Space cell physiology and space biotechnology in Russia.

Publisher Summary Space biotechnology is a complex of novel technologies aimed at the production in microgravity of bio-objects and unique biological materials, among them diagnostic, therapeutic and preventive preparations. This is one of the major areas of research aboard piloted orbital stations that will allow the use in microgravity of new methods for producing useful biosamples. Experimental research in the fields of cell physiology and biotechnology carried out by Russian scientists on the board the orbital station Mir has shown that the effects of space flight factors on cells and biotechnology processes are multicomponent and significant. They could increase the possibility of developing new strains and substances for medical, pharmaceutical, and industrial applications. It could be said that the positive and negative experiences arising from space investigations in this field have brought about not only a new knowledge about the role of gravitational factors in cell processes, but also the creation of a new, young biological discipline—space biotechnology, which will expand on the International Space Station.

[1]  E L Kordyum,et al.  Effects of altered gravity on plant cell processes: results of recent space and clinostatic experiments. , 1994, Advances in space research : the official journal of the Committee on Space Research.

[2]  D L Bubenheim,et al.  Analysis of the spaceflight effects on growth and development of Super Dwarf wheat grown on the Space Station Mir. , 2000, Journal of plant physiology.

[3]  A Cogoli,et al.  Gravitational physiology of human immune cells: a review of in vivo, ex vivo and in vitro studies. , 1996, Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology.

[4]  M. Tairbekov,et al.  Experimental and theoretical analysis of the influence of gravity at the cellular level: a review. , 1983, Advances in space research : the official journal of the Committee on Space Research.

[5]  K. S. Narayan,et al.  Three-dimensional growth patterns of various human tumor cell lines in simulated microgravity of a NASA bioreactor , 1997, In Vitro Cellular & Developmental Biology - Animal.

[6]  Gordana Vunjak-Novakovic,et al.  Microgravity tissue engineering , 1997, In Vitro Cellular & Developmental Biology - Animal.

[7]  I. V. Konstantinova,et al.  The immune system in space and other extreme conditions , 1991 .

[8]  D Meshkov,et al.  The natural cytotoxicity in cosmonauts on board space stations. , 1995, Acta astronautica.

[9]  G. Vunjak‐Novakovic,et al.  Tissue engineering of cartilage in space. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[10]  P. Albersheim,et al.  Host-Pathogen Interactions: II. Parameters Affecting Polysaccharide-degrading Enzyme Secretion by Colletotrichum lindemuthianum Grown in Culture. , 1971, Plant Physiology.

[11]  Y. Y. Shepelev,et al.  Biological life-support systems , 1975 .