Differential specificities of single mitral cells in rabbit olfactory bulb for a homologous series of fatty acid odor molecules.

1. The molecular specificities of single mitral cells and their locations in the rabbit olfactory bulb were studied using extracellular recordings of single-unit spike discharges and oscillatory local field potentials. A panel of carboxylic acid molecules including a homologous series of fatty acids was used as odor stimuli. 2. Mitral cells showing excitatory responses to fatty acid molecules of different hydrocarbon chain length were localized near each other in a region in the dorsomedial part of the olfactory bulb. 3. Individual mitral cells in the dorsomedial region tended to respond to subsets of fatty acid odor molecules having similar hydrocarbon chain length or structure. Mitral cells responding to subsets of fatty acids of different chain length were distributed with partially shifted overlaps in this region. 4. The results show that stereochemical features of odor molecules are encoded by individual bulbar neurons.

[1]  K. Obata,et al.  Immunohistochemical study of subclasses of olfactory nerve fibers and their projections to the olfactory bulb in the rabbit , 1985, The Journal of comparative neurology.

[2]  G. Wasserburg,et al.  Olfactory Discrimination in the Rabbit Olfactory Glomerulus , 1966, Science.

[3]  R. Axel,et al.  A novel multigene family may encode odorant receptors: A molecular basis for odor recognition , 1991, Cell.

[4]  N. Onoda,et al.  Depth distribution of temporal firing patterns in olfactory bulb related to air-intake cycles. , 1980, Journal of neurophysiology.

[5]  K Kishi,et al.  Distribution of dendrites of mitral, displaced mitral, tufted, and granule cells in the rabbit olfactory bulb , 1983, The Journal of comparative neurology.

[6]  K. Mori.  Membrane and synaptic properties of identified neurons in the olfactory bulb , 1987, Progress in Neurobiology.

[7]  D. Lancet.  Vertebrate olfactory reception. , 1986, Annual review of neuroscience.

[8]  N Buonviso,et al.  Response similarity to odors in olfactory bulb output cells presumed to be connected to the same glomerulus: electrophysiological study using simultaneous single-unit recordings. , 1990, Journal of neurophysiology.

[9]  G. Shepherd,et al.  Theoretical reconstruction of field potentials and dendrodendritic synaptic interactions in olfactory bulb. , 1968, Journal of neurophysiology.

[10]  John S. Kauer,et al.  Contributions of topography and parallel processing to odor coding in the vertebrate olfactory pathway , 1991, Trends in Neurosciences.

[11]  M. Meredith,et al.  Patterned response to odor in mammalian olfactory bulb: the influence of intensity. , 1986, Journal of neurophysiology.

[12]  G. Shepherd.  Synaptic organization of the mammalian olfactory bulb. , 1972, Physiological reviews.

[13]  L. Adrian.  The Journal of Laryngology and Otology THE ACTION OF THE MAMMALIAN OLFACTORY ORGAN* , 2022 .

[14]  D. G. Moulton,et al.  Spatial patterning of response to odors in the peripheral olfactory system. , 1976, Physiological reviews.

[15]  R. H. Cagan,et al.  Biochemical studies of olfaction: isolation, characterization, and odorant binding activity of cilia from rainbow trout olfactory rosettes. , 1980, Proceedings of the National Academy of Sciences of the United States of America.