Exfoliation syndrome: assembling the puzzle pieces

To summarize various topics and the cutting edge approaches to refine XFS pathogenesis that were discussed at the 21st annual Glaucoma Foundation Think Tank meeting in New York City, Sept. 19–20, 2014.

[1]  Ping Liu,et al.  LOXL1 Gene Polymorphism With Exfoliation Syndrome/Exfoliation Glaucoma: A Meta-Analysis , 2016, Journal of glaucoma.

[2]  C. Ekström,et al.  Pseudoexfoliation and mortality: a population‐based 30‐year follow‐up study , 2015, Acta ophthalmologica.

[3]  M. Nöthen,et al.  A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome , 2015, Nature Genetics.

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[6]  L. Pasquale,et al.  Prospects for gene-environment interactions in exfoliation syndrome. , 2014, Journal of glaucoma.

[7]  Debananda Padhi,et al.  Role of an extracellular chaperone, Clusterin in the pathogenesis of Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma. , 2014, Experimental eye research.

[8]  U. Schlötzer-Schrehardt,et al.  Expression and regulation of LOXL1 and elastin-related genes in eyes with exfoliation syndrome. , 2014, Journal of glaucoma.

[9]  J. Hejtmancik,et al.  Lysyl oxidase-like 1 gene in the reversal of promoter risk allele in pseudoexfoliation syndrome. , 2014, JAMA ophthalmology.

[10]  W. Willett,et al.  A prospective study of folate, vitamin B₆, and vitamin B₁₂ intake in relation to exfoliation glaucoma or suspected exfoliation glaucoma. , 2014, JAMA ophthalmology.

[11]  L. Pasquale,et al.  Relation between time spent outdoors and exfoliation glaucoma or exfoliation glaucoma suspect. , 2014, American journal of ophthalmology.

[12]  R. Ritch,et al.  Clusterin and complement activation in exfoliation glaucoma. , 2014, Investigative ophthalmology & visual science.

[13]  A. Tarkkanen,et al.  Mortality in Primary Open-Angle Glaucoma and Exfoliative Glaucoma , 2014, European journal of ophthalmology.

[14]  L. Pasquale,et al.  Disruption of the blood-aqueous barrier and lens abnormalities in mice lacking lysyl oxidase-like 1 (LOXL1). , 2014, Investigative ophthalmology & visual science.

[15]  T. Braun,et al.  Patient-specific iPSC-derived photoreceptor precursor cells as a means to investigate retinitis pigmentosa , 2013, eLife.

[16]  T. Gonen,et al.  Renal artery stenosis and abdominal aorta aneurysm in patients with pseudoexfoliation syndrome , 2013, Eye.

[17]  M. Davis,et al.  Structure and function of the mammalian fibrillin gene family: implications for human connective tissue diseases. , 2012, Molecular genetics and metabolism.

[18]  W. Willett,et al.  The Relationship between caffeine and coffee consumption and exfoliation glaucoma or glaucoma suspect: a prospective study in two cohorts. , 2012, Investigative ophthalmology & visual science.

[19]  S. Gartaganis,et al.  Prevalence and severity of sensorineural hearing loss in patients with exfoliation syndrome. , 2012, European review for medical and pharmacological sciences.

[20]  S. Moghimi,et al.  Early-onset Pseudoexfoliation Syndrome following Multiple Intraocular Procedures , 2012, Journal of ophthalmic & vision research.

[21]  Fan Xu,et al.  Plasma homocysteine, serum folic acid, serum vitamin B12, serum vitamin B6, MTHFR and risk of pseudoexfoliation glaucoma: a meta-analysis , 2012, Graefe's Archive for Clinical and Experimental Ophthalmology.

[22]  U. Schlötzer-Schrehardt,et al.  Regulation of lysyl oxidase-like 1 (LOXL1) and elastin-related genes by pathogenic factors associated with pseudoexfoliation syndrome. , 2011, Investigative ophthalmology & visual science.

[23]  N. Demir,et al.  Assessment of myocardial ischaemia using tissue Doppler imaging in pseudoexfoliation syndrome , 2011, Eye.

[24]  Denise S. Kim,et al.  Geographic and climatic factors associated with exfoliation syndrome. , 2011, Archives of ophthalmology.

