Sestrins inhibit mTORC1 kinase activation through the GATOR complex.
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Wei Wang | M. Karin | K. Guan | A. Budanov | Boxiao Ding | A. Parmigiani | Young Chul Kim | Aida Nourbakhsh | K. Akopiants
[1] Steven P Gygi,et al. The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1. , 2014, Cell reports.
[2] Ming O. Li,et al. Sestrins Function as Guanine Nucleotide Dissociation Inhibitors for Rag GTPases to Control mTORC1 Signaling , 2014, Cell.
[3] Seung Joong Kim,et al. Molecular Architecture and Function of the SEA Complex, a Modulator of the TORC1 Pathway* , 2014, Molecular & Cellular Proteomics.
[4] D. Sabatini,et al. Regulation of mTORC1 by amino acids. , 2014, Trends in cell biology.
[5] K. Guan,et al. Rag GTPases are cardioprotective by regulating lysosomal function , 2014, Nature Communications.
[6] L. Cantley,et al. Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome , 2014, Cell.
[7] Joseph Avruch,et al. Amino Acids Activate Mammalian Target of Rapamycin (mTOR) Complex 1 without Changing Rag GTPase Guanyl Nucleotide Charging , 2013, The Journal of Biological Chemistry.
[8] M. Karin,et al. Sestrins orchestrate cellular metabolism to attenuate aging. , 2013, Cell metabolism.
[9] B. Manning,et al. Signal integration by mTORC1 coordinates nutrient input with biosynthetic output , 2013, Nature Cell Biology.
[10] Matthew Meyerson,et al. A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1 , 2013, Science.
[11] I. Ben-Sahra,et al. Sestrin2 integrates Akt and mTOR signaling to protect cells against energetic stress-induced death , 2012, Cell Death and Differentiation.
[12] O. Kirak,et al. Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival , 2012, Nature.
[13] Hye Eun Lee,et al. Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage. , 2013, Cell metabolism.
[14] Mark Ellisman,et al. Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3. , 2012, Cell metabolism.
[15] D. Sabatini,et al. mTOR Signaling in Growth Control and Disease , 2012, Cell.
[16] D. Hardie,et al. AMPK: a nutrient and energy sensor that maintains energy homeostasis , 2012, Nature Reviews Molecular Cell Biology.
[17] A. Budanov. Stress-responsive sestrins link p53 with redox regulation and mammalian target of rapamycin signaling. , 2011, Antioxidants & redox signaling.
[18] R. Shaw,et al. The AMPK signalling pathway coordinates cell growth, autophagy and metabolism , 2011, Nature Cell Biology.
[19] Jinrong Min,et al. Structure and function of WD40 domain proteins , 2011, Protein & Cell.
[20] M. Karin,et al. Stressin' Sestrins take an aging fight , 2010, EMBO molecular medicine.
[21] B. Viollet,et al. Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner. , 2010, Cell metabolism.
[22] Mark H. Ellisman,et al. Sestrin as a Feedback Inhibitor of TOR That Prevents Age-Related Pathologies , 2010, Science.
[23] Michael Karin,et al. p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling , 2009, Cell.
[24] David M. Sabatini,et al. The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1 , 2008, Science.
[25] B. Turk,et al. AMPK phosphorylation of raptor mediates a metabolic checkpoint. , 2008, Molecular cell.
[26] G. Thomas,et al. mTOR Complex1-S6K1 signaling: at the crossroads of obesity, diabetes and cancer. , 2007, Trends in molecular medicine.
[27] M. Hall,et al. TOR Signaling in Growth and Metabolism , 2006, Cell.
[28] P. Chumakov,et al. The antioxidant function of the p53 tumor suppressor , 2005, Nature Medicine.
[29] N. Sonenberg,et al. Upstream and downstream of mTOR. , 2004, Genes & development.
[30] E. Koonin,et al. Regeneration of Peroxiredoxins by p53-Regulated Sestrins, Homologs of Bacterial AhpD , 2004, Science.
[31] K. Inoki,et al. TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival , 2003, Cell.
[32] A. Chajut,et al. Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability , 2002, Oncogene.
[33] A. Levine. p53, the Cellular Gatekeeper for Growth and Division , 1997, Cell.