Does neuroprotection improve stroke outcome?

conjugate vaccine to the South American market. This competition may be all that is required to bring the price there within reach. Policymakers should, however, be made aware of the high value of vaccination. Even if a new vaccine is considerably more costly, its costeffectiveness in a particular country may be almost unparalleled as a medical intervention. Sadly, even inexpensive routine childhood vaccines (eg, against diphtheria, tetanus, and pertussis) are affordable in some poorer African countries only because of the special arrangement whereby UNICEF, in collaboration with WHO, purchases high volumes at substantially reduced cost from non-US vaccine manufacturers that adopt a two-tiered pricing policy. Thus richer countries are effectively subsidising those less able to pay. Lately, US manufacturers have reportedly been taking steps to have some of their vaccines certified by WHO. Perhaps President Clinton’s recent catch-cry in Africa, “trade not aid”, can be reversed in respect of life-saving vaccines.

[1]  Multicentre Acute Stroke Trial—Italy Group Randomised controlled trial of streptokinase, aspirin, and combination of both in treatment of acute ischaemic stroke , 1995, The Lancet.

[2]  G. Hankey,et al.  Trials of streptokinase in severe acute ischaemic stroke , 1995, The Lancet.

[3]  J. Grotta,et al.  Lubeluzole in Acute Ischemic Stroke Treatment , 2000 .

[4]  K. Lees,et al.  Clinical experience with excitatory amino acid antagonist drugs. , 1995, Stroke.

[5]  H. Diener Multinational Randomised Controlled Trial of Lubeluzole in Acute Ischaemic Stroke , 1998, Cerebrovascular Diseases.

[6]  C. Cantú,et al.  Cerebral Infarction in PeopleUnder 40 YearsI , 1996 .

[7]  Caroline Leigh Watkins The International Stroke Trial (IST): a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19 435 patients with acute ischaemic stroke , 1997 .

[8]  J. Grotta Lubeluzole treatment of acute ischemic stroke. The US and Canadian Lubeluzole Ischemic Stroke Study Group. , 1997, Stroke.

[9]  L. Munari,et al.  RANDOMIZED CONTROLLED TRIAL OF STREPTOKINASE, ASPIRIN, AND COMBINATION OF BOTH IN TREATMENT OF ACUTE ISCHEMIC STROKE , 1995 .

[10]  M. Dennis,et al.  Should stroke medicine be a separate subspecialty? , 1997 .

[11]  Peter Sandercock,et al.  The International Stroke Trial (IST): a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19 435 patients with acute ischaemic stroke , 1997, The Lancet.

[12]  Joseph P. Broderick,et al.  Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. , 1995 .

[13]  H. Diener,et al.  Termination of Acute Stroke Studies Involving Selfotel Treatment , 1997, The Lancet.

[14]  C. Warlow,et al.  Systematic review of evidence on thrombolytic therapy for acute ischaemic stroke , 1997, The Lancet.

[15]  Joakim Bjorkdahl Is hyperglycaemia an independent predictor of poor outcome after acute stroke? Results of a long term follow up study: , 1997 .

[16]  Koroshetz Wj,et al.  Tissue plasminogen activator for acute ischemic stroke. , 1996, The New England journal of medicine.

[17]  Langhorne,et al.  Collaborative systematic review of the randomised trials of organised inpatient (stroke unit) care after stroke , 1997, BMJ.

[18]  O. Rønning,et al.  Stroke units versus general medical wards, I: twelve- and eighteen-month survival: a randomized, controlled trial. , 1998, Stroke.

[19]  M. Hommel,et al.  Thrombolytic therapy with streptokinase in acute ischemic stroke. , 1996, The New England journal of medicine.

[20]  K. Lees,et al.  A randomized, double-blind, placebo-controlled pilot trial of intravenous magnesium sulfate in acute stroke. , 1995, Stroke.

[21]  H. Diener,et al.  Lubeluzole in acute ischemic stroke. A double-blind, placebo-controlled phase II trial. Lubeluzole International Study Group. , 1996, Stroke.