Progress in multidisciplinary treatment of hemorrhagic radiation proctitis

With the development and wide application of radiotherapy technology, the incidence of radiation proctitis (RP) caused by radiotherapy for pelvic malignant tumors tends to increase, especially the treatment of hemorrhagic RP (HRP) is very difficult. Complications such as intestinal necrosis and perforation cause great pain and inconvenience to patients. How to effectively and safely treat HRP is an urgent clinical problem to be solved. This article reviews the progress of multidisciplinary treatment of RP, especially HRP, in recent years, and focuses on the progress of formalin in the treatment of hemorrhagic radiation proctitis.

[1]  [Chinese expert consensus on multidisciplinary diagnosis and treatment of radiation rectal injury (2021 edition)]. , 2021, Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery.

[2]  F. Tuma,et al.  Radiation Proctitis and Management Strategies , 2021, Clinical endoscopy.

[3]  Derick R. Peterson,et al.  Radiogenomics Consortium Genome-Wide Association Study Meta-Analysis of Late Toxicity After Prostate Cancer Radiotherapy , 2019, Journal of the National Cancer Institute.

[4]  S. Vats,et al.  Four percent formalin application for the management of radiation proctitis in carcinoma cervix patients: An effective, safe, and economical practice , 2019, Journal of cancer research and therapeutics.

[5]  Mengyuan Yang,et al.  Clinical analysis of formalin therapy for hemorrhagic radiation proctitis , 2018 .

[6]  Lei Wang,et al.  [Chinese consensus on diagnosis and treatment of radiation proctitis (2018)]. , 2018, Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery.

[7]  Sophia Kwon,et al.  Non-Cardiac Chest Pain: A Review of Environmental Exposure-Associated Comorbidities and Biomarkers. , 2018, EMJ. Gastroenterology.

[8]  J. Gururajachar,et al.  Compliance with bladder protocol during concurrent chemoradiation for cancer of the cervix and its impact on enteritis: A prospective observational study. , 2018, Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology.

[9]  F. James,et al.  The impact of patient positioning and use of belly board on small bowel toxicity in patients receiving pelvic radiotherapy for gynecological malignancies , 2017, Journal of cancer research and therapeutics.

[10]  N. Haboubi,et al.  Pelvic radiation therapy: Between delight and disaster. , 2015, World journal of gastrointestinal surgery.

[11]  Qiu Xiao-che.  Research progress in chronic radiation enteritis , 2015 .

[12]  A. Wilson,et al.  Sucralfate paste enema: a new method of topical treatment for haemorrhagic radiation proctitis , 2014, Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland.

[13]  J. Horwhat,et al.  Cryotherapy for treatment of radiation proctitis. , 2014, Gastrointestinal endoscopy.

[14]  M. Schoeman,et al.  Argon plasma coagulation therapy versus topical formalin for intractable rectal bleeding and anorectal dysfunction after radiation therapy for prostate carcinoma. , 2013, International journal of radiation oncology, biology, physics.

[15]  S. Ricksten,et al.  Hyperbaric oxygen treatment in radiation-induced cystitis and proctitis: a prospective cohort study on patient-perceived quality of recovery. , 2013, International journal of radiation oncology, biology, physics.

[16]  C. Sahakitrungruang,et al.  A Randomized Controlled Trial Comparing Colonic Irrigation and Oral Antibiotics Administration Versus 4% Formalin Application for Treatment of Hemorrhagic Radiation Proctitis , 2012, Diseases of the colon and rectum.

[17]  N. Sijtsema,et al.  Systematic review of the role of a belly board device in radiotherapy delivery in patients with pelvic malignancies. , 2012, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[18]  S. Elad,et al.  Systematic review of agents for the management of gastrointestinal mucositis in cancer patients , 2012, Supportive Care in Cancer.

[19]  Y. Shaib,et al.  Treatment of chronic radiation proctitis with cryoablation. , 2011, Gastrointestinal Endoscopy.

[20]  Rajeev Gupta,et al.  Circadian variation in radiation‐induced intestinal mucositis in patients with cervical carcinoma , 2010, Cancer.

[21]  V. Chauhan,et al.  Intrarectal application of formalin for chronic radiation proctitis: a simple, cheap and effective treatment. , 2010, Tropical gastroenterology : official journal of the Digestive Diseases Foundation.

[22]  R. R. Raman.  Two Percent Formalin Retention Enemas for Hemorrhagic Radiation Proctitis: A Preliminary Report , 2007, Diseases of the colon and rectum.

[23]  Y. Park,et al.  Formalin Application for the Treatment of Radiation-Induced Hemorrhagic Proctitis , 2007, Yonsei medical journal.

[24]  H. Sorbye,et al.  Sucralfate does not ameliorate acute radiation proctitis: randomised study and meta-analysis. , 2005, Clinical oncology (Royal College of Radiologists (Great Britain)).

[25]  F. Patel,et al.  Radiation-induced proctosigmoiditis , 2005, Digestive Diseases and Sciences.

[26]  D. Dearnaley,et al.  How patients manage gastrointestinal symptoms after pelvic radiotherapy , 2003, Alimentary pharmacology & therapeutics.

[27]  B. Župančić,et al.  Metronidazole in the treatment of chronic radiation proctitis: clinical trial. , 2000, Croatian medical journal.

[28]  N. Talley,et al.  Short-chain fatty acids in the treatment of radiation proctitis , 1997, Diseases of the colon and rectum.

[29]  J. Spencer,et al.  Natural history and surgical management of radiation enteritis , 1987, The British journal of surgery.

[30]  W. Duncan,et al.  Late results of mucosal proctectomy and colo‐anal sleeve anastomosis for chronic irradiation rectal injury , 1987, The British journal of surgery.

[31]  J. Spencer,et al.  Surgical aspects of radiation injury to the intestine , 1979, The British journal of surgery.