Squamous Cell Carcinoma Pathology Section

5 , GoP al nath 6 , anil kuMar Gulati 7 ABSTRACT Introduction: Over-expression of p16 INK4a has been reported in tissues of oral squamous cell carcinoma (SCC) associated with Human Papillomaviruses (HPVs). Immunohistochemical (IHC) detection of p16 INK4a is an easy technique than molecular detection of HPVs, hence we investigated the presence of this protein in the most common pre-malignant and malignant oral lesions i.e. leukoplakia and SCC respectively. Material and Methods: We performed IHC detection of p16 INK4a in sections of paraffin embedded formalin fixed tissues of leukoplakia with or without dysplasia (n= 21) and SCC lesions (n= 69) and correlated with various patterns of p16 INK4a positivity

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