Fish consumption and risk of major chronic disease in men.

BACKGROUND Although fish consumption may reduce specific disease endpoints, such as sudden cardiac death and prostate cancer, the effects of major chronic disease on total burden, reflecting sums of effects on a variety of endpoints and risk pathways, are not well established. Higher n-6 fatty acid consumption has also been hypothesized to reduce the health benefits of n-3 fatty acids in fish. OBJECTIVE The aim was to study the associations of fish and n-3 fatty acid consumption with risk of total major chronic disease (cardiovascular disease, cancer, and death) and to determine whether a high n-6 intake modifies the associations. DESIGN Lifestyle and other risk factors were assessed every 2 y and diet every 4 y in 40,230 US male health professionals aged 40-75 y and free of major chronic disease at baseline in 1986. During 18 y of follow-up, 9715 major chronic disease events occurred, including 3639 cardiovascular disease events, 4690 cancers, and 1386 deaths from other causes. RESULTS After multivariable adjustment, neither fish nor dietary n-3 fatty acid consumption was significantly associated with risk of total major chronic disease. Compared with fish consumption of <1 serving/mo, consumption of 1 serving/wk and of 2-4 servings/wk was associated with a lower risk of total cardiovascular disease of approximately 15%. No significant associations were seen with cancer risk. Higher or lower n-6 fatty acid intake did not significantly modify the results (P for interaction > 0.10). CONCLUSIONS Modest fish consumption was associated with a lower risk of total cardiovascular disease, consistent with cardiac mortality benefits but not with total cancer or overall major chronic disease; n-6 fatty acid consumption did not influence these relations.

[1]  M. Stampfer,et al.  A prospective study of fish, marine fatty acids, and bladder cancer risk among men and women (United States) , 2006, Cancer Causes & Control.

[2]  T. Raghunathan,et al.  Dietary intake and cell membrane levels of long-chain n-3 polyunsaturated fatty acids and the risk of primary cardiac arrest. , 1995, JAMA.

[3]  R. Burger,et al.  Use of a dummy (pacifier) during sleep and risk of sudden infant death syndrome (SIDS): population based case-control study , 2005, BMJ : British Medical Journal.

[4]  M. Stampfer,et al.  A Prospective Study of Polyunsaturated Fatty Acid Levels in Blood and Prostate Cancer Risk , 2007, Cancer Epidemiology Biomarkers & Prevention.

[5]  D. Mozaffarian,et al.  n-3 Polyunsaturated fatty acids, fatal ischemic heart disease, and nonfatal myocardial infarction in older adults: the Cardiovascular Health Study. , 2003, The American journal of clinical nutrition.

[6]  Dariush Mozaffarian,et al.  Fish intake, contaminants, and human health: evaluating the risks and the benefits. , 2006, JAMA.

[7]  A. Simopoulos,et al.  Essential fatty acids in health and chronic disease. , 1999, The American journal of clinical nutrition.

[8]  D. Mozaffarian,et al.  Fish consumption and stroke risk in elderly individuals: the cardiovascular health study. , 2005, Archives of internal medicine.

[9]  J. Manson,et al.  Types of Dietary Fat and Risk of Coronary Heart Disease: A Critical Review , 2001, Journal of the American College of Nutrition.

[10]  W. Willett,et al.  Dietary intake of n-3 and n-6 fatty acids and the risk of prostate cancer. , 2004, The American journal of clinical nutrition.

[11]  G A Colditz,et al.  Reproducibility and validity of an expanded self-administered semiquantitative food frequency questionnaire among male health professionals. , 1992, American journal of epidemiology.

[12]  H. Blackburn,et al.  Cardiovascular survey methods. , 1969, Monograph series. World Health Organization.

[13]  P. Hubert,et al.  Dietary (n-3) and (n-6) polyunsaturated fatty acids rapidly modify fatty acid composition and insulin effects in rat adipocytes. , 1998, The Journal of nutrition.

[14]  P. Kris-Etherton,et al.  Polyunsaturated fatty acids in the food chain in the United States. , 2000, The American journal of clinical nutrition.

[15]  E. Rimm,et al.  Habitual Dietary Intake of n-3 and n-6 Fatty Acids in Relation to Inflammatory Markers Among US Men and Women , 2003, Circulation.

[16]  E. Rimm,et al.  The assessment of alcohol consumption by a simple self-administered questionnaire. , 1991, American journal of epidemiology.

[17]  D. Mozaffarian,et al.  Interplay Between Different Polyunsaturated Fatty Acids and Risk of Coronary Heart Disease in Men , 2005, Circulation.

[18]  W. Willett,et al.  Adherence to the Dietary Guidelines for Americans and risk of major chronic disease in women. , 2000, The American journal of clinical nutrition.

[19]  M. Fay,et al.  Effect of different types and amounts of fat on the development of mammary tumors in rodents: a review. , 1997, Cancer research.

[20]  E. Rimm,et al.  Intake of fat, meat, and fiber in relation to risk of colon cancer in men. , 1994, Cancer research.

[21]  Meir J. Stampfer,et al.  Total energy intake: implications for epidemiologic analyses. , 1986, American journal of epidemiology.

[22]  E. Rimm,et al.  Vitamin E consumption and the risk of coronary heart disease in men. , 1993, The New England journal of medicine.

[23]  E. Rimm,et al.  Validity of Self‐Reported Waist and Hip Circumferences in Men and Women , 1990, Epidemiology.

[24]  A. Dyer,et al.  Fish Consumption and Incidence of Stroke: A Meta-Analysis of Cohort Studies , 2004, Stroke.

[25]  J. Mason,et al.  Nutrition chemoprevention of gastrointestinal cancers: a critical review. , 2009, Nutrition reviews.

[26]  J. Manson,et al.  Fish consumption and risk of sudden cardiac death. , 1998, JAMA.

[27]  A. Dyer,et al.  Accumulated Evidence on Fish Consumption and Coronary Heart Disease Mortality: A Meta-Analysis of Cohort Studies , 2004, Circulation.

[28]  D Spiegelman,et al.  Dietary fat and coronary heart disease: a comparison of approaches for adjusting for total energy intake and modeling repeated dietary measurements. , 1999, American journal of epidemiology.

[29]  J. Manson,et al.  Dietary intake of α-linolenic acid and risk of fatal ischemic heart disease among women , 1999 .

[30]  Kari Seppänen,et al.  Mercury, Fish Oils, and Risk of Acute Coronary Events and Cardiovascular Disease, Coronary Heart Disease, and All-Cause Mortality in Men in Eastern Finland , 2004, Arteriosclerosis, thrombosis, and vascular biology.

[31]  Frans J Kok,et al.  Mercury, fish oils, and the risk of myocardial infarction. , 2002, The New England journal of medicine.

[32]  E. Rimm,et al.  Fish consumption and risk of stroke in men. , 2002, JAMA.

[33]  P. Calder,et al.  Polyunsaturated fatty acids, inflammation, and immunity , 2001, Lipids.

[34]  F. D. Weinfeld,et al.  The National Survey of Stroke. Clinical findings. , 1981, Stroke.

[35]  E. Rimm,et al.  Comparison of measures of fatty acid intake by subcutaneous fat aspirate, food frequency questionnaire, and diet records in a free-living population of US men. , 1992, American journal of epidemiology.

[36]  E. Rimm,et al.  Reproducibility and Validity of a Self‐Administered Physical Activity Questionnaire for Male Health Professionals , 1996, Epidemiology.

[37]  D. Carpenter,et al.  Consumption advisories for salmon based on risk of cancer and noncancer health effects. , 2006, Environmental research.