Cerenkov radiation: a multi-functional approach for biological sciences

Cerenkov radiation (CR) has been used in various biological research fields, which has aroused lots of attention in recent years. Combining optical imaging instruments and most of nuclear medicine imaging or radiotherapy probes, the CR was developed as a new imaging modality for biology studies, called Cerenkov luminescence imaging (CLI). On the other hand, it was novelly used as an internal excitation source to activate some fluorophores for energy transfer imaging. However, it also has some shortages such as relatively weak luminescence intensity and low penetration in tissue. Thus some scientific groups demonstrated to optimize the CLI and demonstrated it to three-dimension tomography. In this article, we elaborate on its principle, history, and applications and discuss a number of directions for technical improvements. Then concluded some advantages and shortages of CR and discuss some prospects of it.

[1]  Jie Tian,et al.  Comparison of Cerenkov luminescence imaging (CLI) and gamma camera imaging for visualization of let-7 expression in lung adenocarcinoma A549 Cells. , 2012, Nuclear medicine and biology.

[2]  Se-Il Park,et al.  Luminescence imaging using radionuclides: a potential application in molecular imaging. , 2011, Nuclear medicine and biology.

[3]  Jan Grimm,et al.  Cerenkov imaging - a new modality for molecular imaging. , 2012, American journal of nuclear medicine and molecular imaging.

[4]  E. Graves,et al.  The potential for Cerenkov luminescence imaging of alpha-emitting radionuclides , 2012, Physics in medicine and biology.

[5]  R. Weissleder.  Molecular Imaging in Cancer , 2006, Science.

[6]  S R Cherry,et al.  Optical imaging of Cerenkov light generation from positron-emitting radiotracers , 2009, Physics in medicine and biology.

[7]  Jan Grimm,et al.  Positron Lymphography: Multimodal, High-Resolution, Dynamic Mapping and Resection of Lymph Nodes After Intradermal Injection of 18F-FDG , 2012, The Journal of Nuclear Medicine.

[8]  K. Günther,et al.  A rapid method for determining 89Sr and 90Sr by Cerenkov counting. , 2009, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[9]  Zhen Cheng,et al.  Proof-of-Concept Study of Monitoring Cancer Drug Therapy with Cerenkov Luminescence Imaging , 2012, The Journal of Nuclear Medicine.

[10]  R. P. Parker,et al.  The assay of β-emitting radioisotopes using Čerenkov counting , 1966 .

[11]  Matthew D Silva,et al.  Multimodal Imaging with 18F-FDG PET and Cerenkov Luminescence Imaging After MLN4924 Treatment in a Human Lymphoma Xenograft Model , 2011, The Journal of Nuclear Medicine.

[12]  R. P. Parker,et al.  The use of Cerenkov radiation in the measurement of β-emitting radionuclides , 1968 .

[13]  Younan Xia,et al.  Radioluminescent gold nanocages with controlled radioactivity for real-time in vivo imaging. , 2013, Nano letters.

[14]  Simon R Cherry,et al.  Cerenkov luminescence tomography for small-animal imaging. , 2010, Optics letters.

[15]  Jie Tian,et al.  Experimental Cerenkov luminescence tomography of the mouse model with SPECT imaging validation. , 2010, Optics express.

[16]  Scott C Davis,et al.  Projection imaging of photon beams using Čerenkov-excited fluorescence , 2013, Physics in medicine and biology.

[17]  Jie Tian,et al.  L1-regularized Cerenkov luminescence tomography with a SP3 method and CT fusion , 2011, 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[18]  Wolfgang Bäumler,et al.  Ion-induced stacking of photosensitizer molecules can remarkably affect the luminescence detection of singlet oxygen in Candida albicans cells , 2013, Journal of biomedical optics.

[19]  Wook Jae Yoo,et al.  Application of Cerenkov radiation generated in plastic optical fibers for therapeutic photon beam dosimetry , 2013, Journal of biomedical optics.

[20]  Lei Xing,et al.  Radioluminescent nanophosphors enable multiplexed small-animal imaging , 2012, Optics express.

[21]  S. Cherry,et al.  Comments on ‘Cerenkov radiation allows in vivo optical imaging of positron emitting radiotracers’ , 2010, Physics in medicine and biology.

[22]  R Calandrino,et al.  Optical imaging of radioisotopes: a novel multimodal approach to molecular imaging. , 2012, The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of....

[23]  R. Leahy,et al.  Hyperspectral and multispectral bioluminescence optical tomography for small animal imaging , 2005, Physics in medicine and biology.

[24]  H. Ning,et al.  Elimination of Cerenkov interference in a fibre-optic-coupled radiation dosemeter. , 2006, Radiation Protection Dosimetry.

[25]  Simon R. Cherry,et al.  In vivo Cerenkov luminescence imaging: a new tool for molecular imaging , 2011, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[26]  Brian W. Pogue,et al.  Čerenkov radiation emission and excited luminescence (CREL) sensitivity during external beam radiation therapy: Monte Carlo and tissue oxygenation phantom studies , 2012, Biomedical optics express.

