Interaction of ionizing radiation, genetically active chemicals, and radiofrequency radiation in human and rodent cells. Final report 1 Oct 87-30 Sep 89

The purpose of this project was to investigate the possible interaction between radiofrequency radiation (RFR) and agents which are known to damage DNA. Experiments were performed using exposures of CHO cells to 350, 850, 1200, and 2450 MHz RFR at up to 40 W/kg and temperatures ranging from 37 to 40 C. No genotoxic effect was observed by sister chromotid exchange induction, chromosome aberration induction, or gene mutation (at the thymidine kinase locus). At levels at or below 10 mW/cm2 and specific absorption rates (SARs) at or below 4 W/kg, there was no evidence that DNA repair was induced or repair of preexisting DNA damage was inhibited. Adriamycin but not mitomycin c caused a statistically significant increase in the frequency of aberrant cells at 40 C with or without RFR. These observations support thermal mechanisms of RFR interaction.

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