Restricting cough and cold medicines in children

Aims:  Based on concerns about safety and efficacy, international authorities have either advised against the use of cough and cold medication or considering such action. We aimed to systematically review the evidence for the effectiveness and safety of cough and cold medicines in children.

[1]  A. Alkan,et al.  Prescribing practices of physicians at different health care institutions. , 2013, The Eurasian journal of medicine.

[2]  T. Lion,et al.  Lessons learned from a double-blind randomised placebo-controlled study with a iota-carrageenan nasal spray as medical device in children with acute symptoms of common cold , 2012, BMC Complementary and Alternative Medicine.

[3]  E. Kuffner,et al.  Fatality from diphenhydramine monointoxication: a case report and review of the infant, pediatric, and adult literature. , 2010, The American journal of forensic medicine and pathology.

[4]  A. Sutter,et al.  Antihistamines for the common cold (Withdrawn Paper. 2009, art. no. CD001267) , 2009 .

[5]  R. Hentschel,et al.  Drug dosing error with drops—severe clinical course of codeine intoxication in twins , 2009, European Journal of Pediatrics.

[6]  Z. Vassilev,et al.  Adverse reactions to over‐the‐counter cough and cold products among children: the cases managed out of hospitals , 2009, Journal of clinical pharmacy and therapeutics.

[7]  D. Taverner,et al.  Nasal decongestants for the common cold. , 2009, The Cochrane database of systematic reviews.

[8]  R. Kauffman,et al.  Pediatric fatalities associated with over the counter (nonprescription) cough and cold medications. , 2009, Annals of emergency medicine.

[9]  B. Carleton,et al.  Pharmacogenetics of Neonatal Opioid Toxicity Following Maternal Use of Codeine During Breastfeeding: A Case–Control Study , 2009, Clinical pharmacology and therapeutics.

[10]  F. LoVecchio,et al.  Accidental dextromethorphan ingestions in children less than 5 years old , 2008, Journal of Medical Toxicology.

[11]  R. Eccles,et al.  The Nasal Decongestant Effect of Xylometazoline in the Common Cold , 2008, American journal of rhinology.

[12]  M. Rimsza,et al.  Unexpected Infant Deaths Associated With Use of Cough and Cold Medications , 2008, Pediatrics.

[13]  A. Mitchell,et al.  Cough and Cold Medication Use by US Children, 1999–2006: Results From the Slone Survey , 2008, Pediatrics.

[14]  Ian M Paul,et al.  Effect of honey, dextromethorphan, and no treatment on nocturnal cough and sleep quality for coughing children and their parents. , 2007, Archives of pediatrics & adolescent medicine.

[15]  S. Johansson,et al.  Pholcodine exposure raises serum IgE in patients with previous anaphylaxis to neuromuscular blocking agents , 2007, Allergy.

[16]  S. Badur,et al.  Is acetaminophen as effective as an antihistamine-decongestant-acetaminophen combination in relieving symptoms of acute nasopharyngitis in children? A randomised, controlled trial. , 2007, International journal of pediatric otorhinolaryngology.

[17]  G. L. Collins,et al.  Possible Role of Pseudoephedrine and Other Over‐the‐Counter Cold Medications in the Deaths of Very Young Children , 2007, Journal of forensic sciences.

[18]  J. Meulenbelt,et al.  A case series of xylometazoline overdose in children* , 2007, Clinical toxicology.

[19]  M. Shaffer,et al.  Child Assessment of Dextromethorphan, Diphenhydramine, and Placebo for Nocturnal Cough Due to Upper Respiratory Infection , 2006, Clinical pediatrics.

[20]  A. Halbower,et al.  The trial of infant response to diphenhydramine: the TIRED study--a randomized, controlled, patient-oriented trial. , 2006, Archives of pediatrics & adolescent medicine.

[21]  N. Rashid Medically unexplained myopathy due to ipecac abuse. , 2006, Psychosomatics.

[22]  Alan D. Woolf,et al.  Diphenhydramine and Dimenhydrinate Poisoning: an Evidence-Based Consensus Guideline for Out-of-Hospital Management , 2006, Clinical toxicology.

