Cellular Transformation by the HTLV-I Tax Protein, a Jack-of-All-Trades

[1]  K. Jeang,et al.  Human T-cell Lymphotropic Virus Type 1 Tax Inhibits Transforming Growth Factor-β Signaling by Blocking the Association of Smad Proteins with Smad-binding Element* , 2002, The Journal of Biological Chemistry.

[2]  M. Lairmore,et al.  Critical Role of Human T-Lymphotropic Virus Type 1 Accessory Proteins in Viral Replication and Pathogenesis , 2002, Microbiology and Molecular Biology Reviews.

[3]  H. Koeffler,et al.  Role of tumor suppressor genes in the development of adult T cell leukemia/lymphoma (ATLL) , 2002, Leukemia.

[4]  S. Hinrichs,et al.  Human T-Lymphotropic Virus Type 1 Oncoprotein Tax Promotes S-Phase Entry but Blocks Mitosis , 2002, Journal of Virology.

[5]  K. Jeang,et al.  Prevalent Loss of Mitotic Spindle Checkpoint in Adult T-cell Leukemia Confers Resistance to Microtubule Inhibitors* , 2002, The Journal of Biological Chemistry.

[6]  J. Bartek,et al.  Mammalian G1- and S-phase checkpoints in response to DNA damage. , 2001, Current opinion in cell biology.

[7]  S. J. Marriott,et al.  Accelerated G1 Phase Progression Induced by the Human T Cell Leukemia Virus Type I (HTLV-I) Tax Oncoprotein* , 2001, The Journal of Biological Chemistry.

[8]  J. Labbé,et al.  Mps1 Is a Kinetochore-Associated Kinase Essential for the Vertebrate Mitotic Checkpoint , 2001, Cell.

[9]  H. Nilsen,et al.  Base excision repair in a network of defence and tolerance. , 2001, Carcinogenesis.

[10]  G. Franchini,et al.  Molecular biology and pathogenesis of the human T‐cell leukaemia/lymphotropic virus Type‐1 (HTLV‐1) , 2001, International journal of experimental pathology.

[11]  K. Ohtani,et al.  Molecular mechanism of cell cycle progression induced by the oncogene product Tax of human T-cell leukemia virus type I , 2001, Oncogene.

[12]  Yuetsu Tanaka,et al.  Human T-cell leukemia virus type I oncoprotein Tax represses Smad-dependent transforming growth factor beta signaling through interaction with CREB-binding protein/p300. , 2001, Blood.

[13]  K. Ohtani,et al.  Direct trans-activation of the human cyclin D2 gene by the oncogene product Tax of human T-cell leukemia virus type I , 2001, Oncogene.

[14]  J. Bartek,et al.  Pathways governing G1/S transition and their response to DNA damage , 2001, FEBS letters.

[15]  K. Jeang,et al.  Genetic Evidence of a Role for ATM in Functional Interaction between Human T-Cell Leukemia Virus Type 1 Tax and p53 , 2001, Journal of Virology.

[16]  S. J. Marriott,et al.  Suppression of DNA repair by HTLV type 1 Tax correlates with Tax trans-activation of proliferating cell nuclear antigen gene expression. , 2000, AIDS research and human retroviruses.

[17]  D. Saul,et al.  Tax-dependent stimulation of G1 phase-specific cyclin-dependent kinases and increased expression of signal transduction genes characterize HTLV type 1-transformed T cells. , 2000, AIDS research and human retroviruses.

[18]  K. Jeang,et al.  Clastogenic Effect of the Human T-cell Leukemia Virus Type I Tax Oncoprotein Correlates with Unstabilized DNA Breaks* , 2000, The Journal of Biological Chemistry.

[19]  K. Ohtani,et al.  Cell Type-specific E2F Activation and Cell Cycle Progression Induced by the Oncogene Product Tax of Human T-cell Leukemia Virus Type I* , 2000, The Journal of Biological Chemistry.

[20]  Yoichi Taya,et al.  HTLV-1 Tax oncoprotein represses the p53-mediated trans-activation function through coactivator CBP sequestration , 2000, Oncogene.

[21]  K. Jeang,et al.  HTLV-I Tax and cell cycle progression. , 2000, Progress in cell cycle research.

[22]  D. Meek,et al.  Mechanisms of switching on p53: a role for covalent modification? , 1999, Oncogene.

[23]  F. Kashanchi,et al.  Transcriptional Up-Regulation of the Cyclin D2 Gene and Acquisition of New Cyclin-Dependent Kinase Partners in Human T-Cell Leukemia Virus Type 1-Infected Cells , 1999, Journal of Virology.

