Properties of developmental gene regulatory networks

The modular components, or subcircuits, of developmental gene regulatory networks (GRNs) execute specific developmental functions, such as the specification of cell identity. We survey examples of such subcircuits and relate their structures to corresponding developmental functions. These relations transcend organisms and genes, as illustrated by the similar structures of the subcircuits controlling the specification of the mesectoderm in the Drosophila embryo and the endomesoderm in the sea urchin, even though the respective subcircuits are composed of nonorthologous regulatory genes.

[1]  E. Davidson,et al.  A missing link in the sea urchin embryo gene regulatory network: hesC and the double-negative specification of micromeres , 2007, Proceedings of the National Academy of Sciences.

[2]  Manu,et al.  Characterization of the Drosophila segment determination morphome. , 2008, Developmental biology.

[3]  A. Tsirigos,et al.  Anterior-posterior positional information in the absence of a strong Bicoid gradient , 2009, Proceedings of the National Academy of Sciences.

[4]  Stephen T. Crews,et al.  The Drosophila single-minded gene encodes a helix-loop-helix protein that acts as a master regulator of CNS midline development , 1991, Cell.

[5]  R. Krumlauf,et al.  A regulatory module embedded in the coding region of Hoxa2 controls expression in rhombomere 2 , 2008, Proceedings of the National Academy of Sciences.

[6]  D. McClay,et al.  LvNumb works synergistically with Notch signaling to specify non-skeletal mesoderm cells in the sea urchin embryo , 2008, Development.

[7]  T. Sauka-Spengler,et al.  Dissecting early regulatory relationships in the lamprey neural crest gene network , 2008, Proceedings of the National Academy of Sciences.

[8]  O. Hobert.  From the Cover: Gene Networks in Development and Evolution Special Feature Sackler Colloquium: Regulatory logic of neuronal diversity: Terminal selector genes and selector motifs , 2008 .

[9]  Eric Wieschaus,et al.  Dorsal-ventral pattern of Delta trafficking is established by a Snail-Tom-Neuralized pathway. , 2006, Developmental cell.

[10]  E. Davidson.  The Regulatory Genome: Gene Regulatory Networks In Development And Evolution , 2006 .

[11]  Eric H Davidson,et al.  Cis‐regulatory control of the nodal gene, initiator of the sea urchin oral ectoderm gene network , 2007, Developmental biology.

[12]  E. Davidson,et al.  Gene regulatory networks for development. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[13]  Eric H. Davidson,et al.  Built to Run, Not Fail , 2007, Science.

[14]  E. Davidson,et al.  Developmental gene regulatory network architecture across 500 million years of echinoderm evolution , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[15]  D. Papatsenko,et al.  How the Dorsal gradient works: Insights from postgenome technologies , 2008, Proceedings of the National Academy of Sciences.

[16]  E. Davidson,et al.  A new method, using cis-regulatory control, for blocking embryonic gene expression. , 2008, Developmental biology.

[17]  Eric H Davidson,et al.  Development. Built to run, not fail. , 2007, Science.

[18]  Joshua B. Gross,et al.  Synteny and candidate gene prediction using an anchored linkage map of Astyanax mexicanus , 2008, Proceedings of the National Academy of Sciences.

[19]  Paul W Sternberg,et al.  The Caenorhabditis elegans vulva: A post-embryonic gene regulatory network controlling organogenesis , 2008, Proceedings of the National Academy of Sciences.

[20]  Hamid Bolouri,et al.  A gene regulatory network armature for T lymphocyte specification , 2008, Proceedings of the National Academy of Sciences.

[21]  E. Davidson,et al.  cis-regulatory processing of Notch signaling input to the sea urchin glial cells missing gene during mesoderm specification. , 2006, Developmental biology.

[22]  J C Smith,et al.  The T-box transcription factor Brachyury regulates expression of eFGF through binding to a non-palindromic response element. , 1998, Development.

[23]  Eric H Davidson,et al.  Gene regulatory network subcircuit controlling a dynamic spatial pattern of signaling in the sea urchin embryo , 2008, Proceedings of the National Academy of Sciences.

[24]  J. Gibert,et al.  Redundant mechanisms mediate bristle patterning on the Drosophila thorax , 2008, Proceedings of the National Academy of Sciences.

[25]  E. Davidson,et al.  cis-Regulatory inputs of the wnt8 gene in the sea urchin endomesoderm network. , 2005, Developmental biology.

[26]  Eric H Davidson,et al.  A Gene Regulatory Network Subcircuit Drives a Dynamic Pattern of Gene Expression , 2007, Science.

[27]  J. Smith,et al.  The Xenopus Brachyury promoter is activated by FGF and low concentrations of activin and suppressed by high concentrations of activin and by paired-type homeodomain proteins. , 1997, Genes & development.

[28]  E. Davidson,et al.  Global regulatory logic for specification of an embryonic cell lineage , 2008, Proceedings of the National Academy of Sciences.