VARIATIONS IN THE CLINICAL AND ANAESTHETIC PARAMETERS DURING ADMINISTRATION OF ROPIVACAINE AND FENTANYL AS LUMBOSACRAL ANAESTHESIA IN GOATS

The aim of study was to assess the quality of analgesia and record the alteration in clinico-anesthetic indices following epidural administration of ropivacaine alone and its combination with fentanyl. A total of 10 clinically healthy goats of 1-3 years aged and weighing between 10-15 kg were used for the present experiment. All the animals were randomly divided into two groups of five animals each. Ropivacaine (0.75%) @ 1 mg/kg BW was administered epidurally at the lumbosacral space in group 1 whereas, the animals of group 2 were given fentanyl @ 2 μg/kg BW in combination with ropivacaine hydrochloride (1 mg/kg BW). Rectal temperature, respiration rate and heart rate showed nonsignificant (P>0.05) variations in both the groups. Duration of analgesia in the different parts of hindquarter was longer in group II as compared to group I. Analgesia, motor incoordination and sedation depicted greater degree in group II. The results suggest that the ropivacaine alone or in combination with fentanyl produced effective analgesia (sensory and motor) of different parts of the hindquarters with little effect on physiology. However, the combination groups manifested higher degree of analgesia, motor incoordination and sedation.

[1]  P. Pascoe Opioid analgesics , 2018, Reactions weekly.

[2]  A. Gopinathan,et al.  Comparative evaluation of ropivacaine, bupivacaine and xylazine-ketamine combination for epidural analgesia in goats. , 2015 .

[3]  N. Ganai,et al.  Comparison of Two Doses of Ropivacaine Hydrochloride for Lumbosacral Epidural Anaesthesia in Goats Undergoing Laparoscopy Assisted Embryo Transfer , 2014, International scholarly research notices.

[4]  Ankit Jain,et al.  Comparison of intrathecal ropivacaine-fentanyl and bupivacaine-fentanyl for major lower limb orthopaedic surgery: A randomised double-blind study , 2014, Indian journal of anaesthesia.

[5]  M. Ohmichi,et al.  Associations between the pre‐pregnancy body mass index and gestational weight gain with pregnancy outcomes in Japanese women , 2014, The journal of obstetrics and gynaecology research.

[6]  N. Shah,et al.  Comparison of ropivacaine and bupivacaine with fentanyl for caudal epidural in pediatric surgery , 2013, Anesthesia, essays and researches.

[7]  B. Shukla,et al.  RESEARCH ARTICLE Studies on Clinicophysiological and Haematobiochemical Evaluation of Bupivacine , Ropivacaine and Ropivacaine-Xylazine Combination as an Epidural Analgesic in Dogs. , 2013 .

[8]  M. Sozmen,et al.  Evaluation of experimental subarachnoid analgesia with a combination of detomidine and ropivacaine for flank analgesia in cows. , 2012 .

[9]  C. Rodrigues,et al.  Cardiopulmonary and analgesic effects of caudal epidurally administered ropivacaine in cattle. , 2012, Veterinary anaesthesia and analgesia.

[10]  A. Bigham-Sadegh,et al.  Evaluation of anti-nociceptive effect of epidural tramadol, tramadol-lidocaine and lidocaine in goats. , 2012, Veterinary anaesthesia and analgesia.

[11]  A. Bigham,et al.  Comparison of lidocaine, tramadol, and lidocaine-tramadol for epidural analgesia in lambs. , 2011, Research in veterinary science.

[12]  G. Chaudhary,et al.  Ropivacaine: A review of its pharmacology and clinical use , 2011, Indian journal of anaesthesia.

[13]  B. Shukla,et al.  Studies on clinico-physiological and haemato-biochemical changes following epidural analgesia by ropivacaine and ropivacaine-xylazine combination in goats. , 2011 .

[14]  Ayman Qatawneh,et al.  Effect of Adding Dexmedetomidine versus Fentanyl to Intrathecal Bupivacaine on Spinal Block Characteristics in Gynecological Procedures: A Double Blind Controlled Study , 2009 .

[15]  Amarpal,et al.  Comparison of two doses of ropivacaine for lumbosacral epidural analgesia in buffalo calves (Bubalus bubalis) , 2007, Veterinary Record.

[16]  N. Christelis,et al.  A comparison of epidural ropivacaine 0.75% and bupivacaine 0.5% with fentanyl for elective caesarean section. , 2005, International journal of obstetric anesthesia.

[17]  Amarpal,et al.  Clinicophysiological and haematobiochemical effects of epidural ropivacaine in uraemic and healthy caprines , 2005 .

[18]  T. Hansen Ropivacaine: a pharmacological review , 2004, Expert review of neurotherapeutics.

[19]  H. Çetin,et al.  Comparison of ropivacaine with a combination of ropivacaine and fentanyl for the caudal epidural anaesthesia of mares , 2004, Veterinary Record.

[20]  A. Gray,et al.  Amide Local Anesthetics Potently Inhibit the Human Tandem Pore Domain Background K+ Channel TASK-2 (KCNK5) , 2003, Journal of Pharmacology and Experimental Therapeutics.

[21]  C. Natalini,et al.  Epidural anesthesia and analgesia in horses. , 2002, The Veterinary clinics of North America. Equine practice.

[22]  W. Muir,et al.  Analgesic, hemodynamic and respiratory effects of caudal epidurally administered ropivacaine hydrochloride in mares. , 2000, Veterinary anaesthesia and analgesia.

[23]  D. Faulds,et al.  Ropivacaine , 2000, Drugs.

[24]  G. Fanelli,et al.  Patient supplemented epidural analgesia after major abdominal surgery with bupivacaine/fentanyl or ropivacaine/fentanyl , 2000, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

[25]  B. Plaud,et al.  Continuous epidural infusion of ropivacaine for postoperative analgesia after major abdominal surgery: comparative study with i.v. PCA morphine. , 1998, British journal of anaesthesia.

[26]  D. Hendrickson,et al.  Cephalad distribution of three differing volumes of new methylene blue injected into the epidural space in adult goats. , 1996, Veterinary surgery : VS.

[27]  M. Chaney Side effects of intrathecal and epidural opioids , 1995, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

[28]  Blass Ce,et al.  Respiratory paralysis secondary to epidural anesthesia in a dog. , 1986 .

[29]  L. Mather,et al.  Intrathecal and epidural administration of opioids. , 1984, Anesthesiology.

[30]  Skarda Rt,et al.  Hemodynamic and respiratory effects of segmental subarachnoid analgesia in adult Holstein cows. , 1982 .