Spinal cord stimulation for neuropathic pain: current perspectives

Neuropathic pain constitutes a significant portion of chronic pain. Patients with neuropathic pain are usually more heavily burdened than patients with nociceptive pain. They suffer more often from insomnia, anxiety, and depression. Moreover, analgesic medication often has an insufficient effect on neuropathic pain. Spinal cord stimulation constitutes a therapy alternative that, to date, remains underused. In the last 10 to 15 years, it has undergone constant technical advancement. This review gives an overview of the present practice of spinal cord stimulation for chronic neuropathic pain and current developments such as high-frequency stimulation and peripheral nerve field stimulation.

[1]  塚原 徹也,et al.  Dorsal Column Stimulation for Control of Pain , 1980 .

[2]  Krishna Kumar,et al.  Spinal Cord Stimulation in Treatment of Chronic Benign Pain: Challenges in Treatment Planning and Present Status, a 22-Year Experience , 2006, Neurosurgery.

[3]  H. Birnbaum,et al.  The prevalence and economic impact of prescription opioid-related side effects among patients with chronic noncancer pain. , 2013, Journal of Opioid Management.

[4]  H C de Vet,et al.  Spinal cord stimulation in patients with chronic reflex sympathetic dystrophy. , 2000, The New England journal of medicine.

[5]  D. Vivian,et al.  Peripheral nerve field stimulation for chronic pain: 100 cases and review of the literature. , 2011, Pain medicine.

[6]  M. van Kleef,et al.  Electrical spinal cord stimulation in painful diabetic polyneuropathy, a systematic review on treatment efficacy and safety. , 2011, European journal of pain.

[7]  S. Palmisani,et al.  Sustained Effectiveness of 10 kHz High-Frequency Spinal Cord Stimulation for Patients with Chronic, Low Back Pain: 24-Month Results of a Prospective Multicenter Study , 2013, Pain medicine.

[8]  G. Barolat,et al.  Spinal Cord Stimulation (SCS) in Conjunction With Peripheral Nerve Field Stimulation (PNfS) for the Treatment of Complex Pain in Failed Back Surgery Syndrome (FBSS) , 2013, Neuromodulation : journal of the International Neuromodulation Society.

[9]  R. Baron,et al.  painDETECT: a new screening questionnaire to identify neuropathic components in patients with back pain , 2006, Current medical research and opinion.

[10]  T. Wolter,et al.  The impact of psychological factors on outcomes for spinal cord stimulation: an analysis with long-term follow-up. , 2013, Pain physician.

[11]  T. Stitik Spine Surgery: Techniques, Complication Avoidance, and Management , 1999 .

[12]  J. Schoenen,et al.  Occipital nerve stimulation for drug-resistant chronic cluster headache: a prospective pilot study , 2007, The Lancet Neurology.

[13]  J. Berger,et al.  Cross talk: a new method for peripheral nerve stimulation. An observational report with cadaveric verification. , 2009, Pain physician.

[14]  M. Meglio,et al.  Spinal cord stimulation in management of chronic pain. A 9-year experience. , 1989, Journal of neurosurgery.

[15]  V. Yakovleva,et al.  Peripheral Nerve Field Stimulation in the Treatment of Postlaminectomy Syndrome after Multilevel Spinal Surgeries , 2011, Neuromodulation : journal of the International Neuromodulation Society.

[16]  M. Gierthmuehlen,et al.  Spinal cord stimulation inhibits cortical somatosensory evoked potentials significantly stronger than transcutaneous electrical nerve stimulation. , 2013, Pain physician.

[17]  L. Watkins,et al.  Treatment of medically intractable cluster headache by occipital nerve stimulation: long-term follow-up of eight patients , 2007, The Lancet.

[18]  S. Jabbur,et al.  Inhibitory effects from various types of dorsal column and raphe magnus stimulations on nociceptive withdrawal flexion reflexes , 1999, Brain Research.

[19]  H. Kaube,et al.  Effects of sub‐perception threshold spinal cord stimulation in neuropathic pain: A randomized controlled double‐blind crossover study , 2012, European journal of pain.

[20]  J. Swett,et al.  Retrospective analysis of 22 patients with chronic pain treated by peripheral nerve stimulation. , 1980, Journal of neurosurgery.

