Selective Phosphorylation of South and North-Cytidine and Adenosine Methanocarba-Nucleosides by Human Nucleoside and Nucleotide Kinases Correlates with Their Growth Inhibitory Effects on Cultured Cells
暂无分享,去创建一个
[1] K. Jagarlamudi,et al. Quaternary structures of recombinant, cellular, and serum forms of Thymidine Kinase 1 from dogs and humans , 2012, BMC Biochemistry.
[2] S. Yao,et al. Influence of Sugar Ring Conformation on the Transportability of Nucleosides by Human Nucleoside Transporters , 2011, Chembiochem : a European journal of chemical biology.
[3] M. Konrad,et al. Post-translational phosphorylation of serine 74 of human deoxycytidine kinase favors the enzyme adopting the open conformation making it competent for nucleoside binding and release. , 2011, Biochemistry.
[4] L. Marnett,et al. Selective modulation of DNA polymerase activity by fixed-conformation nucleoside analogues. , 2010, Angewandte Chemie.
[5] C. George,et al. Synthesis, Conformational Analysis, and Biological Activity of a Rigid Carbocyclic Analogue of 2′‐Deoxyaristeromycin Built on a Bicyclo(3.1.0) hexane Template. , 2010 .
[6] S. Eriksson,et al. Identification and Characterization of Mitochondrial Factors Modulating Thymidine Kinase 2 Activity , 2010, Nucleosides, nucleotides & nucleic acids.
[7] J. Janin,et al. Human and viral nucleoside/nucleotide kinases involved in antiviral drug activation: structural and catalytic properties. , 2010, Antiviral research.
[8] R. Wolfenden,et al. Contrasting Behavior of Conformationally Locked Carbocyclic Nucleosides of Adenosine and Cytidine as Substrates for Deaminases , 2009, Nucleosides, nucleotides & nucleic acids.
[9] R. Bago,et al. Subcellular localization of Nm23/NDPK A and B isoforms: a reflection of their biological function? , 2009, Molecular and Cellular Biochemistry.
[10] M. Konrad,et al. Extending thymidine kinase activity to the catalytic repertoire of human deoxycytidine kinase. , 2009, Biochemistry.
[11] S. Eriksson,et al. Mechanisms of substrate selectivity for Bacillus anthracis thymidylate kinase , 2008, Protein science : a publication of the Protein Society.
[12] Da-wei Lin,et al. Identification of a putative human mitochondrial thymidine monophosphate kinase associated with monocytic/macrophage terminal differentiation , 2008, Genes to cells : devoted to molecular & cellular mechanisms.
[13] M. Konrad,et al. Elucidation of different binding modes of purine nucleosides to human deoxycytidine kinase. , 2008, Journal of medicinal chemistry.
[14] L. Delbaere,et al. Histidine phosphorylation in biological systems. , 2008, Biochimica et biophysica acta.
[15] M. Konrad,et al. Nonenantioselectivity property of human deoxycytidine kinase explained by structures of the enzyme in complex with L- and D-nucleosides. , 2007, Journal of medicinal chemistry.
[16] S. Hughes,et al. The history of N-methanocarbathymidine: the investigation of a conformational concept leads to the discovery of a potent and selective nucleoside antiviral agent. , 2006, Antiviral research.
[17] C. George,et al. Understanding how the herpes thymidine kinase orchestrates optimal sugar and nucleobase conformations to accommodate its substrate at the active site: a chemical approach. , 2005, Journal of the American Chemical Society.
[18] P. Boyer,et al. Fixed conformation nucleoside analogs effectively inhibit excision-proficient HIV-1 reverse transcriptases. , 2005, Journal of molecular biology.
[19] S. Eriksson,et al. Human deoxycytidine kinase as a deoxyribonucleoside phosphorylase. , 2004, Journal of molecular biology.
[20] V. Marquez. Chemical and biological consequences of locking the conformation of nucleosides at the two antipodal extremes of the pseudorotational cycle. , 2004, Nucleic acids symposium series.
[21] G. Schulz,et al. Biochemical and Structural Characterization of (South)-Methanocarbathymidine That Specifically Inhibits Growth of Herpes Simplex Virus Type 1 Thymidine Kinase-transduced Osteosarcoma Cells* , 2004, Journal of Biological Chemistry.
[22] Marc C Nicklaus,et al. Experimental and structural evidence that herpes 1 kinase and cellular DNA polymerase(s) discriminate on the basis of sugar pucker. , 2004, Journal of the American Chemical Society.
[23] K. Johansson,et al. Structure and function of cellular deoxyribonucleoside kinases , 2002, Cellular and Molecular Life Sciences CMLS.
[24] W. Lam,et al. Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates. , 2002, Cancer research.
[25] H. Munier-Lehmann,et al. Sugar specificity of bacterial CMP kinases as revealed by crystal structures and mutagenesis of Escherichia coli enzyme. , 2002, Journal of molecular biology.
[26] J. Janin,et al. Nucleoside-diphosphate kinase: structural and kinetic analysis of reaction pathway and phosphohistidine intermediate. , 2002, Methods in enzymology.
[27] K. Jacobson,et al. Synthesis and purine receptor affinity of 6-oxopurine nucleosides and nucleotides containing (N)-methanocarba-pseudoribose rings. , 2001, Bioorganic & medicinal chemistry letters.