[24]  H. Giebler,et al.  Binding of p53 to the KIX Domain of CREB Binding Protein , 1999, The Journal of Biological Chemistry.

[25]  Takeshi Suzuki,et al.  Tax protein of HTLV-1 inhibits CBP/p300-mediated transcription by interfering with recruitment of CBP/p300 onto DNA element of E-box or p53 binding site , 1999, Oncogene.

[26]  M. Yoshida,et al.  Down-regulation of the INK4 family of cyclin-dependent kinase inhibitors by tax protein of HTLV-1 through two distinct mechanisms. , 1999, Virology.

[27]  J. Nyborg,et al.  Binding of the human T-cell leukemia virus Tax protein to the coactivator CBP interferes with CBP-mediated transcriptional control , 1999, Oncogene.

[28]  S. Philpott,et al.  Defective DNA repair in cells with human T-cell leukemia/bovine leukemia viruses: role of tax gene. , 1999, Journal of the National Cancer Institute.

[29]  C. Devaux,et al.  Multiple control levels of cell proliferation by human T-cell leukemia virus type 1 Tax protein. , 1999, Virology.

[30]  A. Cereseto,et al.  Limiting amounts of p27Kip1 correlates with constitutive activation of cyclin E-CDK2 complex in HTLV-I-transformed T-cells , 1999, Oncogene.

[31]  M. Tomonaga,et al.  High rate of chromosomal abnormalities in HTLV-I-infected T-cell colonies derived from prodromal phase of adult T-cell leukemia: a study of IL-2-stimulated colony formation in methylcellulose. , 1999, Cancer genetics and cytogenetics.

[32]  M. Yoshida,et al.  Trans-activator Tax of human T-cell leukemia virus type 1 enhances mutation frequency of the cellular genome. , 1999, Virology.

[33]  T. Herdegen,et al.  Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins , 1998, Brain Research Reviews.

[34]  A. Cereseto,et al.  Human T-Cell Lymphotropic/Leukemia Virus Type 1 Tax Abrogates p53-Induced Cell Cycle Arrest and Apoptosis through Its CREB/ATF Functional Domain , 1998, Journal of Virology.

[35]  Andrew W. Murray,et al.  Spindle Checkpoint Protein Xmad1 Recruits Xmad2 to Unattached Kinetochores , 1998, The Journal of cell biology.

[36]  C. Sardet,et al.  Activation of E2F-mediated Transcription by Human T-cell Leukemia Virus Type I Tax Protein in a p16 INK4A -negative T-cell Line* , 1998, The Journal of Biological Chemistry.

[37]  Kuan-Teh Jeang,et al.  Human T Cell Leukemia Virus Type 1 Oncoprotein Tax Targets the Human Mitotic Checkpoint Protein MAD1 , 1998, Cell.

[38]  Bert Vogelstein,et al.  Mutations of mitotic checkpoint genes in human cancers , 1998, Nature.

[39]  J. Brady,et al.  Inhibition of p53 Transactivation Function by the Human T-Cell Lymphotropic Virus Type 1 Tax Protein , 1998, Journal of Virology.

[40]  M. Gossen,et al.  Stimulation of Cyclin-Dependent Kinase Activity and G1- to S-Phase Transition in Human Lymphocytes by the Human T-Cell Leukemia/Lymphotropic Virus Type 1 Tax Protein , 1998, Journal of Virology.

[41]  T. Waldmann,et al.  Proliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteins. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[42]  P. Hanawalt,et al.  Expression of Wild-type p53 Is Required for Efficient Global Genomic Nucleotide Excision Repair in UV-irradiated Human Fibroblasts* , 1997, The Journal of Biological Chemistry.

[43]  M. Tomonaga,et al.  Extensive analysis of the retinoblastoma gene in adult T cell leukemia/lymphoma (ATL) , 1997, Leukemia.

[44]  Wei Gu,et al.  Synergistic activation of transcription by CBP and p53 , 1997, Nature.

[45]  D. Livingston,et al.  Binding and modulation of p53 by p300/CBP coactivators , 1997, Nature.

[46]  C. Boshoff,et al.  The cyclin encoded by Kaposi's sarcoma-associated herpesvirus stimulates cdk6 to phosphorylate the retinoblastoma protein and histone H1 , 1997, Journal of virology.

[47]  John Calvin Reed,et al.  Repression of bax gene expression by the HTLV-1 Tax protein: implications for suppression of apoptosis in virally infected cells. , 1997, Virology.

