Acetyl Chloride-Mediated Synthesis of trans-2-[(Diethoxyphosphorylamino)alkyl]-4-aryl-5,5-dimethyl-1,3,2λ5-dioxaphosphorinane-2-oxide

N-Phosphoramino-protected six-membered cyclic α-aminophosphonates trans-2-[(diethoxyphosphorylamino)-alkyl]-4-aryl-5,5-dimethyl-1,3,2,λ 5 -dioxaphosphorinane-2-oxide 4a-41 were synthesized with the help of acetyl chloride. 31 PNMR was used to trace the reaction process. A possible reaction mechanism was proposed and the stereochemistry of the title compounds was studied. In order to confirm the structure of 4, products 4f and 4k were recrystallized and determined by X-ray diffraction analysis.

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