Detectionof Major Depressive Disorder Based on a Combination of Voice Features: An Exploratory Approach

In general, it is common knowledge that people’s feelings are reflected in their voice and facial expressions. This research work focuses on developing techniques for diagnosing depression based on acoustic properties of the voice. In this study, we developed a composite index of vocal acoustic properties that can be used for depression detection. Voice recordings were collected from patients undergoing outpatient treatment for major depressive disorder at a hospital or clinic following a physician’s diagnosis. Numerous features were extracted from the collected audio data using openSMILE software. Furthermore, qualitatively similar features were combined using principal component analysis. The resulting components were incorporated as parameters in a logistic regression based classifier, which achieved a diagnostic accuracy of ~90% on the training set and ~80% on the test set. Lastly, the proposed metric could serve as a new measure for evaluation of major depressive disorder.

[1]  S. Tokuno,et al.  Depressive Mood Assessment Method Based on Emotion Level Derived from Voice: Comparison of Voice Features of Individuals with Major Depressive Disorders and Healthy Controls , 2021, International journal of environmental research and public health.

[2]  S. Tokuno,et al.  Effectiveness of a Voice-Based Mental Health Evaluation System for Mobile Devices: Prospective Study , 2020, JMIR formative research.

[3]  G. Fava,et al.  The Hamilton Rating Scales for Depression: A Critical Review of Clinimetric Properties of Different Versions , 2020, Psychotherapy and Psychosomatics.

[4]  Masakazu Higuchi,et al.  CLASSIFICATION OF BIPOLAR DISORDER, MAJOR DEPRESSIVE DISORDER, AND HEALTHY STATE USING VOICE , 2018, Asian Journal of Pharmaceutical and Clinical Research.

[5]  Ryuki Tachibana,et al.  Major depressive disorder discrimination using vocal acoustic features. , 2018, Journal of affective disorders.

[6]  Zhenyu Liu,et al.  Investigation of different speech types and emotions for detecting depression using different classifiers , 2017, Speech Commun..

[7]  Masakazu Higuchi,et al.  Validity of mind monitoring system as a mental health indicator using voice , 2017 .

[8]  J. Bardram,et al.  Voice analysis as an objective state marker in bipolar disorder , 2016, Translational psychiatry.

[9]  J. Thome,et al.  Current source density analysis of resting state EEG in depression: a review , 2017, Journal of Neural Transmission.

[10]  Fan Zhang,et al.  Automatic Depression Scale Prediction using Facial Expression Dynamics and Regression , 2014, AVEC '14.

[11]  Shinichi Tokuno,et al.  Decreased Plasma Brain-Derived Neurotrophic Factor and Vascular Endothelial Growth Factor Concentrations during Military Training , 2014, PloS one.

[12]  R Core Team,et al.  R: A language and environment for statistical computing. , 2014 .

[13]  J. Mundt,et al.  Vocal Acoustic Biomarkers of Depression Severity and Treatment Response , 2012, Biological Psychiatry.

[14]  S. Pollak,et al.  Instant messages vs. speech: hormones and why we still need to hear each other. , 2012, Evolution and human behavior : official journal of the Human Behavior and Evolution Society.

[15]  T. Higuchi,et al.  Cost of depression among adults in Japan. , 2011, The primary care companion for CNS disorders.

[16]  Jürgen Kayser,et al.  In search of the Rosetta Stone for scalp EEG: Converging on reference-free techniques , 2010, Clinical Neurophysiology.

[17]  H. Möller,et al.  Response and remission criteria in major depression--a validation of current practice. , 2010, Journal of psychiatric research.

[18]  Björn Schuller,et al.  Opensmile: the munich versatile and fast open-source audio feature extractor , 2010, ACM Multimedia.

[19]  N. Iwata,et al.  Duration of untreated illness and antidepressant fluvoxamine response in major depressive disorder , 2010, Psychiatry and clinical neurosciences.

[20]  Trevor Hastie,et al.  Regularization Paths for Generalized Linear Models via Coordinate Descent. , 2010, Journal of statistical software.

[21]  Shuhei Izawa,et al.  Salivary dehydroepiandrosterone secretion in response to acute psychosocial stress and its correlations with biological and psychological changes , 2008, Biological Psychology.

[22]  S. Jin,et al.  Clinical analysis of voice change as a parameter of premenstrual syndrome. , 2001, Journal of voice : official journal of the Voice Foundation.

[23]  R. Spitzer,et al.  The PHQ-9: validity of a brief depression severity measure. , 2001, Journal of general internal medicine.

[24]  J. Abitbol,et al.  Sex hormones and the female voice. , 1999, Journal of voice : official journal of the Voice Foundation.

[25]  D. Sheehan,et al.  The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. , 1998, The Journal of clinical psychiatry.

[26]  E. Bosmans,et al.  Increased serum interleukin-1-receptor-antagonist concentrations in major depression. , 1995, Journal of affective disorders.

[27]  R. Kessler,et al.  Measuring stress: A guide for health and social scientists. , 1995 .

[28]  J. Rabe-Jabłońska,et al.  [Affective disorders in the fourth edition of the classification of mental disorders prepared by the American Psychiatric Association -- diagnostic and statistical manual of mental disorders]. , 1993, Psychiatria polska.

[29]  Yoshinori Kitahara,et al.  Prosodic Control to Express Emotions for Man-Machine Speech Interaction , 1992 .

[30]  Paul Ekman,et al.  Facial Expressions of Emotion: New Findings, New Questions , 1992 .

[31]  R. C. Young,et al.  A Rating Scale for Mania: Reliability, Validity and Sensitivity , 1978, British Journal of Psychiatry.

[32]  A. Beck,et al.  An inventory for measuring depression. , 1961, Archives of general psychiatry.

[33]  Robert G. D. Steel,et al.  A Rank Sum Test for Comparing All Pairs of Treatments , 1960 .

[34]  M. Hamilton A RATING SCALE FOR DEPRESSION , 1960, Journal of neurology, neurosurgery, and psychiatry.