Spatially resolved surface enhanced Raman spectroscopy: feasibility, intensity dependence on sampling area and attomole mass sensitivity

Abstract Spatially resolved surface enhanced Raman scattering (SR SERS) from μm sized sampling areas has been observed in the electrochemical environment for the first time. Analysis of the equation for SR SERS intensity reveals that the detected signal should be area independent. This is demonstrated experimentally for the aqueous pyridine/Ag model system using 200 kW cm −2 peak laser irradiance. The mass detection limits for SR SERS are found to be on the order of 10 5 molecules or 0.17 attomoles!

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