LTP is accompanied by commensurate enhancement of auditory-evoked responses in a fear conditioning circuit

Transmission of auditory information from the medial geniculate body to the lateral nucleus of the amygdala is believed to be involved in the conditioning of fear responses to acoustic stimuli. This pathway exhibits LTP of electrically evoked field potentials after high frequency stimulation of the medial geniculate body. High frequency stimulation of the medial geniculate body also results in a long-lasting potentiation of a field potential in the lateral amygdala elicited by a naturally transduced acoustic stimulus. This demonstrates that natural information processing can make use of the physiological mechanisms set in motion by LTP induction.

[1]  R. Bolles,et al.  Naloxone and shock-elicited freezing in the rat. , 1979 .

[2]  Mark E. Bouton,et al.  Sources of relapse after extinction in Pavlovian and instrumental learning , 1991 .

[3]  James L. McGaugh,et al.  Brain and memory : modulation and mediation of neuroplasticity , 1995 .

[4]  E. Kandel,et al.  Cellular neurophysiological approaches in the study of learning. , 1968, Physiological reviews.

[5]  Joseph E LeDoux.  Emotion: clues from the brain. , 1995, Annual review of psychology.

[6]  Joseph E LeDoux,et al.  Information cascade from primary auditory cortex to the amygdala: corticocortical and corticoamygdaloid projections of temporal cortex in the rat. , 1993, Cerebral cortex.

[7]  Joseph E LeDoux,et al.  Projections to the subcortical forebrain from anatomically defined regions of the medial geniculate body in the rat , 1985, The Journal of comparative neurology.

[8]  Joseph E. LeDoux,et al.  Emotion and the amygdala. , 1992 .

[9]  A. Graybiel,et al.  Responses of tonically active neurons in the primate's striatum undergo systematic changes during behavioral sensorimotor conditioning , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[10]  E. J. Thompson,et al.  The Amygdala. Neurobiological Aspects of Emotion, Memory and Mental Dysfunction , 1992 .

[11]  W J Jacobs,et al.  Stress-induced recovery of fears and phobias. , 1985, Psychological review.

[12]  Michael Davis,et al.  The role of the amygdala in conditioned fear. , 1992 .

[13]  M. Fanselow.  Neural organization of the defensive behavior system responsible for fear , 1994, Psychonomic bulletin & review.

[14]  P. Calabresi,et al.  Long-term synaptic depression in the striatum: physiological and pharmacological characterization , 1992, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[15]  R. Nicoll,et al.  Mechanisms underlying long-term potentiation of synaptic transmission. , 1991, Annual review of neuroscience.

[16]  R. Nicoll,et al.  NMDA-receptor-dependent synaptic plasticity: multiple forms and mechanisms , 1993, Trends in Neurosciences.

[17]  C. Cotman,et al.  Distribution of N-methyl-D-aspartate-sensitive L-[3H]glutamate-binding sites in rat brain , 1985, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[18]  G. Paxinos,et al.  The Rat Brain in Stereotaxic Coordinates , 1983 .

[19]  J. Konorski.  Integrative activity of the brain , 1967 .

[20]  G. Lynch,et al.  Synapses, circuits, and the beginnings of memory , 1986 .

[21]  Joseph E LeDoux,et al.  Synaptic plasticity in fear conditioning circuits: induction of LTP in the lateral nucleus of the amygdala by stimulation of the medial geniculate body , 1990, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[22]  T. Bliss,et al.  Long‐lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path , 1973, The Journal of physiology.

[23]  A. Graybiel,et al.  Effect of the nigrostriatal dopamine system on acquired neural responses in the striatum of behaving monkeys. , 1994, Science.

[24]  E. W. Kairiss,et al.  Long‐Term synaptic potentiation in the amygdala , 1990, Synapse.

[25]  Parallel Properties of Long-Term Potentiation and Memory , 1995 .

