Active Electrode IC for EEG and Electrical Impedance Tomography With Continuous Monitoring of Contact Impedance

The IC presented integrates the front-end for EEG and Electrical Impedance Tomography (EIT) acquisition on the electrode, together with electrode-skin contact impedance monitoring and EIT current generation, so as to improve signal quality and integration of the two techniques for brain imaging applications. The electrode size is less than 2 cm2 and only 4 wires connect the electrode to the back-end. The readout circuit is based on a Differential Difference Amplifier and performs single-ended amplification and frequency division multiplexing of the three signals that are sent to the back-end on a single wire which also provides power supply. Since the system's CMRR is a function of each electrode's gain accuracy, an analysis is performed on how this is influenced by mismatches in passive and active components. The circuit is fabricated in 0.35 μm CMOS process and occupies 4 mm2, the readout circuit consumes 360 μW, the input referred noise for bipolar EEG signal acquisition is 0.56 μVRMS between 0.5 and 100 Hz and almost halves if only EEG signal is acquired.

[1]  Lawrence M Knuckey,et al.  EPSM 2005 Workshop - IEC 60601-1: Medical Electrical Equipment - Part 1: General Requirements for Basic Safety and Essential Performance - 3rd Edition 2005 , 2006 .

[2]  Refet Firat Yazicioglu,et al.  A 700µW 8-channel EEG/contact-impedance acquisition system for dry-electrodes , 2012, 2012 Symposium on VLSI Circuits (VLSIC).

[3]  C A Grimbergen,et al.  High-quality recording of bioelectric events , 1990, Medical and Biological Engineering and Computing.

[4]  Refet Firat Yazicioglu,et al.  A 160μW 8-channel active electrode system for EEG monitoring , 2011, 2011 IEEE International Solid-State Circuits Conference.

[5]  Richard H. Bayford,et al.  High-Power CMOS Current Driver With Accurate Transconductance for Electrical Impedance Tomography , 2014, IEEE Transactions on Biomedical Circuits and Systems.

[6]  Fernando Seoane,et al.  AD5933-based electrical bioimpedance spectrometer. Towards textile-enabled applications , 2011, 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[7]  John G. Webster,et al.  Driven-right-leg circuit design , 1983, IEEE Transactions on Biomedical Engineering.

[8]  D. Tucker,et al.  Scalp electrode impedance, infection risk, and EEG data quality , 2001, Clinical Neurophysiology.

[9]  M. Murray,et al.  EEG source imaging , 2004, Clinical Neurophysiology.

[10]  D S Holder,et al.  A review of errors in multi-frequency EIT instrumentation , 2007, Physiological measurement.

[11]  Moritz Dannhauer,et al.  Modeling of the human skull in EEG source analysis , 2011, Human brain mapping.

[12]  W. Eric L. Grimson,et al.  Anatomical atlas-guided diffuse optical tomography of brain activation , 2009, NeuroImage.

[13]  C Gabriel,et al.  The dielectric properties of biological tissues: I. Literature survey. , 1996, Physics in medicine and biology.

[14]  Cathy J. Price,et al.  A review and synthesis of the first 20 years of PET and fMRI studies of heard speech, spoken language and reading , 2012, NeuroImage.

[15]  Roberto Guerrieri,et al.  EIT Forward Problem Parallel Simulation Environment with Anisotropic Tissue and Realistic Electrode Models , 2012, IEEE Transactions on Biomedical Engineering.

[16]  C A Grimbergen,et al.  High-quality recording of bioelectric events , 1991, Medical and Biological Engineering and Computing.

[17]  Roberto Guerrieri,et al.  Active electrode IC combining EEG, electrical impedance tomography, continuous contact impedance measurement and power supply on a single wire , 2011, 2011 Proceedings of the ESSCIRC (ESSCIRC).

[18]  Manuchehr Soleimani,et al.  A DSP Based Multi-Frequency 3D Electrical Impedance Tomography System , 2008, Annals of Biomedical Engineering.

[19]  Christoph M. Michel,et al.  Epileptic source localization with high density EEG: how many electrodes are needed? , 2003, Clinical Neurophysiology.

[20]  André van Schaik,et al.  Code-Division-Multiplexed Electrical Impedance Tomography Spectroscopy , 2009, IEEE Transactions on Biomedical Circuits and Systems.

[21]  Richard H. Bayford,et al.  A multi-frequency bioimpedance measurement ASIC for electrical impedance tomography , 2011, 2011 Proceedings of the ESSCIRC (ESSCIRC).

[22]  R. R. Harrison,et al.  A low-power low-noise CMOS amplifier for neural recording applications , 2003, IEEE J. Solid State Circuits.

[23]  Tzyy-Ping Jung,et al.  Dry-Contact and Noncontact Biopotential Electrodes: Methodological Review , 2010, IEEE Reviews in Biomedical Engineering.

[24]  R H Bayford,et al.  Bioimpedance tomography (electrical impedance tomography). , 2006, Annual review of biomedical engineering.

[25]  Refet Firat Yazicioglu,et al.  A $160~\mu {\rm W}$ 8-Channel Active Electrode System for EEG Monitoring , 2011, IEEE Transactions on Biomedical Circuits and Systems.

[26]  G. Comi,et al.  IFCN standards for digital recording of clinical EEG. International Federation of Clinical Neurophysiology. , 1998, Electroencephalography and clinical neurophysiology.

[27]  W. Guggenbuhl,et al.  A versatile building block: the CMOS differential difference amplifier , 1987 .

[28]  A. C. MettingVanRijn,et al.  Low-cost active electrode improves the resolution in biopotential recordings , 1996, Proceedings of 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[29]  Richard H. Bayford,et al.  Three-Dimensional Electrical Impedance Tomography of Human Brain Activity , 2001, NeuroImage.

[30]  J. Szynowski CMRR analysis of instrumentation amplifiers , 1983 .