[21]  K J Burchiel,et al.  Prospective, Multicenter Study of Spinal Cord Stimulation for Relief of Chronic Back and Extremity Pain , 1996, Spine.

[22]  Krishna Kumar,et al.  Cost-effectiveness of spinal cord stimulation therapy in management of chronic pain. , 2013, Pain medicine.

[23]  H. Harke,et al.  Spinal cord stimulation in sympathetically maintained complex regional pain syndrome type I with severe disability. A prospective clinical study , 2005, European journal of pain.

[24]  S. Piantadosi,et al.  Spinal cord stimulation versus reoperation for failed back surgery syndrome: a prospective, randomized study design. , 1995, Acta neurochirurgica. Supplement.

[25]  M. Tatagiba,et al.  Combined Spinal Cord and Peripheral Nerve Field Stimulation for Persistent Post‐Herniorrhaphy Pain , 2013, Neuromodulation : journal of the International Neuromodulation Society.

[26]  Bengt Linderoth,et al.  Spinal cord stimulation attenuates augmented dorsal horn release of excitatory amino acids in mononeuropathy via a GABAergic mechanism , 1997, Pain.

[27]  Clark C Smith,et al.  A report of paraparesis following spinal cord stimulator trial, implantation and revision. , 2010, Pain physician.

[28]  G. Somjen,et al.  Paresthesias and EEG potentials evoked by stimulation of the dorsal funiculi in man. , 1972, Experimental neurology.

[29]  S. Bhatnagar,et al.  Peripheral Nerve Field Stimulation for Intractable Post‐Thoracotomy Scar Pain not Relieved by Conventional Treatment , 2010, Pain practice : the official journal of World Institute of Pain.

[30]  R. Paicius,et al.  Peripheral Nerve Field Stimulation for the Treatment of Chronic Low Back Pain: Preliminary Results of Long‐Term Follow‐up: A Case Series , 2007, Neuromodulation : journal of the International Neuromodulation Society.

[31]  G. Messina,et al.  Spinal cord stimulation for recurrent painful neuromas of the foot , 2011, Neurological Sciences.

[32]  W. Collins,et al.  Partial, reversible, functional spinal cord transection. A complication of dorsal column stimulation for the relief of pain. , 1974, Archives of neurology.

[33]  J. Krainick,et al.  Experience with dorsal column stimulation (DCS) in the operative treatment of chronic intractable pain. , 1974, Journal of neurosurgical sciences.

[34]  R. Patterson,et al.  Delayed intraspinal hemorrhage after dorsal column stimulation for pain. , 1974, Archives of neurology.

[35]  J. Mortimer,et al.  electrical inhibition of pain: experimental evaluation* , 1967, Anesthesia and analgesia.

[36]  R. Taylor Spinal cord stimulation in complex regional pain syndrome and refractory neuropathic back and leg pain/failed back surgery syndrome: results of a systematic review and meta-analysis. , 2006, Journal of pain and symptom management.

[37]  T. Simopoulos,et al.  Spinal cord stimulation for the treatment of chronic knee pain following total knee replacement. , 2010, Pain physician.

[38]  Peter Kosek,et al.  Sensor-driven position-adaptive spinal cord stimulation for chronic pain. , 2012, Pain physician.

[39]  Steven P. Cohen,et al.  Spinal cord stimulation for severe degenerative joint disease of the shoulder in a patient with severe chronic obstructive pulmonary disease: a new indication? , 2010, Anesthesia and analgesia.

[40]  M. van Kleef,et al.  The effect of spinal cord stimulation in patients with chronic reflex sympathetic dystrophy: Two years' follow‐up of the randomized controlled trial , 2004, Annals of neurology.

[41]  G. Broggi,et al.  Italian multicentric study on pain treatment with epidural spinal cord stimulation. , 1994, Stereotactic and functional neurosurgery.

[42]  K. Aló,et al.  Effects of Posture on Stimulation Parameters in Spinal Cord Stimulation , 1998, Neuromodulation : journal of the International Neuromodulation Society.

[43]  A. Patil,et al.  Peripheral Nerve Field Stimulation for Sacroiliac Joint Pain , 2014, Neuromodulation : journal of the International Neuromodulation Society.