[27]  Vikram D Kodibagkar,et al.  On the potential for molecular imaging with Cerenkov luminescence. , 2010, Optics letters.

[28]  Scott C Davis,et al.  Three-dimensional Čerenkov tomography of energy deposition from ionizing radiation beams. , 2013, Optics letters.

[29]  Anna Moore,et al.  In Vivo Photoactivation Without “Light”: Use of Cherenkov Radiation to Overcome the Penetration Limit of Light , 2011, Molecular Imaging and Biology.

[30]  H. Balter.  Handbook of nuclear chemistry, volumes 1–5. A. Vértes, S. Nagy, Z. Klencsár (Eds), Kluwer Academic Publishers, Dordrecht. 2003. lviii + 2,444 pp, hardcover 16.7×24.6 cm. € 1,600.00, US$ 1,575.00, GBP 1,000.00. ISBN 1-4020-1305-1 , 2005, European Journal of Nuclear Medicine and Molecular Imaging.

[31]  Zhen Cheng,et al.  Cerenkov Luminescence Imaging (CLI) for cancer therapy monitoring. , 2012, Journal of visualized experiments : JoVE.

[32]  B. Francois.  Detection of hard beta-emitting radionuclides in aqueous solutions using Cerenkov radiation: a review article. , 1973, International journal of nuclear medicine and biology.

[33]  Samuel Achilefu,et al.  Activatable probes based on distance-dependent luminescence associated with Cerenkov radiation. , 2013, Angewandte Chemie.

[34]  Zhen Cheng,et al.  Harnessing the Power of Radionuclides for Optical Imaging: Cerenkov Luminescence Imaging , 2011, The Journal of Nuclear Medicine.

[35]  Michael Höckel,et al.  Impact of Hemoglobin Levels on Tumor Oxygenation: the Higher, the Better? , 2006, Strahlentherapie und Onkologie.

[36]  Radiation of particles moving at a velocity exceeding that of light , and some of the possibilities for their use in experimental physics , .

[37]  E. Baudin,et al.  Radioiodine therapy for papillary and follicular thyroid carcinoma , 2002, European Journal of Nuclear Medicine and Molecular Imaging.

[38]  Byeong-Cheol Ahn,et al.  Combined Cerenkov luminescence and nuclear imaging of radioiodine in the thyroid gland and thyroid cancer cells expressing sodium iodide symporter: initial feasibility study. , 2011, Endocrine journal.

[39]  Brian W. Pogue,et al.  Quantitative Cherenkov emission spectroscopy for tissue oxygenation assessment , 2012, Optics express.

[40]  Jie Tian,et al.  Cerenkov Luminescence Tomography of Aminopeptidase N (APN/CD13) Expression in Mice Bearing HT1080 Tumors , 2013, Molecular imaging.

[41]  R. Weissleder.  A clearer vision for in vivo imaging , 2001, Nature Biotechnology.

[42]  Arion F. Chatziioannou,et al.  Čerenkov radiation imaging as a method for quantitative measurements of beta particles in a microfluidic chip , 2008 .

[43]  W. Burch.  Čerenkov Light from 32P as an Aid to Diagnosis of Eye Tumours , 1971, Nature.

[44]  Federico Boschi,et al.  Unsupervised analysis of small animal dynamic Cerenkov luminescence imaging. , 2011, Journal of biomedical optics.

[45]  Jie Tian,et al.  Single photon emission computed tomography-guided Cerenkov luminescence tomography , 2012 .

[46]  Louis Archambault,et al.  Comment on 'Plastic scintillation dosimetry: comparison of three solutions for the Cerenkov challenge'. , 2012, Physics in medicine and biology.

[47]  Hai-Feng Liu,et al.  Functional imaging and endoscopy. , 2011, World journal of gastroenterology.

[48]  Kyung-Han Lee,et al.  Binding of 2-[18F]fluoro-CP-118,954 to mouse acetylcholinesterase: microPET and ex vivo Cerenkov luminescence imaging studies. , 2011, Nuclear medicine and biology.

[49]  Wook Jae Yoo,et al.  Fiber-optic Cerenkov radiation sensor for proton therapy dosimetry. , 2012, Optics express.

[50]  John L. Humm,et al.  Quantitative Modeling of Cerenkov Light Production Efficiency from Medical Radionuclides , 2012, PloS one.

[51]  Zhen Cheng,et al.  Cerenkov luminescence imaging , 2013 .

[52]  Jan Grimm,et al.  Clinical Cerenkov Luminescence Imaging of 18F-FDG , 2014, The Journal of Nuclear Medicine.

[53]  N Suchowerska,et al.  A plastic scintillation dosimeter for high dose rate brachytherapy , 2006, Physics in medicine and biology.

[54]  Giovanni Lucignani,et al.  Čerenkov radioactive optical imaging: a promising new strategy , 2011, European Journal of Nuclear Medicine and Molecular Imaging.

[55]  Agata Nowak-Stępniowska,et al.  [Photodynamic method of cancer diagnosis and therapy--mechanisms and applications]. , 2013, Postepy biochemii.

