Evi1 involved in benzene-induced hematotoxicity via modulation of PI3K/mTOR pathway and negative regulation Serpinb2.

[1]  J. Adame,et al.  Atmospheric benzene measurements in the main metropolitan and industrial areas of Spain from 2014 to 2017 , 2020 .

[2]  Lihua Xie,et al.  Evi-1 Influence on Clinical Progress of Colorectal Cancer Patients. , 2020, Annals of Clinical and Laboratory Science.

[3]  H. Reikvam,et al.  The PI3K-Akt-mTOR Signaling Pathway in Human Acute Myeloid Leukemia (AML) Cells , 2020, International journal of molecular sciences.

[4]  Yuepu Pu,et al.  Benzene exposure induces gut microbiota dysbiosis and metabolic disorder in mice. , 2020, The Science of the total environment.

[5]  A. Basu,et al.  Distinct Roles of mTOR Targets S6K1 and S6K2 in Breast Cancer , 2020, International journal of molecular sciences.

[6]  Zongli Zhang,et al.  Downregulation of EVI1 Expression Inhibits Cell Proliferation and Induces Apoptosis in Hilar Cholangiocarcinoma via the PTEN/AKT Signalling Pathway , 2020, Journal of Cancer.

[7]  Wei Jiang,et al.  Receptor tyrosine kinases in PI3K signaling: The therapeutic targets in cancer. , 2019, Seminars in cancer biology.

[8]  P. Hu,et al.  Retracted: SERPINB2 overexpression inhibited cell proliferation, invasion and migration, led to G2/M arrest, and increased radiosensitivity in nasopharyngeal carcinoma cells , 2019, Journal of radiation research.

[9]  Ji-hua Zhong,et al.  EVI‐1 modulates arsenic trioxide induced apoptosis through JNK signalling pathway in leukemia cells , 2019, Experimental cell research.

[10]  Yuepu Pu,et al.  Plasma metabonomics investigation reveals involvement of fatty acid oxidation in hematotoxicity in Chinese benzene-exposed workers with low white blood cell count , 2018, Environmental Science and Pollution Research.

[11]  J. Lee,et al.  SERPINB2 is a novel indicator of stem cell toxicity , 2018, Cell Death & Disease.

[12]  M. Jiang,et al.  Ecotropic viral integration site 1 regulates the progression of acute myeloid leukemia via MS4A3-mediated TGFβ/EMT signaling pathway. , 2018, Oncology letters.

[13]  J. Yoon,et al.  A brief review of relationship between occupational benzene exposure and hematopoietic cancer , 2018, Annals of Occupational and Environmental Medicine.

[14]  H. Duan,et al.  VNN3, a potential novel biomarker for benzene toxicity, is involved in 1, 4-benzoquinone induced cell proliferation. , 2018, Environmental pollution.

[15]  J. D. Engel,et al.  GATA2 haploinsufficiency accelerates EVI1-driven leukemogenesis. , 2017, Blood.

[16]  M. Odero,et al.  The MDS and EVI1 complex locus (MECOM) isoforms regulate their own transcription and have different roles in the transformation of hematopoietic stem and progenitor cells. , 2017, Biochimica et biophysica acta. Gene regulatory mechanisms.

[17]  M. Konantz,et al.  Evi1 regulates Notch activation to induce zebrafish hematopoietic stem cell emergence , 2016, The EMBO journal.

[18]  P. Valk,et al.  Review: Aberrant EVI1 expression in acute myeloid leukaemia , 2016, British journal of haematology.

[19]  Xidi Wang,et al.  The role of EVI-1 in normal hematopoiesis and myeloid malignancies (Review). , 2015, International journal of oncology.

[20]  M. Kurokawa,et al.  Thrombopoietin/MPL signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 leukemia. , 2014, Blood.

[21]  A. Perkins,et al.  The role of EVI1 in myeloid malignancies. , 2014, Blood cells, molecules & diseases.

[22]  H. Aburatani,et al.  EVI1 oncogene promotes KRAS pathway through suppression of microRNA-96 in pancreatic carcinogenesis , 2014, Oncogene.