[44]  M. van Kleef,et al.  Effect of spinal cord stimulation for chronic complex regional pain syndrome Type I: five-year final follow-up of patients in a randomized controlled trial. , 2008, Journal of neurosurgery.

[45]  M. Baliki,et al.  Attenuation of neuropathic pain by segmental and supraspinal activation of the dorsal column system in awake rats , 2002, Neuroscience.

[46]  J. Henderson,et al.  Failure modes of spinal cord stimulation hardware. , 2006, Journal of neurosurgery. Spine.

[47]  J Holsheimer,et al.  MR assessment of the normal position of the spinal cord in the spinal canal. , 1994, AJNR. American journal of neuroradiology.

[48]  P. Wall,et al.  Pain mechanisms: a new theory. , 1965, Science.

[49]  Y. Hosobuchi,et al.  Preliminary percutaneous dorsal column stimulation prior to permanent implantation. Technical note. , 1972, Journal of neurosurgery.

[50]  M. Ifuku,et al.  Efficacy of limited-duration spinal cord stimulation for subacute postherpetic neuralgia. , 2009, Annals of the Academy of Medicine, Singapore.

[51]  A. Burkey,et al.  Successful treatment of central pain in a multiple sclerosis patient with epidural stimulation of the dorsal root entry zone. , 2010, Pain medicine.

[52]  T. Wolter,et al.  Continuous Versus Intermittent Spinal Cord Stimulation: An Analysis of Factors Influencing Clinical Efficacy , 2012, Neuromodulation : journal of the International Neuromodulation Society.

[53]  L. Watkins,et al.  Treatment of intractable chronic cluster headache by occipital nerve stimulation in 14 patients , 2009, Neurology.

[54]  Matthew W. Doust,et al.  Subcutaneous Peripheral Nerve Stimulation with Inter‐lead Stimulation for Axial Neck and Low Back Pain: Case Series and Review of the Literature , 2012, Neuromodulation : journal of the International Neuromodulation Society.

[55]  H. Kawai,et al.  Late onset cervical myelopathy secondary to fibrous scar tissue formation around the spinal cord stimulation electrode , 2010, Spinal Cord.

[56]  B. Linderoth,et al.  “The failed back surgery syndrome”: Definition and therapeutic algorithms — An update , 2010 .

[57]  Edward C. Benzel,et al.  Spine Surgery: Techniques, Complication Avoidance and Management , 1998 .

[58]  J. R. Wilson,et al.  Factors affecting spinal cord stimulation outcome in chronic benign pain with suggestions to improve success rate. , 2007, Acta neurochirurgica. Supplement.

[59]  D. Abejón,et al.  Is impedance a parameter to be taken into account in spinal cord stimulation? , 2007, Pain physician.

[60]  G. Barolat,et al.  Pain and Spasticity , 2005 .

[61]  J. Schoenen,et al.  Sustained Effectiveness of Occipital Nerve Stimulation in Drug‐Resistant Chronic Cluster Headache , 2011, Headache.

[62]  G. Barolat,et al.  Multifactorial analysis of epidural spinal cord stimulation. , 1991, Stereotactic and functional neurosurgery.

[63]  R. North,et al.  Postural Changes in Spinal Cord Stimulation Perceptual Thresholds , 1998, Neuromodulation : journal of the International Neuromodulation Society.

[64]  V. Tronnier,et al.  Subkutane periphere Stimulation des N. occipitalis major zur Behandlung chronischer Kopfschmerzsyndrome , 2010, Der Schmerz.

[65]  J. Mortimer,et al.  Electrical Inhibition of Pain by Stimulation of the Dorsal Columns: Preliminary Clinical Report , 1967, Anesthesia and analgesia.

[66]  G. Barolat Peripheral subcutaneous stimulation for intractable abdominal pain. , 2011, Progress in neurological surgery.

[67]  W T O'Connor,et al.  Release of gamma-aminobutyric acid in the dorsal horn and suppression of tactile allodynia by spinal cord stimulation in mononeuropathic rats. , 1996, Neurosurgery.

[68]  Bengt Linderoth,et al.  Spinal cord stimulation: exploration of the physiological basis of a widely used therapy. , 2010, Anesthesiology.