[56]  Lei Xing,et al.  Intraoperative Imaging of Tumors Using Cerenkov Luminescence Endoscopy: A Feasibility Experimental Study , 2012, The Journal of Nuclear Medicine.

[57]  Jan Grimm,et al.  Intraoperative Imaging of Positron Emission Tomographic Radiotracers Using Cerenkov Luminescence Emissions , 2011, Molecular imaging.

[58]  S. Brown,et al.  Cerenkov radiation and its applications , 1955 .

[59]  Andrea Sbarbati,et al.  Cerenkov radiation allows in vivo optical imaging of positron emitting radiotracers , 2010, Physics in medicine and biology.

[60]  Jan Grimm,et al.  Quantitative imaging of disease signatures through radioactive decay signal conversion , 2013, Nature Medicine.

[61]  Riccardo Calandrino,et al.  Multispectral Cerenkov luminescence tomography for small animal optical imaging. , 2011, Optics express.

[62]  Jie Tian,et al.  Fast-Specific Tomography Imaging via Cerenkov Emission , 2012, Molecular Imaging and Biology.

[63]  R. P. Parker,et al.  The use of Cerenkov radiation in the measurement of beta-emitting radionuclides. , 1968, The International journal of applied radiation and isotopes.

[64]  S. Gambhir,et al.  RESEARCH ARTICLE Evaluation of 89 Zr-rituximab Tracer by Cerenkov Luminescence Imaging and Correlation with PET in a Humanized Transgenic Mouse Model to Image NHL , 2013 .

[65]  Carlo Cavedon,et al.  First human Cerenkography , 2013, Journal of biomedical optics.

[66]  Federico Boschi,et al.  Optimizing in vivo small animal Cerenkov luminescence imaging. , 2012, Journal of biomedical optics.

[67]  Jan Grimm,et al.  Cerenkov Luminescence Imaging of Medical Isotopes , 2010, Journal of Nuclear Medicine.

[68]  N Suchowerska,et al.  Cerenkov-free scintillation dosimetry in external beam radiotherapy with an air core light guide , 2008, Physics in medicine and biology.

[69]  R. D. Smith,et al.  The use of Cerenkov radiation in 32 P labeled platelet survival studies. , 1972, The International journal of applied radiation and isotopes.

[70]  C. Kuo,et al.  Cerenkov Luminescence Imaging of Interscapular Brown Adipose Tissue , 2014, Journal of visualized experiments : JoVE.

[71]  Erin Jackson,et al.  Cerenkov Radiation Energy Transfer (CRET) Imaging: A Novel Method for Optical Imaging of PET Isotopes in Biological Systems , 2010, PloS one.

[72]  S. Cherry,et al.  New covalent capture probes for imaging and therapy, based on a combination of binding affinity and disulfide bond formation. , 2011, Bioconjugate chemistry.

[73]  Johan Axelsson,et al.  Cerenkov emission induced by external beam radiation stimulates molecular fluorescence. , 2011, Medical physics.

[74]  David Gladstone.  Review article , 2005, Health Care Analysis.

[75]  Riccardo Calandrino,et al.  In vivo 18F-FDG tumour uptake measurements in small animals using Cerenkov radiation , 2010, European Journal of Nuclear Medicine and Molecular Imaging.

[76]  Zhen Cheng,et al.  Endoscopic imaging of Cerenkov luminescence , 2012, Biomedical optics express.

[77]  Scott C Davis,et al.  Oxygen tomography by Čerenkov-excited phosphorescence during external beam irradiation , 2013, Journal of biomedical optics.

[78]  N Suchowerska,et al.  Plastic scintillation dosimetry: comparison of three solutions for the Cerenkov challenge. , 2011, Physics in medicine and biology.

[79]  Jie Tian,et al.  Whole-Body Cerenkov Luminescence Tomography with the Finite Element SP3 Method , 2011, Annals of Biomedical Engineering.

[80]  A. Läuchli.  Radioassay for β-emitters in biological materials using cerenkov radiation , 1969 .

[81]  Paul Z Y Liu,et al.  Real-time scintillation array dosimetry for radiotherapy: the advantages of photomultiplier detectors. , 2012, Medical physics.

[82]  Zhen Cheng,et al.  Optical imaging of reporter gene expression using a positron-emission-tomography probe. , 2010, Journal of biomedical optics.

[83]  L. Johansson,et al.  Standardisation of (210)Pb by Čerenkov counting. , 2011, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[84]  Jimin Liang,et al.  Three-dimensional Noninvasive Monitoring Iodine-131 Uptake in the Thyroid Using a Modified Cerenkov Luminescence Tomography Approach , 2012, PloS one.

[85]  Sanjiv S. Gambhir,et al.  Molecular Optical Imaging with Radioactive Probes , 2010, PloS one.

[86]  Hans Tanke,et al.  Optical imaging as an expansion of nuclear medicine: Cerenkov-based luminescence vs fluorescence-based luminescence , 2013, European Journal of Nuclear Medicine and Molecular Imaging.