The First One-Pot Synthesis of L-7-Iodotryptophan (IIIe) from 7-Iodoindole and Serine, and an Improved Synthesis of Other L-7-Halotryptophans.

A bacterial cell lysate containing tryptophan synthase is developed to enable a scalable one-pot biotransformation of indoles to the corresponding tryptophans with serine as coupling partner.