[23]  S. Johansson,et al.  Pholcodine stimulates a dramatic increase of IgE in IgE‐sensitized individuals. A pilot study , 2006, Allergy.

[24]  L. Lehman,et al.  Over-the-counter cold medications-postmortem findings in infants and the relationship to cause of death. , 2005, Journal of analytical toxicology.

[25]  Y. Daali,et al.  Codeine intoxication associated with ultrarapid CYP2D6 metabolism. , 2004, The New England journal of medicine.

[26]  J. Walburn Effect of Dextromethorphan, Diphenhydramine, and Placebo on Nocturnal Cough and Sleep Quality for Coughing Children and Their Parents , 2004, Pediatrics.

[27]  M. Shaffer,et al.  Dose-response relationship with increasing doses of dextromethorphan for children with cough. , 2004, Clinical therapeutics.

[28]  P. Allotey,et al.  “Social Medication” and the Control of Children: A Qualitative Study of Over-the-Counter Medication Among Australian Children , 2004, Pediatrics.

[29]  K. So,et al.  A case of probable codeine poisoning in a young infant after the use of a proprietary cough and cold medicine. , 2004, Hong Kong medical journal = Xianggang yi xue za zhi.

[30]  F. Bucaretchi,et al.  [Acute exposure to imidazoline derivatives in children]. , 2003, Jornal de pediatria.

[31]  E. Lew,et al.  Fatal cold medication intoxication in an infant. , 2003, Journal of analytical toxicology.

[32]  P. Hartmann,et al.  Pseudoephedrine: effects on milk production in women and estimation of infant exposure via breastmilk. , 2003, British journal of clinical pharmacology.

[33]  Stephen J. Nelson,et al.  Fatal diphenhydramine intoxication in infants. , 2003, Journal of forensic sciences.

[34]  D. Gunnell Paracetamol recall: a natural experiment influencing analgesic poisoning , 2002, The Medical journal of Australia.

[35]  S. Subburaj,et al.  Application and validation of a computerized cough acquisition system for objective monitoring of acute cough: a meta-analysis. , 2001, Chest.

[36]  T. Tong,et al.  Codeine ingestion and apparent life‐threatening event in a neonate , 2001, Pediatrics international : official journal of the Japan Pediatric Society.

[37]  Kim-Ming Wong,et al.  Hypokalemic metabolic acidosis attributed to cough mixture abuse. , 2001, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[38]  R. Howard,et al.  Codeine phosphate in paediatric medicine. , 2001, British journal of anaesthesia.

[39]  R. Roberge,et al.  Dextromethorphan- and pseudoephedrine-induced agitated psychosis and ataxia: case report. , 1999, The Journal of emergency medicine.

[40]  C S Beardsmore,et al.  Nasal flow limitation in children , 1999, Pediatric pulmonology.

[41]  D. Notterman,et al.  Use of codeine- and dextromethorphan-containing cough remedies in children. American Academy of Pediatrics. Committee on Drugs. , 1997, Pediatrics.

[42]  C. Clemens,et al.  Is an antihistamine-decongestant combination effective in temporarily relieving symptoms of the common cold in preschool children? , 1997, The Journal of pediatrics.

[43]  R. Turner,et al.  Effect of topical adrenergic decongestants on middle ear pressure in infants with common colds , 1996 .

[44]  M. Joseph,et al.  Dystonic reaction following recommended use of a cold syrup. , 1995, Annals of emergency medicine.

[45]  P. Cauwenberge,et al.  A Clinical Study to Evaluate the Efficacy of the Antihistamine Doxylamine Succinate in the Relief of Runny Nose and Sneezing Associated with Upper Respiratory Tract Infection , 1995, The Journal of pharmacy and pharmacology.

[46]  G. D. Williams,et al.  Fatal adult respiratory distress syndrome after diphenhydramine toxicity in a child: a case report. , 1995, Critical care medicine.

[47]  W. Feldman,et al.  Over-the-counter cold medications. A critical review of clinical trials between 1950 and 1991. , 1993, JAMA.

