论文信息 - Drug delivery: One nanoparticle, one kill. - 字舞流文

Drug delivery: One nanoparticle, one kill.

By wrapping a ligand-functionalized lipid membrane around a silica core, nanoparticles with a fluid surface are created. These combine unprecedented specificity in binding to cancer cells with the combinatorial delivery of drug cocktails.

Darrell J Irvine | D. Irvine

[1] Molly S. Shoichet,et al. Tunable immunonanoparticle binding to cancer cells: thermodynamic analysis of targeted drug delivery vehicles , 2009 .

[2] Sangeeta N Bhatia,et al. Ligand-clustered "patchy" nanoparticles for modulated cellular uptake and in vivo tumor targeting. , 2010, Angewandte Chemie.

[3] Robert Langer,et al. Impact of nanotechnology on drug delivery. , 2009, ACS nano.

[4] R. Kane,et al. Polyvalent inhibitors of anthrax toxin that target host receptors , 2006, Proceedings of the National Academy of Sciences.

[5] V. Torchilin. Recent advances with liposomes as pharmaceutical carriers , 2005, Nature Reviews Drug Discovery.

[6] Mark E. Davis,et al. Nanoparticle therapeutics: an emerging treatment modality for cancer , 2008, Nature Reviews Drug Discovery.

[7] Mitsuhiro Nishida,et al. Antigen Chemically Coupled to the Surface of Liposomes Are Cross-Presented to CD8+ T Cells and Induce Potent Antitumor Immunity1 , 2006, The Journal of Immunology.