[28] H. Eklund,et al. Structural basis for substrate specificities of cellular deoxyribonucleoside kinases , 2001, Nature Structural Biology.
[29] K. Jacobson,et al. Ring-Constrained (N)-methanocarba nucleosides as adenosine receptor agonists: independent 5'-uronamide and 2'-deoxy modifications. , 2001, Bioorganic & medicinal chemistry letters.
[30] A. Karlsson,et al. Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases. , 2001, Molecular pharmacology.
[31] S. Eriksson,et al. THE NMR CONFORMATION STUDY OF THE COMPLEXES OF DEOXYCYTIDINE KINASE (dCK) AND 2′-DEOXYCYTIDINE/2′-DEOXYADENOSINE , 2001, Nucleosides, Nucleotides & Nucleic Acids.
[32] Alexander D. MacKerell,et al. Use of oligodeoxyribonucleotides with conformationally constrained abasic sugar targets to probe the mechanism of base flipping by HhaI DNA (cytosine C5)-methyltransferase , 2000 .
[33] S. Eriksson,et al. Cloning and characterization of full-length mouse thymidine kinase 2: the N-terminal sequence directs import of the precursor protein into mitochondria. , 2000, The Biochemical journal.
[34] G. Schulz,et al. Kinetics and crystal structure of the wild-type and the engineered Y101F mutant of Herpes simplex virus type 1 thymidine kinase interacting with (North)-methanocarba-thymidine. , 2000, Biochemistry.
[35] K. Jacobson,et al. Methanocarba analogues of purine nucleosides as potent and selective adenosine receptor agonists. , 2000, Journal of medicinal chemistry.
[36] M. Nicklaus,et al. Adenosine deaminase prefers a distinct sugar ring conformation for binding and catalysis: kinetic and structural studies. , 2000, Biochemistry.
[37] D. Choudhury,et al. Stereoisomeric selectivity of human deoxyribonucleoside kinases. , 1999, Biochemistry.
[38] A. Karlsson,et al. Phosphorylation of deoxycytidine analog monophosphates by UMP-CMP kinase: molecular characterization of the human enzyme. , 1999, Molecular pharmacology.
[39] C. George,et al. Conformationally restricted nucleosides. The reaction of adenosine deaminase with substrates built on a bicyclo[3.1.0]hexane template. , 1999, Nucleosides & nucleotides.
[40] Victor E. Marquez,et al. HIV-1 REVERSE TRANSCRIPTASE CAN DISCRIMINATE BETWEEN TWO CONFORMATIONALLY LOCKED CARBOCYCLIC AZT TRIPHOSPHATE ANALOGUES , 1998 .
[41] S. Eriksson,et al. Substrate specificity of human recombinant mitochondrial deoxyguanosine kinase with cytostatic and antiviral purine and pyrimidine analogs. , 1998, Molecular pharmacology.
[42] V. Marquez,et al. Conformationally Locked Carbocyclic Nucleosides Built on a Bicyclo(3.1. 0)hexane Template with a Fixed Southern Conformation. Synthesis and Antiviral Activity. , 1997 .
[43] C. George,et al. Conformational Analysis of Nucleosides Constructed on a Bicyclo[3.1.0]hexane Template. Structure-Antiviral Activity Analysis for the Northern and Southern Hemispheres of the Pseudorotational Cycle , 1997 .
[44] V. Marquez,et al. Conformationally locked carbocyclic nucleosides built on abicyclo[3.1.0]hexane template with a fixed Southern conformation.Synthesis and antiviral activity , 1997 .
[45] U. Hellman,et al. Cloning and expression of human mitochondrial deoxyguanosine kinase cDNA , 1996, FEBS letters.
[46] C. George,et al. Synthesis, Conformational Analysis, and Biological Activity of a Rigid Carbocyclic Analogue of 2′-Deoxy Aristeromycin Built on a Bicyclo[3.1.0]hexane Template # , 1996 .
[47] R. Wagner,et al. Nucleosides with a twist. Can fixed forms of sugar ring pucker influence biological activity in nucleosides and oligonucleotides? , 1996, Journal of Medicinal Chemistry.
[48] K. Altmann,et al. 1′,6′-methano carbocyclic thymidine: Synthesis, x-ray crystal structure, and effect on nucleic acid duplex stability , 1994 .
[49] K. Altmann,et al. 4′,6′-Methano carbocyclic thymidine: A conformationally constrained building block for oligonucleotides , 1994 .
[50] B. Oberg,et al. Comparison of the substrate specificities of human thymidine kinase 1 and 2 and deoxycytidine kinase toward antiviral and cytostatic nucleoside analogs. , 1991, Biochemical and biophysical research communications.
[51] R. Schinazi,et al. Correlation of Molecular Conformation and Activity of Reverse Transcriptase Inhibitors a , 1990, Annals of the New York Academy of Sciences.
[52] W. Saenger. Structures and Conformational Properties of Bases, Furanose Sugars, and Phosphate Groups , 1984 .
[53] U. Maitra,et al. Association of a GDP binding activity with initiation factor eIF-2 from calf liver. , 1977, Biochemical and biophysical research communications.
[54] W. Cleland,et al. Kinetic studies of yeast nucleoside diphosphate kinase. , 1969, Biochemistry.