[23]  Aditya K Panda,et al.  EVI1 targets ΔNp63 and upregulates the cyclin dependent kinase inhibitor p21 independent of p53 to delay cell cycle progression and cell proliferation in colon cancer cells. , 2013, The international journal of biochemistry & cell biology.

[24]  R. Davuluri,et al.  Global Identification of EVI1 Target Genes in Acute Myeloid Leukemia , 2013, PloS one.

[25]  D. Steinemann,et al.  Activation of Evi1 inhibits cell cycle progression and differentiation of hematopoietic progenitor cells , 2013, Leukemia.

[26]  A. Krämer,et al.  Overexpression of EVI1 interferes with cytokinesis and leads to accumulation of cells with supernumerary centrosomes in G0/1 phase , 2012, Cell cycle.

[27]  M. Kurokawa,et al.  Ecotropic viral integration site 1, stem cell self‐renewal and leukemogenesis , 2012, Cancer science.

[28]  S. Armstrong,et al.  EVI1 is critical for the pathogenesis of a subset of MLL-AF9-rearranged AMLs. , 2012, Blood.

[29]  Luoping Zhang,et al.  Current understanding of the mechanism of benzene-induced leukemia in humans: implications for risk assessment. , 2012, Carcinogenesis.

[30]  T. Kadowaki,et al.  Evi1 is essential for hematopoietic stem cell self-renewal, and its expression marks hematopoietic cells with long-term multilineage repopulating activity , 2011, The Journal of experimental medicine.

[31]  F. Prósper,et al.  Down-regulation of EVI1 is associated with epigenetic alterations and good prognosis in patients with acute myeloid leukemia , 2011, Haematologica.

[32]  Masahiro Nakagawa,et al.  Evi1 represses PTEN expression and activates PI3K/AKT/mTOR via interactions with polycomb proteins. , 2011, Blood.

[33]  M. Butterworth,et al.  The fate of benzene-oxide. , 2010, Chemico-biological interactions.

[34]  Martyn T. Smith,et al.  Advances in understanding benzene health effects and susceptibility. , 2010, Annual review of public health.

[35]  Rusan Chen,et al.  Chronic myelogenous leukemia and benzene exposure: a systematic review and meta-analysis of the case-control literature. , 2009, Chemico-biological interactions.

[36]  B. Löwenberg,et al.  High EVI1 levels predict adverse outcome in acute myeloid leukemia: prevalence of EVI1 overexpression and chromosome 3q26 abnormalities underestimated. , 2008, Blood.

[37]  C. Dunbar,et al.  The MDS1-EVI1 gene complex as a retrovirus integration site: impact on behavior of hematopoietic cells and implications for gene therapy. , 2008, Molecular therapy : the journal of the American Society of Gene Therapy.

[38]  R. Wieser.  The oncogene and developmental regulator EVI1: expression, biochemical properties, and biological functions. , 2007, Gene.

[39]  Gordon B Mills,et al.  mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. , 2006, Cancer research.

[40]  A. Iwama,et al.  Oncogenic transcription factor Evi1 regulates hematopoietic stem cell proliferation through GATA‐2 expression , 2005, The EMBO journal.

[41]  B. Fehse,et al.  Clonal Dominance of Hematopoietic Stem Cells Triggered by Retroviral Gene Marking , 2005, Science.

[42]  G. Nucifora,et al.  EVI1 induces myelodysplastic syndrome in mice. , 2004, The Journal of clinical investigation.

[43]  R. Medcalf,et al.  Plasminogen activator inhibitor type 2: a regulator of monocyte proliferation and differentiation. , 2002, Blood.

[44]  S. Orkin,et al.  Loss of erythropoietin responsiveness in erythroid progenitors due to expression of the Evi-1 myeloid-transforming gene. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[45]  J. Ihle,et al.  Expression of the Evi-1 zinc finger gene in 32Dc13 myeloid cells blocks granulocytic differentiation in response to granulocyte colony-stimulating factor , 1992, Molecular and cellular biology.

[46]  N. Copeland,et al.  Retroviral activation of a novel gene encoding a zinc finger protein in IL-3-dependent myeloid leukemia cell lines , 1988, Cell.

[47]  M. Konantz,et al.  EVI-1 modulates leukemogenic potential and apoptosis sensitivity in human acute lymphoblastic leukemia , 2013, Leukemia.