Evolved bayesian networks as a versatile alternative to partin tables for prostate cancer management

In this paper, we report on work done evolving Bayesian Networks with Genetic Algorithms. We use a Chain Model GA [19] to induce a Bayesian network model for the real world problem of Prostate Cancer management. Bayesian networks can and have been used in a wide range of complex domains, notably in medicine. In fact, they have shown powerful capabilities in representing and dealing with the uncertainties generally inherent in the clinical practice. In this study, we investigate those capabilities by testing the evolved model's predictive power and exploring its potential use as a more versatile alternative to the widely used Partin tables for prostate cancer pathology staging.

[1]  C. N. Liu,et al.  Approximating discrete probability distributions with dependence trees , 1968, IEEE Trans. Inf. Theory.

[2]  David Maxwell Chickering,et al.  Learning Equivalence Classes of Bayesian Network Structures , 1996, UAI.

[3]  E. Gamito,et al.  Artificial neural networks for predictive modeling in prostate cancer , 2004, Current oncology reports.

[4]  David Maxwell Chickering,et al.  Large-Sample Learning of Bayesian Networks is NP-Hard , 2002, J. Mach. Learn. Res..

[5]  Remco R. Bouckaert,et al.  Probalistic Network Construction Using the Minimum Description Length Principle , 1993, ECSQARU.

[6]  Nir Friedman,et al.  Learning Bayesian Networks with Local Structure , 1996, UAI.

[7]  David Heckerman,et al.  An empirical comparison of three inference methods , 2013, UAI.

[8]  John A. W. McCall,et al.  A chain-model genetic algorithm for Bayesian network structure learning , 2007, GECCO '07.

[9]  Tom Burr,et al.  Causation, Prediction, and Search , 2003, Technometrics.

[10]  Judea Pearl,et al.  Equivalence and Synthesis of Causal Models , 1990, UAI.

[11]  Kwong-Sak Leung,et al.  A Hybrid Data Mining Approach To Discover Bayesian Networks Using Evolutionary Programming , 2002, GECCO.

[12]  Gregory F. Cooper,et al.  A Bayesian method for the induction of probabilistic networks from data , 1992, Machine Learning.

[13]  L. Sobin,et al.  TNM Classification of Malignant Tumours , 1987, UICC International Union Against Cancer.

[14]  J. Huete,et al.  On the use of independence relationships for learning simplified belief networks , 1997 .

[15]  Eduard J. Gamito,et al.  Chapter 18 – Artificial Neural Networks for Predictive Modeling in Prostate Cancer , 2003 .

[16]  Pedro Larrañaga,et al.  Learning Bayesian network structures by searching for the best ordering with genetic algorithms , 1996, IEEE Trans. Syst. Man Cybern. Part A.

[17]  Zhen Zhang,et al.  Neural network based systems for prostate cancer stage prediction , 2000, Proceedings of the IEEE-INNS-ENNS International Joint Conference on Neural Networks. IJCNN 2000. Neural Computing: New Challenges and Perspectives for the New Millennium.

[18]  A W Partin,et al.  Combination of prostate-specific antigen, clinical stage, and Gleason score to predict pathological stage of localized prostate cancer. A multi-institutional update. , 1997, JAMA.

[19]  David J. Spiegelhalter,et al.  Probabilistic Networks and Expert Systems , 1999, Information Science and Statistics.

[20]  D. Chan,et al.  The use of prostate specific antigen, clinical stage and Gleason score to predict pathological stage in men with localized prostate cancer. , 1993, The Journal of urology.

[21]  Wray L. Buntine Operations for Learning with Graphical Models , 1994, J. Artif. Intell. Res..

[22]  Luis M. de Campos,et al.  On the use of independence relationships for learning simplified belief networks , 1997, Int. J. Intell. Syst..

[23]  David Maxwell Chickering,et al.  Learning Bayesian Networks: The Combination of Knowledge and Statistical Data , 1994, Machine Learning.

[24]  F. Harary New directions in the theory of graphs , 1973 .

[25]  Mesut Remzi,et al.  Novel artificial neural network for early detection of prostate cancer. , 2002, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[26]  Dirk Thierens,et al.  Building a GA from Design Principles for Learning Bayesian Networks , 2003, GECCO.

[27]  Jérôme Habrant,et al.  Structure Learning of Bayesian Networks from Databases by Genetic Algorithms-Application to Time Series Prediction in Finance , 1999, ICEIS.

[28]  Mikko Koivisto,et al.  Exact Bayesian Structure Discovery in Bayesian Networks , 2004, J. Mach. Learn. Res..

[29]  Stephen Connolly,et al.  Fast Facts: Prostate Cancer , 2009 .

[30]  Nir Friedman,et al.  Discretizing Continuous Attributes While Learning Bayesian Networks , 1996, ICML.