A Very Low SEF Neural Amplifier by Utilizing a High Swing Current-Reuse Amplifier

Although current-reuse amplifier has been widely used in biomedical applications because of their low input-referred thermal noise, they don’t have high output swing and their gain is limited. In this article, a rail-to-rail current-reuse amplifier with a 92 dB open-loop gain is introduced while its power and noise increment is just 7%. The proposed structure is a two stage amplifier which doesn’t need further compensation since all nodes are diode connected except for the output node. In order to show the merit of the proposed structure, the NEF, PEF and SEF of the proposed amplifier in a capacitively-coupled neural amplifier structure is compared to the state-of-the-art neural amplifiers. The amplifier is designed and simulated in a commercially available 0.18 µm CMOS technology. The midband gain of the neural amplifier is 40 dB in the bandwidth between 0.6 Hz and 5 kHz. The proposed structure consumes 1.07 µA current from a 1.2 V supply voltage. The NEF, PEF and SEF of proposed structure are 1.68, 3.4, 0.05, respectively. The total area consumption of the neural amplifier is 0.03 mm2 without pads.

[1]  E. Vittoz,et al.  An analytical MOS transistor model valid in all regions of operation and dedicated to low-voltage and low-current applications , 1995 .

[2]  Reid R. Harrison,et al.  A low-power, low-noise CMOS amplifier for neural recording applications , 2002, 2002 IEEE International Symposium on Circuits and Systems. Proceedings (Cat. No.02CH37353).

[3]  Yuanjin Zheng,et al.  A 0.45 V 100-Channel Neural-Recording IC With Sub-µW/Channel Consumption in 0.18 µm CMOS , 2013, IEEE Trans. Biomed. Circuits Syst..

[4]  N. Joel Two Novel Fully Complementary Self-Biased CMOS Differential Amplifiers , 2004 .

[5]  Rahul Sarpeshkar,et al.  An Energy-Efficient Micropower Neural Recording Amplifier , 2007, IEEE Transactions on Biomedical Circuits and Systems.

[6]  T. Seese,et al.  Characterization of tissue morphology, angiogenesis, and temperature in the adaptive response of muscle tissue to chronic heating. , 1998, Laboratory investigation; a journal of technical methods and pathology.

[7]  Nan Sun,et al.  A 1V 0.25uW inverter-stacking amplifier with 1.07 noise efficiency factor , 2017, VLSIC 2017.

[8]  Jordi Parramon,et al.  A Micropower Low-Noise Neural Recording Front-End Circuit for Epileptic Seizure Detection , 2011, IEEE Journal of Solid-State Circuits.

[9]  Shuang Song,et al.  A Low-Voltage Chopper-Stabilized Amplifier for Fetal ECG Monitoring With a 1.41 Power Efficiency Factor , 2015, IEEE Transactions on Biomedical Circuits and Systems.

[10]  B. Venkataramani,et al.  A Power Efficient Low Noise Preamplifier for Biomedical Applications , 2013, J. Low Power Electron..

[11]  Hariprasad Chandrakumar,et al.  A High Dynamic-Range Neural Recording Chopper Amplifier for Simultaneous Neural Recording and Stimulation , 2017, IEEE Journal of Solid-State Circuits.

[12]  W.M.C. Sansen,et al.  A micropower low-noise monolithic instrumentation amplifier for medical purposes , 1987 .

[13]  M. Molinas,et al.  A fully differential capacitively-coupled high CMRR low-power chopper amplifier for EEG dry electrodes , 2020 .