[48]  A. Novack,et al.  Efficacy of cough suppressants in children. , 1993, The Journal of pediatrics.

[49]  J. A. Graham,et al.  Diphenhydramine toxicity in a child with varicella. A case report. , 1992, The Journal of family practice.

[50]  M. Korppi,et al.  Antitussives in the Treatment of Acute Transient Cough in Children , 1991, Acta paediatrica Scandinavica.

[51]  E. Pender,et al.  Toxicity with dextromethorphan-containing preparations: a literature review and report of two additional cases. , 1991, Pediatric emergency care.

[52]  S. Ruangkanchanasetr,et al.  Effectiveness of antihistamines in common cold. , 1990, Journal of the Medical Association of Thailand = Chotmaihet thangphaet.

[53]  R. E. Martin du Pan,et al.  [Astemizole in the treatment of acute rhinopharyngitis (common cold). A double-blind study in pediatrics]. , 1988, Revue medicale de la Suisse romande.

[54]  K. Muhlendahl,et al.  CODEINE INTOXICATION IN CHILDHOOD , 1976, The Lancet.

[55]  P. Stolley,et al.  A review of antihistamines and the common cold. , 1975, Pediatrics.

[56]  J. R. Rose Pholcodine plus pseudoephedrine in the treatment of cough. A controlled trial. , 1967, The Practitioner.

[57]  Carter Ch A clinical evaluation of the effectiveness of Novrad and acetylsalicylic acid in children with cough. , 1963 .

[58]  C. H. Carter A CLINICAL EVALUATION OF THE EFFECTIVENESS OF NOVRAD AND ACETYLSALICYLIC ACID IN CHILDREN WITH COUGH , 1963, The American journal of the medical sciences.

[59]  C. H. Carter,et al.  A MEASURE OF THE EFFECTIVENESS OF PROPOXYPHENE ANTITUSSIVES IN CHILDREN , 1961, The American journal of the medical sciences.

[60]  A. Gabrielli,et al.  Codeine, Ultrarapid-Metabolism Genotype, and Postoperative Death , 2009 .

[61]  G. Koren,et al.  Establishing Causality of CNS Depression in Breastfed Infants Following Maternal Codeine Use , 2008, Paediatric drugs.

[62]  T. Sekikawa,et al.  Intoxication with over-the-counter antitussive medication containing dihydrocodeine and chlorpheniramine causes generalized convulsion and mixed acidosis. , 2008, Internal medicine.

[63]  T. Fahey,et al.  Over-the-counter medications for acute cough in children and adults in ambulatory settings. , 2008, The Cochrane database of systematic reviews.

[64]  D. Bolser Cough suppressant and pharmacologic protussive therapy: ACCP evidence-based clinical practice guidelines. , 2006, Chest.

[65]  H. Mackinnon,et al.  Antihistamines for the common cold. , 2003, The Cochrane database of systematic reviews.

[66]  G. Skopp,et al.  The detection of dihydrocodeine and its main metabolites in cases of fatal overdose , 1999, International Journal of Legal Medicine.

[67]  E. Krenzelok,et al.  Position statement: ipecac syrup. American Academy of Clinical Toxicology; European Association of Poisons Centres and Clinical Toxicologists. , 1997, Journal of toxicology. Clinical toxicology.

[68]  M. Anderson,et al.  Antihistamines and the common cold. A review and critique of the literature. , 1996, Journal of general internal medicine.

[69]  N. Holtzman,et al.  Effectiveness of an antihistamine-decongestant combination for young children with the common cold: a randomized, controlled clinical trial. , 1991, The Journal of pediatrics.

[70]  G. Jaffé,et al.  Randomized single-blind trial in general practice comparing the efficacy and palatability of two cough linctus preparations, 'Pholcolix' and 'Actifed' Compound, in children with acute cough. , 1983, Current medical research and opinion.

[71]  H. E. Lewis,et al.  The effect of pholcodine with and without an antihistamine on cough and expectoration. , 1977, British journal of diseases of the chest.

[72]  R. Peck,et al.  An Overview of Safety Issues , 2022 .