Electrogastrography and gastric emptying scintigraphy are complementary for assessment of dyspepsia.

We have tried to correlate abnormalities in electrogastrography (EGG) and gastric emptying (GE) with symptom severity in patients with functional dyspepsia. Seventy-two patients with functional dyspepsia underwent EGG, GE, and symptom severity quantitation. EGGs were assessed for dominant frequency (DF), percentage of time of DF in the 2 to 4 cpm range, and postprandial-fasting DF power ratio. Solid-phase GE scintigraphy was assessed for 2-hour percentage retention. Symptoms of upper abdominal discomfort, early satiety, postprandial abdominal distension, nausea, vomiting, and anorexia were graded as none (0), mild (1), moderate (2), and severe (3); the sum represented a total symptom score. The EGG was abnormal in 11 of 22 (50%) patients with delayed GE compared with 11 of 50 (22%) with normal GE (p < 0.025). The total symptom scores were higher in patients with both delayed GE and abnormal EGG compared with patients with normal GE and EGG, normal GE and abnormal EGG, and delayed GE and normal EGG. We conclude that EGG abnormalities are more common in dyspeptic patients with delayed GE. Patients with both delayed GE and abnormal EGG have more severe symptoms. Our results suggest that EGG and GE complement each other in correlating symptoms to gastric dysmotility.

[1]  R. Fisher,et al.  Influence of age, gender, and menstrual cycle on the normal electrogastrogram. , 1996, The American journal of gastroenterology.

[2]  B. Krevsky,et al.  Comparison of left anterior oblique and geometric mean gastric emptying. , 1991, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[3]  J. Malagelada,et al.  Manometric evaluation of functional upper gut symptoms. , 1985, Gastroenterology.

[4]  J Chen,et al.  Gastric slow wave abnormalities in patients with gastroparesis. , 1992, The American journal of gastroenterology.

[5]  F. Leverkus,et al.  Frequency of Idiopathic Gastric Stasis and Intestinal Transit Disorders in Essential Dyspepsia , 1989, Journal of clinical gastroenterology.

[6]  F. Campbell,et al.  Evidence for hypomotility in non-ulcer dyspepsia: a prospective multifactorial study. , 1991, Gut.

[7]  W. Chey,et al.  Electrogastrographic study of patients with unexplained nausea, bloating, and vomiting. , 1980, Gastroenterology.

[8]  J. Chen,et al.  Clinical applications of electrogastrography. , 1993, The American journal of gastroenterology.

[9]  J. Malagelada,et al.  The origin of symptoms on the brain-gut axis in functional dyspepsia. , 1991, Gastroenterology.

[10]  O. Nyrén,et al.  Irritable bowel syndrome and dyspepsia in the general population: overlap and lack of stability over time. , 1995, Gastroenterology.

[11]  L. Bolondi,et al.  Patterns of gastric emptying in dysmotility-like dyspepsia. , 1995, Scandinavian journal of gastroenterology.

[12]  J. Grashuis,et al.  Electrogastrographic study of gastric myoelectrical activity in patients with unexplained nausea and vomiting. , 1986, Gut.

[13]  G. Barbara,et al.  Risk indicators of delayed gastric emptying of solids in patients with functional dyspepsia. , 1996, Gastroenterology.

[14]  Michael Camilleri,et al.  Gastric electromechanical function and gastric emptying in diabetic gastroparesis , 1991 .

[15]  J. Kalbfleisch,et al.  Gastric emptying in patients with diabetes mellitus. , 1984, Gastroenterology.

[16]  B. Shuter,et al.  Lack of association between gastric emptying of solids and symptoms in nonulcer dyspepsia. , 1989, Journal of clinical gastroenterology.

[17]  A. Alavi,et al.  Metoclopramide to treat gastroparesis due to diabetes mellitus: a double-blind, controlled trial. , 1982, Annals of internal medicine.

[18]  D. Thompson,et al.  Abnormal intragastric distribution of food during gastric emptying in functional dyspepsia patients. , 1994, Gut.

[19]  B. Krevsky,et al.  Whole-gut transit scintigraphy in the evaluation of small-bowel and colon transit disorders. , 1995, Seminars in nuclear medicine.

[20]  R S Fisher,et al.  Gastroduodenal motility and dysmotility: an update on techniques available for evaluation. , 1995, The American journal of gastroenterology.

[21]  R. Fisher,et al.  Dynamic antral scintigraphy to characterize gastric antral motility in functional dyspepsia. , 1995, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[22]  R. Stern,et al.  Gastric emptying and gastric myoelectrical activity in patients with diabetic gastroparesis: effect of long-term domperidone treatment. , 1989, The American journal of gastroenterology.