[25]  J. Haines,et al.  Endothelial nitric oxide synthase gene variants and primary open-angle glaucoma: interactions with hypertension, alcohol intake, and cigarette smoking. , 2011, Archives of ophthalmology.

[26]  J. Haines,et al.  LOXL1 promoter haplotypes are associated with exfoliation syndrome in a U.S. Caucasian population. , 2011, Investigative ophthalmology & visual science.

[27]  A. Ruggeri,et al.  In vivo confocal microscopic evidence of keratopathy in patients with pseudoexfoliation syndrome. , 2011, Investigative ophthalmology & visual science.

[28]  J. Constantinidis,et al.  Hearing Evaluation in Patients with Exfoliative and Primary Open-Angle Glaucoma , 2011, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[29]  Hasan Kaya,et al.  Is pseudoexfoliation syndrome associated with coronary artery disease? , 2010, North American journal of medical sciences.

[30]  S. Gartaganis,et al.  Exfoliation syndrome related to sensorineural hearing loss , 2010, Clinical & experimental ophthalmology.

[31]  M. Ramsay,et al.  Major LOXL1 risk allele is reversed in exfoliation glaucoma in a black South African population , 2010, Molecular vision.

[32]  R. Ritch,et al.  Retinal vascular occlusions occur more frequently in the more affected eye in exfoliation syndrome , 2010, Eye.

[33]  J. Haines,et al.  Endothelial nitric oxide synthase gene variants and primary open-angle glaucoma: interactions with sex and postmenopausal hormone use. , 2010, Investigative ophthalmology & visual science.

[34]  R. Ritch,et al.  Association of exfoliation syndrome and central retinal vein occlusion: an ultrastructural analysis , 2010, Acta ophthalmologica.

[35]  J. Cirulis,et al.  Functional Consequences of Homocysteinylation of the Elastic Fiber Proteins Fibrillin-1 and Tropoelastin* , 2009, The Journal of Biological Chemistry.

[36]  U. Schlötzer-Schrehardt,et al.  Exploring functional candidate genes for genetic association in german patients with pseudoexfoliation syndrome and pseudoexfoliation glaucoma. , 2009, Investigative ophthalmology & visual science.

[37]  A. Crandall,et al.  Late in-the-bag spontaneous intraocular lens dislocation: evaluation of 86 consecutive cases. , 2009, Ophthalmology.

[38]  Michael G. Anderson,et al.  Lyst mutation in mice recapitulates iris defects of human exfoliation syndrome. , 2009, Investigative ophthalmology & visual science.

[39]  W. Hodge,et al.  Biometric characteristics of eyes with exfoliation syndrome and occludable as well as open angles and eyes with primary open-angle glaucoma. , 2009, Canadian journal of ophthalmology. Journal canadien d'ophtalmologie.

[40]  J. Haines,et al.  Lack of association of polymorphisms in homocysteine metabolism genes with pseudoexfoliation syndrome and glaucoma , 2008, Molecular vision.

[41]  M. Orhan,et al.  Systemic Associations and Prevalence of Exfoliation Syndrome in Patients Scheduled for Cataract Surgery , 2008, European journal of ophthalmology.

[42]  M. Kollai,et al.  Decreased Cardiovagal Regulation in Exfoliation Syndrome , 2008, Journal of glaucoma.

[43]  S. Yazdani,et al.  Sensorineural hearing loss in pseudoexfoliation syndrome. , 2007, Ophthalmology.

[44]  A. Konstas,et al.  Evaluation of the Acoustic Function in Pseudoexfoliation Syndrome and Exfoliation Glaucoma: Audiometric and Tympanometric Findings , 2008, European journal of ophthalmology.

[45]  D. Jacobsen,et al.  Molecular targeting of proteins by L-homocysteine: mechanistic implications for vascular disease. , 2007, Antioxidants & redox signaling.

[46]  Kari Stefansson,et al.  Common Sequence Variants in the LOXL1 Gene Confer Susceptibility to Exfoliation Glaucoma , 2007, Science.

[47]  J. Kornhuber,et al.  Homocysteine in Tear Fluid of Patients With Pseudoexfoliation Glaucoma , 2007, Journal of glaucoma.

[48]  M. Turaçli,et al.  Sensorineural hearing loss in pseudoexfoliation. , 2007, Canadian journal of ophthalmology. Journal canadien d'ophtalmologie.