[48]  R. Wood,et al.  Which DNA polymerases are used for DNA-repair in eukaryotes? , 1997, Carcinogenesis.

[49]  K. Jeang,et al.  Human T-cell leukemia virus type 1 Tax releases cell cycle arrest induced by p16INK4a , 1997, Journal of virology.

[50]  V. Robert-Hebmann,et al.  Transrepression of lck gene expression by human T-cell leukemia virus type 1-encoded p40tax , 1997, Journal of virology.

[51]  A. Levine.  p53, the Cellular Gatekeeper for Growth and Division , 1997, Cell.

[52]  G. Morris,et al.  Human T-cell leukemia virus type 1 Tax transactivates the human proliferating cell nuclear antigen promoter , 1997, Journal of virology.

[53]  F. Diella,et al.  p53 functional impairment and high p21waf1/cip1 expression in human T-cell lymphotropic/leukemia virus type I-transformed T cells. , 1996, Blood.

[54]  N. Horikoshi,et al.  Blockage by Adenovirus E4orf6 of Transcriptional Activation by the p53 Tumor Suppressor , 1996, Science.

[55]  G. Kou,et al.  Human Cytomegalovirus Immediate-Early Protein IE2 Tethers a Transcriptional Repression Domain to p53 (*) , 1996, The Journal of Biological Chemistry.

[56]  D. Reisman,et al.  Transcriptional Repression of p53 by Human T-cell Leukemia Virus Type I Tax Protein (*) , 1995, The Journal of Biological Chemistry.

[57]  P. Hanawalt,et al.  Li-Fraumeni syndrome fibroblasts homozygous for p53 mutations are deficient in global DNA repair but exhibit normal transcription-coupled repair and enhanced UV resistance. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[58]  M. Nerenberg,et al.  Constitutive activation of different Jak tyrosine kinases in human T cell leukemia virus type 1 (HTLV-1) tax protein or virus-transformed cells. , 1995, The Journal of clinical investigation.

[59]  W. Leonard,et al.  Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I. , 1995, Science.

[60]  A. Levine,et al.  Human TAFII31 protein is a transcriptional coactivator of the p53 protein. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[61]  M. Tomonaga,et al.  Homozygous deletions of the p15 (MTS2) and p16 (CDKN2/MTS1) genes in adult T-cell leukemia. , 1995, Blood.

[62]  J. Greenblatt,et al.  Direct interaction of the hepatitis B virus HBx protein with p53 leads to inhibition by HBx of p53 response element-directed transactivation , 1995, Journal of virology.

[63]  T. Ley,et al.  Development of leukemia in mice transgenic for the tax gene of human T-cell leukemia virus type I. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[64]  R. Tjian,et al.  p53 transcriptional activation mediated by coactivators TAFII40 and TAFII60. , 1995, Science.

[65]  T. Hunter,et al.  Cyclins and cancer II: Cyclin D and CDK inhibitors come of age , 1994, Cell.

[66]  G. Hannon,et al.  Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair , 1994, Nature.

[67]  G. Hannon,et al.  The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA , 1994, Nature.

[68]  G. Demers,et al.  Elevated wild-type p53 protein levels in human epithelial cell lines immortalized by the human papillomavirus type 16 E7 gene. , 1994, Virology.

[69]  K. Jeang,et al.  Induction of micronuclei by HTLV-I Tax: a cellular assay for function. , 1993, Virology.

[70]  M. Nerenberg,et al.  Ablation of transplanted HTLV-I tax-transformed tumors in mice by antisense inhibition of NF-kappa B. , 1992, Science.

[71]  E. Cesarman,et al.  Structural and functional analysis of oncogenes and tumor suppressor genes in adult T-cell leukemia/lymphoma shows frequent p53 mutations. , 1992, Blood.

[72]  J. Sodroski,et al.  Role of human T-cell leukemia virus type 1 X region proteins in immortalization of primary human lymphocytes in culture , 1992, Journal of virology.

[73]  W. Greene,et al.  Type I human T cell leukemia virus tax protein transforms rat fibroblasts through the cyclic adenosine monophosphate response element binding protein/activating transcription factor pathway. , 1991, The Journal of clinical investigation.

[74]  Andrew W. Murray,et al.  Feedback control of mitosis in budding yeast , 1991, Cell.

[75]  B. Roberts,et al.  S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function , 1991, Cell.

