Influence of nonprotective autophagy and the autophagic switch on sensitivity to cisplatin in non-small cell lung cancer cells.

[1]  D. Gewirtz.  The Switch between Protective and Nonprotective Autophagy; Implications for Autophagy Inhibition as a Therapeutic Strategy in Cancer , 2020, Biology.

[2]  C. Yun,et al.  The Roles of Autophagy in Cancer , 2018, International journal of molecular sciences.

[3]  D. Gewirtz,et al.  Differential Radiation Sensitivity in p53 Wild-Type and p53-Deficient Tumor Cells Associated with Senescence but not Apoptosis or (Nonprotective) Autophagy , 2018, Radiation Research.

[4]  Hui Zhou,et al.  Inhibition of autophagy promotes cisplatin-induced apoptotic cell death through Atg5 and Beclin 1 in A549 human lung cancer cells. , 2018, Molecular medicine reports.

[5]  T. Hwang,et al.  Cisplatin induces protective autophagy through activation of BECN1 in human bladder cancer cells , 2017, Drug design, development and therapy.

[6]  D. Gewirtz,et al.  Autophagy is not uniformly cytoprotective: a personalized medicine approach for autophagy inhibition as a therapeutic strategy in non-small cell lung cancer. , 2016, Biochimica et biophysica acta.

[7]  D. Gewirtz.  The Challenge of Developing Autophagy Inhibition as a Therapeutic Strategy. , 2016, Cancer research.

[8]  E. White,et al.  Recent insights into the function of autophagy in cancer , 2016, Genes & development.

[9]  Feng Dai,et al.  Inhibition of ERα/ERK/P62 cascades induces “autophagic switch” in the estrogen receptor-positive breast cancer cells exposed to gemcitabine , 2016, Oncotarget.

[10]  S. Dilruba,et al.  Platinum-based drugs: past, present and future , 2016, Cancer Chemotherapy and Pharmacology.

[11]  Gregory McAllister,et al.  Macroautophagy is dispensable for growth of KRAS mutant tumors and chloroquine efficacy , 2015, Proceedings of the National Academy of Sciences.

[12]  H. Shim,et al.  Autophagy contributes to the chemo-resistance of non-small cell lung cancer in hypoxic conditions , 2015, Respiratory Research.

[13]  J. Clairambault,et al.  Diverse spatio-temporal dynamical patterns of p53 and cell fate decisions , 2015 .

[14]  A. Chaudhary,et al.  Targeting autophagy to overcome drug resistance in cancer therapy. , 2015, Future medicinal chemistry.

[15]  U. Wolfrum,et al.  Estrogen receptor α regulates non-canonical autophagy that provides stress resistance to neuroblastoma and breast cancer cells and involves BAG3 function , 2015, Cell Death and Disease.

[16]  Wataru Nakajima,et al.  Yet Another Function of p53—The Switch That Determines Whether Radiation-Induced Autophagy Will Be Cytoprotective or Nonprotective: Implications for Autophagy Inhibition as a Therapeutic Strategy , 2015, Molecular Pharmacology.

[17]  E. Sausville,et al.  Autophagy modulation: a target for cancer treatment development , 2015, Cancer Chemotherapy and Pharmacology.

[18]  D. Gewirtz,et al.  A novel cytostatic form of autophagy in sensitization of non-small cell lung cancer cells to radiation by vitamin D and the vitamin D analog, EB 1089 , 2014, Autophagy.

[19]  C. Shaha,et al.  Beclin-1–p53 interaction is crucial for cell fate determination in embryonal carcinoma cells , 2014, Journal of cellular and molecular medicine.

[20]  D. Gewirtz.  An autophagic switch in the response of tumor cells to radiation and chemotherapy. , 2014, Biochemical pharmacology.

[21]  D. Gewirtz.  The four faces of autophagy: implications for cancer therapy. , 2014, Cancer research.

[22]  E. Kleinerman,et al.  Knockdown of autophagy-related protein 5, ATG5, decreases oxidative stress and has an opposing effect on camptothecin-induced cytotoxicity in osteosarcoma cells , 2013, BMC Cancer.

[23]  Z. Huang,et al.  Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment , 2013, Cell Death and Disease.

[24]  D. Gewirtz.  Cytoprotective and nonprotective autophagy in cancer therapy , 2013, Autophagy.

[25]  K. Valerie,et al.  The Autophagy-Senescence Connection in Chemotherapy: Must Tumor Cells (Self) Eat Before They Sleep? , 2012, Journal of Pharmacology and Experimental Therapeutics.

[26]  Y. Zeng,et al.  The Inhibition of Autophagy Sensitises Colon Cancer Cells with Wild-Type p53 but Not Mutant p53 to Topotecan Treatment , 2012, PloS one.

[27]  M. Aghi,et al.  Tumor cell autophagy as an adaptive response mediating resistance to treatments such as antiangiogenic therapy. , 2012, Cancer research.

[28]  Michael M Gottesman,et al.  Cisplatin Resistance: A Cellular Self-Defense Mechanism Resulting from Multiple Epigenetic and Genetic Changes , 2012, Pharmacological Reviews.

[29]  L. Galluzzi,et al.  Molecular mechanisms of cisplatin resistance , 2012, Oncogene.

[30]  A. Thorburn,et al.  Chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagy , 2012, Autophagy.

[31]  F. Di Virgilio,et al.  Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice , 2011, Science.

[32]  D. Gewirtz,et al.  A Switch Between Cytoprotective and Cytotoxic Autophagy in the Radiosensitization of Breast Tumor Cells by Chloroquine and Vitamin D , 2011, Hormones & cancer.

[33]  Y. Zou,et al.  Differential DNA damage responses in p53 proficient and deficient cells: cisplatin-induced nuclear import of XPA is independent of ATR checkpoint in p53-deficient lung cancer cells. , 2011, International journal of biochemistry and molecular biology.

[34]  A. Wen,et al.  Autophagy is a therapeutic target in anticancer drug resistance. , 2010, Biochimica et biophysica acta.

[35]  Gang Wu,et al.  Acquired cisplatin resistance in human lung adenocarcinoma cells is associated with enhanced autophagy. , 2010, Cancer biotherapy & radiopharmaceuticals.

[36]  L. Harhaji-Trajković,et al.  AMPK-mediated autophagy inhibits apoptosis in cisplatin-treated tumour cells , 2009, Journal of cellular and molecular medicine.

[37]  Nektarios Tavernarakis,et al.  Regulation of autophagy by cytoplasmic p53 , 2008, Nature Cell Biology.

[38]  J. Cleveland,et al.  Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance. , 2007, Blood.

[39]  D. Housman,et al.  p53-dependent apoptosis modulates the cytotoxicity of anticancer agents , 1993, Cell.

[40]  The Roles , 2020, Web and Digital for Graphic Designers.

[41]  W. El-Deiry,et al.  Regulation of programmed cell death by the p53 pathway. , 2008, Advances in experimental medicine and biology.