,et al.  [Incidence of genital infections caused by herpes simplex virus type 1 (HSV-1) from 1995 to 2003]. , 2005, Enfermedades infecciosas y microbiologia clinica.