[69]  V. Tronnier,et al.  [Subcutaneous peripheral stimulation of the greater occipital nerve for the treatment of chronic headache syndromes]. , 2010, Schmerz.

[70]  H. Binder,et al.  Peripheral Nerve Field Stimulation (PNFS) in Chronic Low Back Pain: A Prospective Multicenter Study , 2014, Neuromodulation : journal of the International Neuromodulation Society.

[71]  S. Palmisani,et al.  High‐Frequency Spinal Cord Stimulation for the Treatment of Chronic Back Pain Patients: Results of a Prospective Multicenter European Clinical Study , 2013, Neuromodulation : journal of the International Neuromodulation Society.

[72]  M. Pinter,et al.  Subcutaneous Target Stimulation (STS) in Chronic Noncancer Pain: A Nationwide Retrospective Study , 2010, Pain practice : the official journal of World Institute of Pain.

[73]  R. Taylor,et al.  Impact of the National Institute for Health and Care Excellence (NICE) guidance on medical technology uptake: analysis of the uptake of spinal cord stimulation in England 2008–2012 , 2014, BMJ Open.

[74]  S. Jabbur,et al.  Spinal segmental and supraspinal mechanisms underlying the pain-relieving effects of spinal cord stimulation: An experimental study in a rat model of neuropathy , 2012, Neuroscience.

[75]  C. Dirksen,et al.  Sustained effect of spinal cord stimulation on pain and quality of life in painful diabetic peripheral neuropathy. , 2013, British journal of anaesthesia.

[76]  Kazuhide Moriyama Effect of Temporary Spinal Cord Stimulation on Postherpetic Neuralgia in the Thoracic Nerve Area , 2009, Neuromodulation : journal of the International Neuromodulation Society.

[77]  M. Boakye,et al.  Outcomes of Percutaneous and Paddle Lead Implantation for Spinal Cord Stimulation: A Comparative Analysis of Complications, Reoperation Rates, and Health‐Care Costs , 2013, Neuromodulation : journal of the International Neuromodulation Society.

[78]  Marc Russo,et al.  Stimulation of Dorsal Root Ganglia for the Management of Complex Regional Pain Syndrome: A Prospective Case Series , 2015, Pain practice : the official journal of World Institute of Pain.

[79]  T. Menovsky,et al.  Burst Spinal Cord Stimulation: Toward Paresthesia‐Free Pain Suppression , 2010, Neurosurgery.

[80]  R. Weiner,et al.  Peripheral Neurostimulation to Control Intractable Occipital Neuralgia , 1999 .

[81]  C N Shealy,et al.  Dorsal column electroanalgesia. , 1970, Journal of neurosurgery.

[82]  N. B. Finnerupa,et al.  Algorithm for neuropathic pain treatment: An evidence based proposal , 2005 .

[83]  Shealy Cn,et al.  Electrical inhibition of pain by stimulation of the dorsal columns: preliminary clinical report. , 1967 .

[84]  J. Krauss,et al.  Cervical Myelopathy due to an Epidural Cervical Mass after Chronic Cervical Spinal Cord Stimulation , 2013, Stereotactic and Functional Neurosurgery.

[85]  Jianguo Cheng,et al.  Retrospective Review of 707 Cases of Spinal Cord Stimulation: Indications and Complications , 2011, Pain practice : the official journal of World Institute of Pain.

[86]  F. Guillén,et al.  Spinal Cord Compression From a Foreign Body Reaction to Spinal Cord Stimulation: A Previously Unreported Complication , 2010, Spine.

[87]  P. Lynch,et al.  An Innovative Case Report Detailing the Successful Treatment of Post‐Thoracotomy Syndrome with Peripheral Nerve Field Stimulation , 2010, Neuromodulation : journal of the International Neuromodulation Society.

[88]  S. Jabbur,et al.  Supraspinal modulation of nociception in awake rats by stimulation of the dorsal column nuclei , 1986, Brain Research.

[89]  T. Goroszeniuk,et al.  Subcutaneous Neuromodulating Implant Targeted at the Site of Pain , 2006, Regional Anesthesia & Pain Medicine.