[49]  M. Çıtırık,et al.  A possible link between the pseudoexfoliation syndrome and coronary artery disease , 2007, Eye.

[50]  N. Yüksel,et al.  Homocysteine Levels in Plasma and Sensorineural Hearing Loss in Patients with Pseudoexfoliation Syndrome , 2006, European journal of ophthalmology.

[51]  M. Kollai,et al.  Increase of carotid artery stiffness and decrease of baroreflex sensitivity in exfoliation syndrome and glaucoma , 2006, British Journal of Ophthalmology.

[52]  D. Reinhardt,et al.  Modification of the Structure and Function of Fibrillin-1 by Homocysteine Suggests a Potential Pathogenetic Mechanism in Homocystinuria* , 2005, Journal of Biological Chemistry.

[53]  Reham I. Shaban,et al.  Ocular pseudoexfoliation associated with hearing loss. , 2004, Saudi medical journal.

[54]  J. Kornhuber,et al.  Elevated homocysteine levels in aqueous humor of patients with pseudoexfoliation glaucoma. , 2004, American journal of ophthalmology.

[55]  R. Ritch,et al.  Plasma homocysteine is elevated in patients with exfoliation syndrome. , 2003, American journal of ophthalmology.

[56]  A. Tarkkanen,et al.  Evaluation of the clinical association between exfoliation syndrome and abdominal aortic aneurysm. , 2002, Acta ophthalmologica Scandinavica.

[57]  M. Cahill,et al.  Pseudoexfoliation and sensorineural hearing loss , 2002, Eye.

[58]  A. Tarkkanen,et al.  Exfoliation syndrome as a risk factor for cataract development: Five‐year follow‐up of lens opacities in exfoliation syndrome , 2001, Journal of cataract and refractive surgery.

[59]  C. Fletcher,et al.  Dystonia and cerebellar atrophy in Cacna1a null mice lacking P/Q calcium channel activity , 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[60]  U. Schlötzer-Schrehardt,et al.  Pseudoexfoliation syndrome and aneurysms of the abdominal aorta , 2001, The Lancet.

[61]  U. Schlötzer-Schrehardt,et al.  Energy-filtering transmission electron microscopy (EFTEM) in the elemental analysis of pseudoexfoliative material , 2001, Current eye research.

[62]  D. Hodge,et al.  Cardiovascular and cerebrovascular mortality associated with ocular pseudoexfoliation. , 2000, American journal of ophthalmology.

[63]  R. Rozen,et al.  A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. , 1998, Molecular genetics and metabolism.

[64]  P. Lakatos,et al.  Cold pressor test and plasma endothelin-1 concentration in primary open-angle and capsular glaucoma. , 1998, Journal of glaucoma.

[65]  A. Ringvold,et al.  Pseudo-exfoliation and mortality. , 2009, Acta ophthalmologica Scandinavica.

[66]  P. Ueland,et al.  Functional modeling of vitamin responsiveness in yeast: a common pyridoxine-responsive cystathionine beta-synthase mutation in homocystinuria. , 1997, Human molecular genetics.

[67]  J. J. Wang,et al.  Association of pseudoexfoliation syndrome with increased vascular risk. , 1997, American journal of ophthalmology.

[68]  R. Ritch,et al.  Exfoliation syndrome in a 17-year-old girl. , 1997, Archives of ophthalmology.

[69]  I. Campbell,et al.  Solution Structure of a Pair of Calcium-Binding Epidermal Growth Factor-like Domains: Implications for the Marfan Syndrome and Other Genetic Disorders , 1996, Cell.

[70]  P. Bork,et al.  Identification and mutation analysis of the complete gene for Chediak–Higashi syndrome , 1996, Nature Genetics.

[71]  R. Matthews,et al.  A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase , 1995, Nature Genetics.

[72]  U. Schlötzer-Schrehardt,et al.  A histopathologic study of zonular instability in pseudoexfoliation syndrome. , 1994, American journal of ophthalmology.

[73]  C. Lowder,et al.  Pseudoexfoliation syndrome masquerading as uveitis. , 1994, American journal of ophthalmology.

[74]  R. Ritch.  Exfoliation syndrome-the most common identifiable cause of open-angle glaucoma. , 1994, Journal of glaucoma.

[75]  G. Naumann,et al.  Pseudoexfoliation syndrome. Ocular manifestation of a systemic disorder? , 1992, Archives of ophthalmology.

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