[76]  Y. Yamada,et al.  Cytogenetic studies of human T-cell leukemia virus type I carriers. A family study. , 1990, Cancer genetics and cytogenetics.

[77]  W. Blattner,et al.  Transactivation of interleukin 2 and its receptor induces immune activation in human T-cell lymphotropic virus type I-associated myelopathy: pathogenic implications and a rationale for immunotherapy. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[78]  M. Sporn,et al.  Transactivation of the transforming growth factor beta 1 (TGF-beta 1) gene by human T lymphotropic virus type 1 tax: a potential mechanism for the increased production of TGF-beta 1 in adult T cell leukemia , 1990, The Journal of experimental medicine.

[79]  Samuel H. Wilson,et al.  HTLV-I trans-activator protein, tax, is a trans-repressor of the human beta-polymerase gene. , 1990, Science.

[80]  S. Yamaoka,et al.  Oncogenic transformation by the tax gene of human T-cell leukemia virus type I in vitro. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[81]  S. Schuetze,et al.  A common site for immortalizing proviral integrations in Friend erythroleukemia: molecular cloning and characterization , 1989, Journal of virology.

[82]  T. Sugimura,et al.  Detection of mRNA for the tax1/rex1 gene of human T-cell leukemia virus type I in fresh peripheral blood mononuclear cells of adult T-cell leukemia patients and viral carriers by using the polymerase chain reaction. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[83]  B. Franza,et al.  HTLV-I tax induces cellular proteins that activate the kappa B element in the IL-2 receptor alpha gene. , 1988, Science.

[84]  P. Perry,et al.  The identification of micronucleated chromosomes: a possible assay for aneuploidy. , 1988, Mutagenesis.

[85]  R. Roeder,et al.  Cellular transcription factors and regulation of IL-2 receptor gene expression by HTLV-I tax gene product. , 1988, Science.

[86]  G. Nabel,et al.  HTLV-1 transactivator induces interleukin-2 receptor expression through an NF-κB-like factor , 1988, Nature.

[87]  Y. Niitsu,et al.  Expression of TGF-beta gene in adult T cell leukemia. , 1988, Blood.

[88]  R. K. Reynolds,et al.  A transgenic mouse model for human neurofibromatosis. , 1987, Science.

[89]  R. K. Reynolds,et al.  The tat gene of human T-lymphotropic virus type 1 induces mesenchymal tumors in transgenic mice. , 1987, Science.

[90]  M. Siekevitz,et al.  Activation of interleukin 2 and interleukin 2 receptor (Tac) promoter expression by the trans-activator (tat) gene product of human T-cell leukemia virus, type I. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[91]  S. L. Cross,et al.  Regulation of the human interleukin-2 receptor α chain promoter: Activation of a nonfunctional promoter by the transactivator gene of HTLV-I , 1987, Cell.

[92]  T. Taniguchi,et al.  Evidence for aberrant activation of the interleukin-2 autocrine loop by HTLV-1-encoded p40x and T3/Ti complex triggering , 1987, Cell.

[93]  J. Bishop.  The molecular genetics of cancer. , 1987, Science.

[94]  F. Barin,et al.  ANTIBODIES TO HUMAN T-LYMPHOTROPIC VIRUS TYPE-I IN PATIENTS WITH TROPICAL SPASTIC PARAPARESIS , 1985, The Lancet.

[95]  G. Klein,et al.  Evolution of tumours and the impact of molecular oncology , 1985, Nature.

[96]  R. Gallo,et al.  Human T-cell leukemia virus (HTLV-I) transcripts in fresh and cultured cells of patients with adult T-cell leukemia. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[97]  W. Blattner,et al.  Human T-cell leukemia virus (HTLV-I) antibodies in Africa. , 1984, Science.

[98]  R. Eddy,et al.  Nonspecific integration of the HTLV provirus genome into adult T-cell leukaemia cells , 1984, Nature.

[99]  K. Sikora,et al.  Leukemia , 1984, British Journal of Cancer.

[100]  K. Miyamoto,et al.  Adult T‐cell leukemia. Chromosome analysis of 15 cases , 1983, Cancer.

[101]  R. Gallo,et al.  Human T-cell leukemia-lymphoma virus (HTLV). , 1983, Progress in hematology.

[102]  M. Yoshida,et al.  Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[103]  K. Nagata,et al.  Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[104]  John D. Minna,et al.  Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma , 1980, Proceedings of the National Academy of Sciences.

[105]  J. Brugge,et al.  Identification of a transformation-specific antigen induced by an avian sarcoma virus , 1977, Nature.