Additional file 2

------------------------------------I. BASAL 4-STRANDED VERSIONS OF THE β-GF ------------------------------------A. Archaeo-eukaryotic RNA polymerase β-subunit domain superfamily (all eukaryotes, all archaea) function unknown PDB: 1I6HB (residues ~573-631) B. IF3-N terminal domain superfamily (all bacteria, all eukaryotes except Giardia) function unknown PDB: 1TIF (residues ~9-61) C. **POZ superfamily (all eukaryotes) mediates dimerization and transcriptional repression and interacts with histone deacetylase corepressor complexes PDB: 1HV2, several others D. BofC/IGB lineage **Bypass of forespore (Bof)C family (Bacillus, Geobacillus) secreted protein important in spore formation pathway PDB: 2BW2 Immunoglobulin-binding (Ig-binding) family (firmicutes) cell surface virulence protein PDB: 1HEZ, several others E. Other lineages **Yml108w family (budding yeast) function unknown PDB: 1N6Z

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