[90]  Bengt Linderoth,et al.  Effects of spinal cord stimulation on touch-evoked allodynia involve GABAergic mechanisms. An experimental study in the mononeuropathic rat , 1996, PAIN®.

[91]  B. Nashold,et al.  Dorsal column stimulation for control of pain. Preliminary report on 30 patients. , 1972, Journal of neurosurgery.

[92]  E. Buchser,et al.  Spinal Cord Stimulation for Chronic Back and Leg Pain and Failed Back Surgery Syndrome: A Systematic Review and Analysis of Prognostic Factors , 2005, Spine.

[93]  M. van Kleef,et al.  Spinal cord stimulation for chronic reflex sympathetic dystrophy--five-year follow-up. , 2006, The New England journal of medicine.

[94]  Y. E. Mironer,et al.  Prospective, Two‐part Study of the Interaction Between Spinal Cord Stimulation and Peripheral Nerve Field Stimulation in Patients with Low Back Pain: Development of a New Spinal‐Peripheral Neurostimulation Method , 2011, Neuromodulation : journal of the International Neuromodulation Society.

[95]  E. Buchser,et al.  Spinal cord stimulation versus conventional medical management for neuropathic pain: A multicentre randomised controlled trial in patients with failed back surgery syndrome , 2007, Pain.

[96]  J. D'haese,et al.  Spinal cord stimulation as a treatment for refractory neuropathic pain in tethered cord syndrome: a case report , 2010, Journal of medical case reports.

[97]  J Holsheimer,et al.  Significance of the spinal cord position in spinal cord stimulation. , 1995, Acta neurochirurgica. Supplement.

[98]  F. Oppel,et al.  [Peripheral nerve stimulation for pain relief in CRPS II and phantom-limb pain]. , 1999, Schmerz.

[99]  E. Sparkes,et al.  A systematic literature review of psychological characteristics as determinants of outcome for spinal cord stimulation therapy , 2010, PAIN.

[100]  Kevin L Wininger,et al.  Spinal cord stimulation to treat postthoracotomy neuralgia: non-small-cell lung cancer: a case report. , 2012, Pain management nursing : official journal of the American Society of Pain Management Nurses.

[101]  Bengt Linderoth,et al.  Cholinergic mechanisms involved in the pain relieving effect of spinal cord stimulation in a model of neuropathy , 2008, PAIN.

[102]  S. Piantadosi,et al.  Spinal Cord Stimulation versus Repeated Lumbosacral Spine Surgery for Chronic Pain: A Randomized, Controlled Trial , 2005, Neurosurgery.

[103]  C. M. Schade,et al.  Automatic adaptation of neurostimulation therapy in response to changes in patient position: results of the Posture Responsive Spinal Cord Stimulation (PRS) Research Study. , 2011, Pain physician.

[104]  B. Meyerson,et al.  Muscarinic receptor activation potentiates the effect of spinal cord stimulation on pain-related behavior in rats with mononeuropathy , 2008, Neuroscience Letters.

[105]  M. Sculpher,et al.  Spinal Cord Stimulation vs. Conventional Medical Management: A Prospective, Randomized, Controlled, Multicenter Study of Patients with Failed Back Surgery Syndrome (PROCESS Study) , 2005, Neuromodulation : journal of the International Neuromodulation Society.

[106]  T. Deer,et al.  Spinal Cord Stimulation as Treatment for Complex Regional Pain Syndrome Should Be Considered Earlier Than Last Resort Therapy , 2013, Neuromodulation : journal of the International Neuromodulation Society.

[107]  R. Paicius,et al.  Peripheral nerve field stimulation in chronic abdominal pain. , 2006, Pain physician.

[108]  B. Meyerson,et al.  Pain relief by spinal cord stimulation involves serotonergic mechanisms: An experimental study in a rat model of mononeuropathy , 2009, PAIN®.

[109]  R. Paicius,et al.  Spinal Cord Stimulation in Conjunction With Peripheral Nerve Field Stimulation for the Treatment of Low Back and Leg Pain: A Case Series , 2008, Neuromodulation : journal of the International Neuromodulation Society.

[110]  I. Gültuna,et al.  Subcutaneous Stimulation as an Additional Therapy to Spinal Cord Stimulation for the Treatment of Lower Limb Pain and/or Back Pain: A Feasibility Study , 2012, Neuromodulation : journal of the International Neuromodulation Society.