[26]  Heterosynaptic long-term facilitation of sensory-evoked responses in the auditory cortex by stimulation of the magnocellular medial geniculate body in guinea pigs. , 1995, Behavioral neuroscience.

[27]  S. Southwick,et al.  Psychobiologic mechanisms of posttraumatic stress disorder. , 1993, Archives of general psychiatry.

[28]  Joseph E. LeDoux,et al.  Overlapping projections to the amygdala and striatum from auditory processing areas of the thalamus and cortex , 1991, Neuroscience Letters.

[29]  T. Teyler.  Long-term potentiation and memory. , 1987, International journal of neurology.

[30]  Michael Davis,et al.  Neurotransmission in the rat amygdala related to fear and anxiety , 1994, Trends in Neurosciences.

[31]  Arne Öhman,et al.  Fear and anxiety as emotional phenomena: Clinical phenomenology, evolutionary perspectives, and information-processing mechanisms. , 1993 .

[32]  Joseph E LeDoux,et al.  Sensory tuning beyond the sensory system: an initial analysis of auditory response properties of neurons in the lateral amygdaloid nucleus and overlying areas of the striatum , 1992, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[33]  Joseph E LeDoux,et al.  Unit responses evoked in the amygdala and striatum by electrical stimulation of the medial geniculate body , 1990, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[34]  R. Pitman,et al.  Conditioned fear and psychological trauma , 1992, Biological Psychiatry.

[35]  W. Singer,et al.  Long-term potentiation and NMDA receptors in rat visual cortex , 1987, Nature.

[36]  J. Edeline,et al.  Stimulation at a site of auditory-somatosensory convergence in the medial geniculate nucleus is an effective unconditioned stimulus for fear conditioning. , 1992, Behavioral neuroscience.

[37]  T. Bliss,et al.  A synaptic model of memory: long-term potentiation in the hippocampus , 1993, Nature.

[38]  A M Graybiel,et al.  The basal ganglia and adaptive motor control. , 1994, Science.

[39]  E. Fischer.  Conditioned Reflexes , 1942, American journal of physical medicine.

[40]  P. Calabresi,et al.  Coactivation of D1 and D2 dopamine receptors is required for long-term synaptic depression in the striatum , 1992, Neuroscience Letters.

[41]  Joseph E LeDoux,et al.  Organization of rodent auditory cortex: anterograde transport of PHA-L from MGv to temporal neocortex. , 1993, Cerebral cortex.

[42]  F. Mascagni,et al.  Corticoamygdaloid and corticocortical projections of the rat temporal cortex: APhaseolus vulgaris leucoagglutinin study , 1993, Neuroscience.

[43]  Joseph E LeDoux,et al.  The lateral amygdaloid nucleus: sensory interface of the amygdala in fear conditioning , 1990, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[44]  E. Bizzi,et al.  The Cognitive Neurosciences , 1996 .

[45]  M. Herkenham,et al.  Thalamoamygdaloid projections in the rat: A test of the amygdala's role in sensory processing , 1991, The Journal of comparative neurology.

[46]  Norman M. Weinberger,et al.  Retuning the brain by fear conditioning. , 1995 .

[47]  A. Ganong,et al.  Excitatory amino acid neurotransmission: NMDA receptors and Hebb-type synaptic plasticity. , 1988, Annual review of neuroscience.

[48]  E. W. Kairiss,et al.  Long-term synaptic potentiation. , 1988, Science.

[49]  Paul J. Whalen,et al.  Amygdaloid contributions to conditioned arousal and sensory information processing. , 1992 .

[50]  L. W. Leung,et al.  Field Potentials in the Central Nervous System , 1990 .

[51]  Joseph E LeDoux,et al.  Neurons of the acoustic thalamus that project to the amygdala contain glutamate , 1991, Neuroscience Letters.

[52]  D. O. Hebb,et al.  The organization of behavior , 1988 .