LKB1 inhibits the proliferation of gastric cancer cells by suppressing the nuclear translocation of Yap and β-catenin.
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H. Xi | Lin Chen | J. Cui | S. Bian | Xiaoming Zhu | Ke-cheng Zhang | Liangang Ma | H. Qin
[1] J. Hung,et al. Angiomotin decreases lung cancer progression by sequestering oncogenic YAP/TAZ and decreasing Cyr61 expression , 2014, Oncogene.
[2] S. Park,et al. High-Throughput Sequencing and Copy Number Variation Detection Using Formalin Fixed Embedded Tissue in Metastatic Gastric Cancer , 2014, PloS one.
[3] S. Mader,et al. LKB1 when associated with methylatedERα is a marker of bad prognosis in breast cancer , 2014, International journal of cancer.
[4] Yingyong Hou,et al. YAP inhibits squamous transdifferentiation of Lkb1-deficient lung adenocarcinoma through ZEB2-dependent DNp63 repression , 2014, Nature Communications.
[5] K. Kaestner,et al. The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver , 2014, Nature Communications.
[6] L. Tsai,et al. LKB1 loss by alteration of the NKX2-1/p53 pathway promotes tumor malignancy and predicts poor survival and relapse in lung adenocarcinomas , 2014, Oncogene.
[7] Giuseppe Basso,et al. YAP/TAZ Incorporation in the β-Catenin Destruction Complex Orchestrates the Wnt Response , 2014, Cell.
[8] H. Jeon,et al. Genetic Variations in STK11,PRKAA1, and TSC1 Associated with Prognosis for Patients with Colorectal Cancer , 2014, Annals of Surgical Oncology.
[9] H. Ji,et al. A peptide mimicking VGLL4 function acts as a YAP antagonist therapy against gastric cancer. , 2014, Cancer cell.
[10] W. Hung,et al. Utilization of Liquid Chromatography Mass Spectrometry Analyses to Identify LKB1–APC Interaction in Modulating Wnt/β-Catenin Pathway of Lung Cancer Cells , 2014, Molecular Cancer Research.
[11] Kwok-Kin Wong,et al. A genetic screen identifies an LKB1–MARK signalling axis controlling the Hippo–YAP pathway , 2013, Nature Cell Biology.
[12] F. Feo,et al. Pleiotropic effects of methionine adenosyltransferases deregulation as determinants of liver cancer progression and prognosis. , 2013, Journal of hepatology.
[13] C. Wells,et al. LKB1 tumor suppressor regulates AMP kinase/mTOR-independent cell growth and proliferation via the phosphorylation of Yap , 2013, Oncogene.
[14] Cristian Coarfa,et al. SOX2 regulates YAP1 to maintain stemness and determine cell fate in the osteo-adipo lineage. , 2013, Cell reports.
[15] Jill P. Mesirov,et al. β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis , 2012, Cell.
[16] Joon-Oh Park,et al. High-Throughput Mutation Profiling Identifies Frequent Somatic Mutations in Advanced Gastric Adenocarcinoma , 2012, PloS one.
[17] Julia B. Cordero,et al. Acute WNT signalling activation perturbs differentiation within the adult stomach and rapidly leads to tumour formation , 2012, Oncogene.
[18] E. Nishida,et al. A molecular mechanism that links Hippo signalling to the inhibition of Wnt/β‐catenin signalling , 2012, The EMBO journal.
[19] H. Xi,et al. Aberrant expression of EphA3 in gastric carcinoma: correlation with tumor angiogenesis and survival , 2012, Journal of Gastroenterology.
[20] G. Yochum,et al. Wnt/β-Catenin Signaling Regulates Yes-associated Protein (YAP) Gene Expression in Colorectal Carcinoma Cells* , 2012, The Journal of Biological Chemistry.
[21] D. Sharma,et al. Leptin-induced Epithelial-Mesenchymal Transition in Breast Cancer Cells Requires β-Catenin Activation via Akt/GSK3- and MTA1/Wnt1 Protein-dependent Pathways* , 2012, The Journal of Biological Chemistry.
[22] J. Bader,et al. Functional dissection of lysine deacetylases reveals that HDAC1 and p300 regulate AMPK , 2011, Nature.
[23] M. Perez-Moreno,et al. Epithelial cell polarity, stem cells and cancer , 2011, Nature Reviews Cancer.
[24] W. Yung,et al. FoxM1 promotes β-catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesis. , 2011, Cancer cell.
[25] Leah E. Mechanic,et al. Frequent homozygous deletion of the LKB1/STK11 gene in non-small cell lung cancer , 2011, Oncogene.
[26] D. Birnbaum,et al. Genome profiling of pancreatic adenocarcinoma , 2011, Genes, chromosomes & cancer.
[27] James F Amatruda,et al. Genome-Wide RNAi Screen Reveals Disease-Associated Genes That Are Common to Hedgehog and Wnt Signaling , 2011, Science Signaling.
[28] A. Ashworth,et al. LKB1 Haploinsufficiency Cooperates With Kras to Promote Pancreatic Cancer Through Suppression of p21-Dependent Growth Arrest , 2010, Gastroenterology.
[29] M. Brown,et al. YAP Dysregulation by Phosphorylation or ΔNp63-mediated Gene Repression Promotes Proliferation, Survival and Migration in Head and Neck Cancer Subsets , 2010, Oncogene.
[30] Kwok-Kin Wong,et al. Somatic LKB1 Mutations Promote Cervical Cancer Progression , 2009, PloS one.
[31] J. Ptak,et al. Somatic mutations of GUCY2F, EPHA3, and NTRK3 in human cancers , 2006, Human mutation.
[32] H. Kuwano,et al. Clinical significance of mucin phenotype, β‐catenin and matrix metalloproteinase 7 in early undifferentiated gastric carcinoma , 2005, The British journal of surgery.
[33] R. DePinho,et al. LKB1 (XEEK1) regulates Wnt signalling in vertebrate development , 2003, Nature Cell Biology.
[34] M. Stratton,et al. A serine/threonine kinase gene defective in Peutz–Jeghers syndrome , 1998, Nature.
[35] M. Fassan,et al. High-throughput mutation profiling identifies novel molecular dysregulation in high-grade intraepithelial neoplasia and early gastric cancers , 2013, Gastric Cancer.
[36] H. S. Kim,et al. Genetic analysis of the LKB1/STK11 gene in hepatocellular carcinomas. , 2004, European journal of cancer.