Development of a novel indwelling balloon applicator for optimizing light delivery in photodynamic therapy

A human glioma spheroid model is used to investigate the efficacy of different light delivery schemes in 5‐aminolevulinic acid (ALA)—mediated photodynamic therapy (PDT). The results provide the rationale for the development of an indwelling balloon applicator for optimizing light delivery.

[1]  Bruce J. Tromberg,et al.  Characterization of optical and thermal distributions from an intracranial balloon applicator for photodynamic therapy , 2001, SPIE BiOS.

[2]  Brian C. Wilson,et al.  Photofrin photodynamic therapy for malignant brain tumors , 2001, SPIE BiOS.

[3]  B. Henderson,et al.  Reduction of tumour oxygenation during and after photodynamic therapy in vivo: effects of fluence rate. , 1998, British Journal of Cancer.

[4]  L. Lilge,et al.  Photodynamic therapy of intracranial tissues: a preclinical comparative study of four different photosensitizers. , 1998, Journal of clinical laser medicine & surgery.

[5]  B. Henderson,et al.  The Effect of Fluence Rate on Tumor and Normal Tissue Responses to Photodynamic Therapy , 1998, Photochemistry and photobiology.

[6]  H Stepp,et al.  Intraoperative detection of malignant gliomas by 5-aminolevulinic acid-induced porphyrin fluorescence. , 1998, Neurosurgery.

[7]  J Moan,et al.  5‐Aminolevulinic acid‐based photodynamic therapy , 1997, Cancer.

[8]  D. Kessel,et al.  Side effects and photosensitization of human tissues after aminolevulinic acid. , 1997, The Journal of surgical research.

[9]  Q. Peng,et al.  5‐Aminolevulinic Acid‐Based Photodynamic Therapy: Principles and Experimental Research , 1997, Photochemistry and photobiology.

[10]  M G Nichols,et al.  The Mechanism of Photofrin Photobleaching and Its Consequences for Photodynamic Dosimetry , 1997, Photochemistry and photobiology.

[11]  A H Kaye,et al.  Photodynamic therapy of brain tumors. , 1996, Seminars in surgical oncology.

[12]  H. Oppelaar,et al.  Influence of fractionation and fluence rate in photodynamic therapy with Photofrin or mTHPC. , 1996, Radiation research.

[13]  L. O. Svaasand,et al.  A mathematical model for light dosimetry in photodynamic destruction of human endometrium. , 1996, Physics in medicine and biology.

[14]  A H Kaye,et al.  Photodynamic therapy of brain tumors. , 1995, Journal of clinical laser medicine & surgery.

[15]  B. Wilson,et al.  Photodynamic therapy for recurrent supratentorial gliomas. , 1995, Seminars in surgical oncology.

[16]  M G Nichols,et al.  Fluence rate effects in photodynamic therapy of multicell tumor spheroids. , 1993, Cancer research.

[17]  S. Gibson,et al.  Effects of various photoradiation regimens on the antitumor efficacy of photodynamic therapy for R3230AC mammary carcinomas. , 1990, Cancer research.

[18]  K. Wallner,et al.  Patterns of failure following treatment for glioblastoma multiforme and anaplastic astrocytoma. , 1989, International journal of radiation oncology, biology, physics.

[19]  H. Pass,et al.  In vitro photodynamic therapy of human lung cancer: investigation of dose-rate effects. , 1989, Cancer research.

[20]  J. Moore,et al.  The effect of fractionation of light treatment on necrosis and vascular function of normal skin following photodynamic therapy. , 1988, British Journal of Cancer.

[21]  I Rosenthal,et al.  Effect of light fluence rate on mammalian cells photosensitization by chloroaluminium phthalocyanine tetrasulphonate. , 1987, International journal of radiation biology and related studies in physics, chemistry, and medicine.

[22]  B. Wilson,et al.  An update on the penetration depth of 630 nm light in normal and malignant human brain tissue in vivo. , 1986, Physics in medicine and biology.

[23]  B. Wilson,et al.  Photo-Dynamic Therapy: Cavitary Photo-Illumination of Malignant Cerebral Tumours Using a Laser Coupled Inflatable Balloon , 1985, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[24]  L. O. Svaasand,et al.  OPTICAL PENETRATION IN HUMAN INTRACRANIAL TUMORS , 1985, Photochemistry and photobiology.

[25]  L. O. Svaasand,et al.  OPTICAL PROPERTIES OF HUMAN BRAIN , 1983, Photochemistry and photobiology.

[26]  T J Dougherty,et al.  Photoradiation in the treatment of recurrent breast carcinoma. , 1979, Journal of the National Cancer Institute.

[27]  H. Hirschberg,et al.  Intracavity Fractionated Balloon Brachytherapy in Glioblastoma , 1999, Acta Neurochirurgica.

[28]  M. Kao,et al.  Comparative study on the ALA photodynamic effects of human glioma and meningioma cells , 1999, Lasers in surgery and medicine.

[29]  T. Dougherty Photodynamic therapy. , 1993, Photochemistry and photobiology.

[30]  R. Sutherland,et al.  Radiation response of multicell spheroids--an in vitro tumour model. , 1976, Current topics in radiation research quarterly.

[31]  Durand Re,et al.  Radiation response of multicell spheroids--an in vitro tumour model. , 1976 .