[111]  Steven P. Cohen,et al.  Spinal cord stimulation for patients with failed back surgery syndrome: a systematic review. , 2009, Pain physician.

[112]  B. Schuknecht,et al.  Spinal magnetic resonance imaging with reduced specific absorption rate in patients harbouring a spinal cord stimulation device - A single-centre prospective study analysing safety, tolerability and image quality , 2013, Acta Neurochirurgica.

[113]  Bengt Linderoth,et al.  Spinal cord stimulation attenuates dorsal horn neuronal hyperexcitability in a rat model of mononeuropathy , 1999, PAIN.

[114]  Sven Vanneste,et al.  Burst spinal cord stimulation for limb and back pain. , 2013, World neurosurgery.

[115]  E. Lipov 'Hybrid neurostimulator': simultaneous use of spinal cord and peripheral nerve field stimulation to treat low back and leg pain. , 2011, Progress in neurological surgery.

[116]  D. Kewman,et al.  MMPI Indicators of Treatment Response to Spinal Epidural Stimulation in Patients with Chronic Pain and Patients with Movement Disorders , 1982, Psychological Reports.

[117]  T. Deer,et al.  A Prospective Study of Dorsal Root Ganglion Stimulation for the Relief of Chronic Pain , 2013, Neuromodulation : journal of the International Neuromodulation Society.

[118]  J. P. Johnson,et al.  Quadriparesis and Spinal Cord Stimulation: Case Report , 2007, Spine.

[119]  R. Nath,et al.  Spinal cord stimulation for chronic pain in peripheral neuropathy. , 1996, Surgical neurology.

[120]  G. Cosgrove,et al.  Spinal cord stimulation for treatment of meralgia paresthetica. , 2005, Pain physician.

[121]  Robert Levy,et al.  A Multicenter, Prospective Trial to Assess the Safety and Performance of the Spinal Modulation Dorsal Root Ganglion Neurostimulator System in the Treatment of Chronic Pain , 2013, Neuromodulation : journal of the International Neuromodulation Society.

[122]  R. North,et al.  A prospective, randomized study of spinal cord stimulation versus reoperation for failed back surgery syndrome: initial results. , 1994, Stereotactic and functional neurosurgery.

[123]  P. M. Munarriz,et al.  Dorsal myelopathy secondary to epidural fibrous scar tissue around a spinal cord stimulation electrode. , 2012, Journal of neurosurgery. Spine.

[124]  B. Quinio,et al.  Cervical cord compression due to delayed scarring around epidural electrodes used in spinal cord stimulation. , 2010, Journal of neurosurgery. Spine.

[125]  G. Barolat,et al.  Peripheral Nerve Field Stimulation for the Management of Localized Chronic Intractable Back Pain: Results From a Randomized Controlled Study , 2013, Neuromodulation (Malden, Mass.).

[126]  S. Tesfaye,et al.  Electrical spinal-cord stimulation for painful diabetic peripheral neuropathy , 1996, The Lancet.

[127]  R. Meyer,et al.  Spinal Cord Stimulation-induced Analgesia: Electrical Stimulation of Dorsal Column and Dorsal Roots Attenuates Dorsal Horn Neuronal Excitability in Neuropathic Rats , 2010, Anesthesiology.

[128]  Y. Katayama,et al.  Spinal Cord Stimulation for Neuropathic Pain , 2014 .

[129]  Krishna Kumar,et al.  Impact of Wait times on Spinal Cord Stimulation Therapy Outcomes , 2014, Pain practice : the official journal of World Institute of Pain.

[130]  T. Cameron,et al.  Safety and efficacy of spinal cord stimulation for the treatment of chronic pain: a 20-year literature review. , 2004, Journal of neurosurgery.

[131]  H. Harke,et al.  Spinal Cord Stimulation in Postherpetic Neuralgia and in Acute Herpes Zoster Pain , 2002, Anesthesia and analgesia.

[132]  E. Buchser,et al.  Analgesic Efficacy of High‐Frequency Spinal Cord Stimulation: A Randomized Double‐Blind Placebo‐Controlled Study , 2013, Neuromodulation : journal of the International Neuromodulation Society.